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Nat Commun ; 14(1): 3835, 2023 06 28.
Artículo en Inglés | MEDLINE | ID: mdl-37380648

RESUMEN

Takotsubo cardiomyopathy is a stress-induced cardiovascular disease with symptoms comparable to those of an acute coronary syndrome but without coronary obstruction. Takotsubo was initially considered spontaneously reversible, but epidemiological studies revealed significant long-term morbidity and mortality, the reason for which is unknown. Here, we show in a female rodent model that a single pharmacological challenge creates a stress-induced cardiomyopathy similar to Takotsubo. The acute response involves changes in blood and tissue biomarkers and in cardiac in vivo imaging acquired with ultrasound, magnetic resonance and positron emission tomography. Longitudinal follow up using in vivo imaging, histochemistry, protein and proteomics analyses evidences a continued metabolic reprogramming of the heart towards metabolic malfunction, eventually leading to irreversible damage in cardiac function and structure. The results combat the supposed reversibility of Takotsubo, point to dysregulation of glucose metabolic pathways as a main cause of long-term cardiac disease and support early therapeutic management of Takotsubo.


Asunto(s)
Modelos Animales de Enfermedad , Corazón , Estrés Psicológico , Cardiomiopatía de Takotsubo , Humanos , Femenino , Animales , Ratas , Cardiomiopatía de Takotsubo/metabolismo , Cardiomiopatía de Takotsubo/patología , Ratas Wistar , Corazón/fisiopatología , Miocitos Cardíacos/metabolismo , Miocitos Cardíacos/patología , Glucosa-6-Fosfato/metabolismo , Glucólisis , Estrés Psicológico/complicaciones
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