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Curr Opin Virol ; 40: 28-36, 2020 02.
Artículo en Inglés | MEDLINE | ID: mdl-32279026

RESUMEN

Conventional influenza vaccines are designed to stimulate neutralizing antibodies against immunodominant but highly variable hemagglutinin antigens. Inherent limitations include suboptimal protection against rapidly changing seasonal influenza viruses and a lack of protection against antigenically novel pandemic influenza. New technologies for developing influenza vaccines that induce more broadly protective and durable immunity are a growing area of research and focus on a variety of approaches, including targeting conserved antigens and stimulating cross-reactive T cell responses. This review highlights a new effort to track the development of universal influenza vaccine technologies. The Universal Influenza Vaccine Technology Landscape is intended to provide stakeholders and funders with a common source of information to monitor research progress and identify opportunities for informed investments and collaboration.


Asunto(s)
Vacunas contra la Influenza/inmunología , Gripe Humana/virología , Orthomyxoviridae/inmunología , Animales , Anticuerpos Antivirales/inmunología , Diseño de Fármacos , Humanos , Vacunas contra la Influenza/administración & dosificación , Vacunas contra la Influenza/genética , Gripe Humana/inmunología , Gripe Humana/prevención & control , Orthomyxoviridae/genética
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