Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits.

Neurodegenerative diseases exert an overwhelming socioeconomic burden all around the globe. They are mainly characterized by modified protein accumulation that might trigger various biological responses, including oxidative stress, inflammation, regulation of signaling pathways, and excitotoxicity. These disorders have been widely studied during the last decade in the hopes of developing symptom-oriented therapeutics. However, no definitive cure has yet been discovered. Tea is one of the world's most popular beverages. The same plant, Camellia Sinensis (L.).O. Kuntze, is used to make green, black, and oolong teas. Green tea has been most thoroughly studied because of its anti-cancer, anti-obesity, antidiabetic, anti-inflammatory, and neuroprotective properties. The beneficial effect of consumption of tea on neurodegenerative disorders has been reported in several human interventional and observational studies. The polyphenolic compounds found in green tea, known as catechins, have been demonstrated to have many therapeutic effects. They can help in preventing and, somehow, treating neurodegenerative diseases. Catechins show anti-inflammatory as well as antioxidant effects via blocking cytokines' excessive production and inflammatory pathways, as well as chelating metal ions and free radical scavenging. They may inhibit tau protein phosphorylation, amyloid beta aggregation, and release of apoptotic proteins. They can also lower alpha-synuclein levels and boost dopamine levels. All these factors have the potential to affect neurodegenerative disorders. This review will examine catechins' neuroprotective effects by highlighting their biological, pharmacological, antioxidant, and metal chelation abilities, with a focus on their ability to activate diverse cellular pathways in the brain. This review also points out the mechanisms of catechins in various neurodegenerative and cognitive diseases, including Alzheimer's, Parkinson's, multiple sclerosis, and cognitive deficit.

Heavy metal contamination in wild avian species inhabiting human-modified habitats.

Health of birds and heavy metal toxicity are growing concerns in Pakistan because of irresponsible industrial waste management and farming practices. Eight species of common wild birds were studied from three different study sites which varied in the type of environmental pollution (Kasur: industrial waste, Lahore city: traffic pollution and Shahdara: mixed pollution of traffic, sewerage, and industry which the Ravi River accumulates). Heavy metal analysis of six heavy metals in the various organs of birds showed that there was no evidence of organ preference for metal accumulation in birds. Shahdara and Kasur with numerous industries both showed chromium concentrations above toxicity levels in 54.16% tissues of Granivorous birds, 60% of omnivorous birds, and 33.33% in tissues of carnivorous species. Statistical analysis proved that there is no correlation between weight of birds and accumulation of metals; it depends on food preference of birds and properties of the metals as bioaccumulators or biomagnifiers.