Predicting lung cancer survival prognosis based on the conditional survival bayesian network.

Lung cancer is a leading cause of cancer deaths and imposes an enormous economic burden on patients. It is important to develop an accurate risk assessment model to determine the appropriate treatment for patients after an initial lung cancer diagnosis. The Cox proportional hazards model is mainly employed in survival analysis. However, real-world medical data are usually incomplete, posing a great challenge to the application of this model. Commonly used imputation methods cannot achieve sufficient accuracy when data are missing, so we investigated novel methods for the development of clinical prediction models. In this article, we present a novel model for survival prediction in missing scenarios. We collected data from 5,240 patients diagnosed with lung cancer at the Weihai Municipal Hospital, China. Then, we applied a joint model that combined a BN and a Cox model to predict mortality risk in individual patients with lung cancer. The established prognostic model achieved good predictive performance in discrimination and calibration. We showed that combining the BN with the Cox proportional hazards model is highly beneficial and provides a more efficient tool for risk prediction.

Heterogeneous context interaction network for vehicle re-identification.

Capturing global and subtle discriminative information using attention mechanisms is essential to address the challenge of inter-class high similarity for vehicle re-identification (Re-ID) task. Mixing self-information of nodes or modeling context based on pairwise dependencies between nodes are the core ideas of current advanced attention mechanisms. This paper aims to explore how to utilize both dependency context and self-context in an efficient way to facilitate attention to learn more effectively. We propose a heterogeneous context interaction (HCI) attention mechanism that infers the weights of nodes from the interactions of global dependency contexts and local self-contexts to enhance the effect of attention learning. To reduce computational complexity, global dependency contexts are modeled by aggregating number-compressed pairwise dependencies, and the interactions of heterogeneous contexts are restricted to a certain range. Based on this mechanism, we propose a heterogeneous context interaction network (HCI-Net), which uses channel heterogeneous context interaction module (CHCI) and spatial heterogeneous context interaction module (SHCI), and introduces a rigid partitioning strategy to extract important global and fine-grained features. In addition, we design a non-similarity constraint (NSC) that forces the HCI-Net to learn diverse subtle discriminative information. The experiment results on two large datasets, VeRi-776 and VehicleID, show that our proposed HCI-Net achieves the state-of-the-art performance. In particular, the mean average precision (mAP) reaches 83.8% on VeRi-776 dataset.

Reformulating Graph Kernels for Self-Supervised Space-Time Correspondence Learning.

Self-supervised space-time correspondence learning utilizing unlabeled videos holds great potential in computer vision. Most existing methods rely on contrastive learning with mining negative samples or adapting reconstruction from the image domain, which requires dense affinity across multiple frames or optical flow constraints. Moreover, video correspondence prediction models need to uncover more inherent properties of the video, such as structural information. In this work, we propose HiGraph+, a sophisticated space-time correspondence framework based on learnable graph kernels. By treating videos as a spatial-temporal graph, the learning objective of HiGraph+ is issued in a self-supervised manner, predicting the unobserved hidden graph via graph kernel methods. First, we learn the structural consistency of sub-graphs in graph-level correspondence learning. Furthermore, we introduce a spatio-temporal hidden graph loss through contrastive learning that facilitates learning temporal coherence across frames of sub-graphs and spatial diversity within the same frame. Therefore, we can predict long-term correspondences and drive the hidden graph to acquire distinct local structural representations. Then, we learn a refined representation across frames on the node-level via a dense graph kernel. The structural and temporal consistency of the graph forms the self-supervision of model training. HiGraph+ achieves excellent performance and demonstrates robustness in benchmark tests involving object, semantic part, keypoint, and instance labeling propagation tasks. Our algorithm implementations have been made publicly available at https://github.com/zyqin19/HiGraph.

Biomarkers-Aware Asymmetric Bibranch GAN with Adaptive Memory Batch Normalization for Prediction of Anti-VEGF Treatment Response in Neovascular Age-related Macular Degeneration.

