Controlled nanocrystallization of gold nanoclusters within surfactant envelopes: enhancing aggregation-induced emission in solution.

The nanocrystallization of functional molecules has been a subject of recent interest in the current development of nanotechnology. Herein, we report the unprecedented synthesis of single nanocrystals of a molecular gold nanocluster in a homogeneous solution by using surfactant-based nano-envelopes. The co-assembling of a Au8 nanocluster carrying lipophilic phosphine ligands with sodium dodecyl sulfate (SDS) in an aqueous solution results in the formation of sphere-shaped amorphous nano-aggregates coated with the surfactant. Upon sonication, the spherical amorphous aggregates are smoothly shape-shifted into discrete rhombic nanocrystals, which can be tracked by TEM and solution XRD. The transformation into single nanocrystals occurs exclusively without further growth or agglomeration, implying that the crystal growth is restricted within the surfactant nano-envelopes. The robust but flexible nature of the wrapped surfactant is likely responsible for the controlled crystallization. We also demonstrate that the amorphous-to-nanocrystalline transition in solution remarkably enhances the photoluminescence emission from the nanocluster, providing a clear example of crystallization-induced emission enhancement. Notably, the obtained nanocrystals showed high stability in solution and retained their shape, size, and PL intensity even after several months, owing to the densely packed surfactant shell. The present surfactant-directed nanocrystallization method may be applicable to other molecular species to contribute to the development of nanocluster science as well as the designed synthesis of nanomaterials.

Isolation, structural determination, and antiviral activities of a novel alanine-conjugated polyketide from Talaromyces sp.

Antiviral agents are highly sought after. In this study, a novel alkylated decalin-type polyketide, alaspelunin, was isolated from the culture broth of the fungus Talaromyces speluncarum FMR 16671, and its structure was determined using spectroscopic analyses (1D/2D NMR and MS). The compound was condensed with alanine, and its absolute configuration was determined using Marfey's method. Furthermore, the antiviral activity of alaspelunin against various viruses was evaluated, and it was found to be effective against both severe acute respiratory syndrome coronavirus 2 and pseudorabies (Aujeszky's disease) virus, a pathogen affecting pigs. Our results suggest that this compound is a potential broad-spectrum antiviral agent.