Alarming increase in the registration of degenerative rotator cuff-related lesions a nationwide epidemiological study investigating 244,519 patients.

PURPOSE AND HYPOTHESIS: Shoulder lesions are common and a challenge to diagnose. They often result in significant disability for the patient and are an economic burden to society. From recent studies, an increasing incidence has been reported. The purpose of this study was to investigate and map the incidence of shoulder lesions in Denmark from 1996 to 2013 with focus on sex, age and geographical area. METHODS: The Danish National Patient Registry was searched retrospectively to find the number of shoulder lesions in Denmark during the period 1996-2013. Regional population data were retrieved from the services of Statistics Denmark. Incidence rates were analysed using Poisson regression models, and all analyses were done in R 3.2.2, and p values less than 0.05 were considered statistically significant. RESULTS: During the 18-year period, 244,519 patients with a DM 75 diagnosis were registered. Male-to-female ratio was 51:49, and median age was 51. Most frequent were rotator cuff syndrome with a mean incidence rate of 313.3 (confidence interval 241.8-384.8) per 105 person-years at risk (PYRS). A statistically significant increase in overall incidence rate from 149.4 per 105 PYRS in 1996 to 715.3 per 105 PYRS in 2013 was found (p < 0.01). Incidence was highest for men aged 51-70 (1085.1 per 105 PYRS in 2013). There was no significant difference in incidence between sexes. Rural areas had a 1.4-fold higher mean incidence rate than urban areas. CONCLUSION: The incidence of shoulder lesions rapidly increased mainly due to an increase among people of working age (31-70 years). There were no significant differences in incidence between sexes. Rural areas had a 1.4-fold higher incidence rate than urban areas. As shoulder lesions impose a huge socioeconomic burden on society, not to mention a great distress to the patient, the present findings is highly relevant for political decision-making regarding preventive and health promoting initiatives.

Somatostatin-Immunoreactive Pancreaticoduodenal Neuroendocrine Neoplasms: Twenty-Three Cases Evaluated according to the WHO 2010 Classification.

BACKGROUND/OBJECTIVE: Neuroendocrine neoplasms of the pancreas and duodenum with predominant or exclusive immunoreactivity for somatostatin (pdSOMs) are rare, and knowledge about tumour biology, treatment, survival and prognostic factors is limited. This study aims to describe clinical, pathological and biochemical features as well as treatment and prognosis of pdSOMs. DESIGN: Twenty-three patients with pdSOM (9 duodenal, 12 pancreatic and 2 unknown primary tumours) were identified from our prospective neuroendocrine tumour database, and data according to the study aims were recorded. RESULTS: Among the 9 patients with duodenal SOM, the male/female ratio was 4/5. All males and 1 female had neurofibromatosis type 1. Seven patients had stage 1A/B and 2 had stage 2B disease. The Ki-67 index was 1-5% (median 2%). Plasma somatostatin was elevated in the patients with 2B disease. Of the 14 patients with pancreatic SOM or an unknown primary tumour, the male/female ratio was 2/12. One male had multiple endocrine neoplasia type 1. Five had stage 1A/2B and 9 had stage 4. The Ki-67 index was 1-40% (median 7%). Plasma somatostatin was elevated in 7 patients. Patients reported symptoms related to the somatostatinoma syndrome, but none fulfilled the criteria for a full syndrome. Primary tumour in the pancreas, metastatic disease at diagnosis and higher tumour grade were all associated with significantly poorer survival. CONCLUSION: None of the patients with pdSOM presented with the full somatostatinoma syndrome. Prognostic factors are localisation of the primary tumour, dissemination and tumour grade. A Ki-67 index of 5% may discriminate the course of the disease.