The emergence of anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized neovascular age-related macular degeneration (nAMD). Post-therapeutic optical coherence tomography (OCT) imaging facilitates the prediction of therapeutic response to anti-VEGF therapy for nAMD. Although the generative adversarial network (GAN) is a popular generative model for post-therapeutic OCT image generation, it is realistically challenging to gather sufficient pre- and post-therapeutic OCT image pairs, resulting in overfitting. Moreover, the available GAN-based methods ignore local details, such as the biomarkers that are essential for nAMD treatment. To address these issues, a Biomarkers-aware Asymmetric Bibranch GAN (BAABGAN) is proposed to efficiently generate post-therapeutic OCT images. Specifically, one branch is developed to learn prior knowledge with a high degree of transferability from large-scale data, termed the source branch. Then, the source branch transfer knowledge to another branch, which is trained on small-scale paired data, termed the target branch. To boost the transferability, a novel Adaptive Memory Batch Normalization (AMBN) is introduced in the source branch, which learns more effective global knowledge that is impervious to noise via memory mechanism. Also, a novel Adaptive Biomarkers-aware Attention (ABA) module is proposed to encode biomarkers information into latent features of target branches to learn finer local details of biomarkers. The proposed method outperforms traditional GAN models and can produce high-quality post-treatment OCT pictures with limited data sets, as shown by the results of experiments.

Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method.

The outbreak of coronavirus disease 2019 (COVID-19) has severely harmed human society and health. Because there is currently no specific drug for the treatment and prevention of COVID-19, we used a collaborative filtering algorithm to predict which traditional Chinese medicines (TCMs) would be effective in combination for the prevention and treatment of COVID-19. First, we performed drug screening based on the receptor structure prediction method, molecular docking using q-vina to measure the binding ability of TCMs, TCM formulas, and neo-coronavirus proteins, and then performed synergistic filtering based on Laplace matrix calculations to predict potentially effective TCM formulas. Combining the results of molecular docking and synergistic filtering, the new recommended formulas were analyzed by reviewing data platforms or tools such as PubMed, Herbnet, the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, the Guide to the Dispensing of Medicines for Clinical Evidence, and the Dictionary of Chinese Medicine Formulas, as well as medical experts' treatment consensus in terms of herbal efficacy, modern pharmacological studies, and clinical identification and typing of COVID-19 pneumonia, to determine the recommended solutions. We found that the therapeutic effect of a combination of six TCM formulas on the COVID-19 virus is the result of the overall effect of the formula rather than that of specific components of the formula. Based on this, we recommend a formula similar to that of Jinhua Qinggan Granules for the treatment of COVID-19 pneumonia. This study may provide new ideas and new methods for future clinical research. Classification: Biological Science.

Supervised Adaptive Similarity Matrix Hashing.

Compact hash codes can facilitate large-scale multimedia retrieval, significantly reducing storage and computation. Most hashing methods learn hash functions based on the data similarity matrix, which is predefined by supervised labels or a distance metric type. However, this predefined similarity matrix cannot accurately reflect the real similarity relationship among images, which results in poor retrieval performance of hashing methods, especially in multi-label datasets and zero-shot datasets that are highly dependent on similarity relationships. Toward this end, this study proposes a new supervised hashing method called supervised adaptive similarity matrix hashing (SASH) via feature-label space consistency. SASH not only learns the similarity matrix adaptively, but also extracts the label correlations by maintaining consistency between the feature and the label space. This correlation information is then used to optimize the similarity matrix. The experiments on three large normal benchmark datasets (including two multi-label datasets) and three large zero-shot benchmark datasets show that SASH has an excellent performance compared with several state-of-the-art techniques.

Learning Binary Semantic Embedding forLarge-Scale Breast Histology Image Analysis.

With the progress of clinical imaging innovation and machine learning, the computer-assisted diagnosis of breast histology images has attracted broad attention. Nonetheless, the use of computer-assisted diagnoses has been blocked due to the incomprehensibility of customary classification models. In view of this question, we propose a novel method for Learning Binary Semantic Embedding (LBSE). In this study, bit balance and uncorrela-tion constraints, double supervision, discrete optimization and asymmetric pairwise similarity are seamlessly integrated for learning binary semantic-preserving embedding. Moreover, a fusion-based strategy is carefully designed to handle the intractable problem of parameter setting, saving huge amounts of time for boundary tuning. Based on the above-mentioned proficient and effective embedding, classification and retrieval are simultaneously performed to give interpretable image-based deduction and model helped conclusions for breast histology images. Extensive experiments are conducted on three benchmark datasets to approve the predominance of LBSE in different situations.

Feature enhancement network for CNV typing in optical coherence tomography images.

Objective. Choroidal neovascularization (CNV) is a characteristic feature of wet age-related macular degeneration, which is one of the main causes of blindness in the elderly. Automatic classification of CNV in optical coherence tomography images plays an auxiliary role in the clinical treatment of CNV.Approach. This study proposes a feature enhancement network (FE-net) to discriminate between different CNV types with high inter-class similarity. The FE-net consists of two branches: discriminative FE and diverse FE. In the discriminative FE branch, a novel class-specific feature extraction module is introduced to learn class-specific features, and the discriminative loss is introduced to make the learned features more discriminative. In the diverse FE branch, the attention region selection is used to mine the multi-attention features from feature maps in the same class, and the diverse loss is introduced to guarantee that the attention features are different, which can improve the diversity of the learned features.Main results. Experiments were conducted on our CNV dataset, with significant accuracy of 92.33%, 87.45%, 90.10%, and 91.25% on ACC, AUC, SEN, and SPE, respectively.Significance. These results demonstrate that the proposed method can effectively learn the discriminative and diverse features to discriminate subtle differences between different types of CNV. And accurate classification of CNV plays an auxiliary role in clinical treatmen.

Multi-modality relation attention network for breast tumor classification.

Automatic breast image classification plays an important role in breast cancer diagnosis, and multi-modality image fusion may improve classification performance. However, existing fusion methods ignore relevant multi-modality information in favor of improving the discriminative ability of single-modality features. To improve classification performance, this paper proposes a multi-modality relation attention network with consistent regularization for breast tumor classification using diffusion-weighted imaging (DWI) and apparent dispersion coefficient (ADC) images. Within the proposed network, a novel multi-modality relation attention module improves the discriminative ability of single-modality features by exploring the correlation information between two modalities. In addition, a module ensures the classification consistency of ADC and DWI modality, thus improving robustness to noise. Experimental results on our database demonstrate that the proposed method is effective for breast tumor classification, and outperforms existing multi-modality fusion methods. The AUC, accuracy, specificity, and sensitivity are 85.1%, 86.7%, 83.3%, and 88.9% respectively.

Discrete Two-Step Cross-Modal Hashing through the Exploitation of Pairwise Relations.

The cross-modal hashing method can map heterogeneous multimodal data into a compact binary code that preserves semantic similarity, which can significantly enhance the convenience of cross-modal retrieval. However, the currently available supervised cross-modal hashing methods generally only factorize the label matrix and do not fully exploit the supervised information. Furthermore, these methods often only use one-directional mapping, which results in an unstable hash learning process. To address these problems, we propose a new supervised cross-modal hash learning method called Discrete Two-step Cross-modal Hashing (DTCH) through the exploitation of pairwise relations. Specifically, this method fully exploits the pairwise similarity relations contained in the supervision information: for the label matrix, the hash learning process is stabilized by combining matrix factorization and label regression; for the pairwise similarity matrix, a semirelaxed and semidiscrete strategy is adopted to potentially reduce the cumulative quantization errors while improving the retrieval efficiency and accuracy. The approach further combines an exploration of fine-grained features in the objective function with a novel out-of-sample extension strategy to enable the implicit preservation of consistency between the different modal distributions of samples and the pairwise similarity relations. The superiority of our method was verified through extensive experiments using two widely used datasets.

Weighted-Attribute Triplet Hashing for Large-Scale Similar Judicial Case Matching.

Similar judicial case matching aims to enable an accurate selection of a judicial document that is most similar to the target document from multiple candidates. The core of similar judicial case matching is to calculate the similarity between two fact case documents. Owing to similar judicial case matching techniques, legal professionals can promptly find and judge similar cases in a candidate set. These techniques can also benefit the development of judicial systems. However, the document of judicial cases not only is long in length but also has a certain degree of structural complexity. Meanwhile, a variety of judicial cases are also increasing rapidly; thus, it is difficult to find the document most similar to the target document in a large corpus. In this study, we present a novel similar judicial case matching model, which obtains the weight of judicial feature attributes based on hash learning and realizes fast similar matching by using a binary code. The proposed model extracts the judicial feature attributes vector using the bidirectional encoder representations from transformers (BERT) model and subsequently obtains the weighted judicial feature attributes through learning the hash function. We further impose triplet constraints to ensure that the similarity of judicial case data is well preserved when projected into the Hamming space. Comprehensive experimental results on public datasets show that the proposed method is superior in the task of similar judicial case matching and is suitable for large-scale similar judicial case matching.

Robust Structured Graph Clustering.

Graph-based clustering methods have achieved remarkable performance by partitioning the data samples into disjoint groups with the similarity graph that characterizes the sample relations. Nevertheless, their learning scheme still suffers from two important problems: 1) the similarity graph directly constructed from the raw features may be unreliable as real-world data always involves adverse noises, outliers, and irrelevant information and 2) most graph-based clustering methods adopt two-step learning strategy that separates the similarity graph construction and clustering into two independent processes. Under such circumstance, the generated graph is unstructured and fixed. It may suffer from a low-quality clustering structure and thus lead to suboptimal clustering performance. To alleviate these limitations, in this article we propose a robust structured graph clustering (RSGC) model. We formulate a novel learning framework to simultaneously learn a robust structured similarity graph and perform clustering. Specifically, the structured graph with proper probabilistic neighborhood assignment is adaptively learned on a robust latent representation that resists the noises and outliers. Furthermore, an explicit rank constraint is imposed on the Laplacian matrix to structurize the graph such that the number of the connected components is exactly equal to the ground-truth cluster number. To solve the challenging objective formulation, we propose to first transform it into an equivalent one that can be tackled more easily. An iterative solution based on the augmented Lagrangian multiplier is then derived to solve the model. In RSGC, the discrete cluster labels can be directly obtained by partitioning the learned similarity graph without reliance on label discretization strategy as most graph-based clustering methods. Experiments on both synthetic and real data sets demonstrate the superiority of the proposed method compared with the state-of-the-art clustering techniques.

Model Optimization Boosting Framework for Linear Model Hash Learning.

Efficient hashing techniques have attracted extensive research interests in both storage and retrieval of highdimensional data, such as images and videos. In existing hashing methods, a linear model is commonly utilized owing to its efficiency. To obtain better accuracy, linear-based hashing methods focus on designing a generalized linear objective function with different constraints or penalty terms that consider the inherent characteristics and neighborhood information of samples. Differing from existing hashing methods, in this study, we propose a self-improvement framework called Model Boost (MoBoost) to improve model parameter optimization for linear-based hashing methods without adding new constraints or penalty terms. In the proposed MoBoost, for a linear-based hashing method, we first repeatedly execute the hashing method to obtain several hash codes to training samples. Then, utilizing two novel fusion strategies, these codes are fused into a single set. We also propose two new criteria to evaluate the goodness of hash bits during the fusion process. Based on the fused set of hash codes, we learn new parameters for the linear hash function that can significantly improve the accuracy. In general, the proposed MoBoost can be adopted by existing linear-based hashing methods, achieving more precise and stable performance compared to the original methods, and adopting the proposed MoBoost will incur negligible time and space costs. To evaluate the proposed MoBoost, we performed extensive experiments on four benchmark datasets, and the results demonstrate superior performance.

IA-net: informative attention convolutional neural network for choroidal neovascularization segmentation in OCT images.

Choroidal neovascularization (CNV) is a characteristic feature of wet age-related macular degeneration (AMD). Quantification of CNV is useful to clinicians in the diagnosis and treatment of CNV disease. Before quantification, CNV lesion should be delineated by automatic CNV segmentation technology. Recently, deep learning methods have achieved significant success for medical image segmentation. However, some CNVs are small objects which are hard to discriminate, resulting in performance degradation. In addition, it's difficult to train an effective network for accurate segmentation due to the complicated characteristics of CNV in OCT images. In order to tackle these two challenges, this paper proposed a novel Informative Attention Convolutional Neural Network (IA-net) for automatic CNV segmentation in OCT images. Considering that the attention mechanism has the ability to enhance the discriminative power of the interesting regions in the feature maps, the attention enhancement block is developed by introducing the additional attention constraint. It has the ability to force the model to pay high attention on CNV in the learned feature maps, improving the discriminative ability of the learned CNV features, which is useful to improve the segmentation performance on small CNV. For accurate pixel classification, the novel informative loss is proposed with the incorporation of an informative attention map. It can focus training on a set of informative samples that are difficult to be predicted. Therefore, the trained model has the ability to learn enough information to classify these informative samples, further improving the performance. The experimental results on our database demonstrate that the proposed method outperforms traditional CNV segmentation methods.