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1.
J Am Coll Cardiol ; 29(5): 1095-101, 1997 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-9120165

RESUMEN

OBJECTIVES: The purposes of this study were to determine the growth pattern of the pulmonary valve (PV) annulus and right heart structures in patients with critical and severe pulmonary stenosis (PS) after balloon dilation, and to determine any morphometric or hemodynamic differences between cyanotic infants with critical PS and asymptomatic infants with severe PS that may account for their varied clinical presentations. BACKGROUND: Growth of the PV annulus and right heart structures in patients with critical PS after balloon valvuloplasty has not clearly been defined. In addition, the anatomic and hemodynamic factors that determine whether an infant with severe PS will present with cyanosis or without symptoms are not well understood. METHODS: Measurements of the PV annulus, tricuspid valve (TV) annulus and main, right and left pulmonary arteries were obtained from initial and follow-up echocardiograms, and Z values were calculated. Hemodynamic data and balloon pulmonary valvuloplasty techniques were reviewed. Right ventricular (RV) volumes were measured from angiograms. RESULTS: Fourteen patients with critical PS (mean [+/- SD] age 0.21 +/- 0.37 months) and 20 patients with severe PS (mean age 2.6 +/- 2.9 months) were evaluated at presentation and at 32 +/- 33 and 42 +/- 32 months of follow-up, respectively. Balloon pulmonary valvuloplasty was successful in 64% of patients with critical PS and in 90% of patients with severe PS. The PV, TV and pulmonary arteries increased in size after balloon pulmonary valvuloplasty in both groups at a rate that paralleled or exceeded the rate of somatic growth. The initial TV diameter and RV volume were smaller in patients with critical PS than in those with severe PS (p < 0.05 and p < 0.0008, respectively). CONCLUSIONS: After balloon pulmonary valvuloplasty in infants with critical and severe PS, right heart structures increase in size at a rate that parallels or exceeds the rate of somatic growth. The primary morphometric differences between these groups are a smaller TV diameter and RV volume in infants with critical PS. This may contribute to increased right to left atrial shunting and account for the variations in clinical presentation.


Asunto(s)
Estenosis de la Válvula Pulmonar/diagnóstico por imagen , Válvula Pulmonar/diagnóstico por imagen , Cateterismo , Hemodinámica , Humanos , Lactante , Válvula Pulmonar/crecimiento & desarrollo , Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/fisiopatología , Estenosis de la Válvula Pulmonar/terapia , Estudios Retrospectivos , Resultado del Tratamiento , Ultrasonografía
2.
J Am Coll Cardiol ; 25(3): 730-4, 1995 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-7860921

RESUMEN

UNLABELLED: OBJECTIVES, This retrospective analysis was designed to examine the intermediate and long-term effects of balloon angioplasty for native coarctation of the aorta and to determine whether any factors are predictive of outcome. BACKGROUND: Balloon angioplasty for native coarctation of the aorta is controversial. Concerns exist over lack of long-term follow-up and possible formation of aneurysms. The role of transverse arch and isthmus hypoplasia after balloon dilation is unknown. METHODS: Included in the study were all patients 3 days to 29 years old (mean age 4.6 years) referred for possible balloon dilation to the pediatric cardiac catheterization laboratory with evidence of a discrete coarctation of the aorta. The hemodynamic data, angiograms and clinical records of 102 patients were examined, with follow-up data from 2 to 117 months (median 36.2) available in 92 patients. RESULTS: Immediate success with balloon angioplasty was achieved in 93 (91.2%) of the 102 patients. Seventy-one patients (77.2%) with intermediate follow-up data (range 12 to 117 months) available are asymptomatic and normotensive, with insignificant arm to leg blood pressure gradients (< or = 20 mm Hg). Twenty-one patients (22.8%) with an initial successful result developed an increase in gradient 2 at 86 months after angioplasty, requiring reintervention in 18. Follow-up > 72 months is available in 17 patients, 16 of whom are normotensive and have not required additional intervention. No additional intervention was needed in 88.4% of older children and infants > 7 months old. Ten of the 13 surviving neonates who initially had a successful dilation required reangioplasty or operation 14 days to 10 months (median 4.6 months) after angioplasty. Transverse arch hypoplasia had minimal effect on follow-up blood pressure gradient, whereas isthmic hypoplasia was associated with reintervention in 50%. A small aneurysm was noted in 2 (1.9%) of 102 patients. CONCLUSIONS: Balloon angioplasty of native aortic coarctation is effective in infants and older children. In neonates, balloon angioplasty provides effective palliation only. Aneurysm formation is rare; however, lifetime follow-up is warranted.


Asunto(s)
Angioplastia Coronaria con Balón , Coartación Aórtica/terapia , Adolescente , Adulto , Angioplastia Coronaria con Balón/efectos adversos , Niño , Preescolar , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Pronóstico , Estudios Retrospectivos , Resultado del Tratamiento
3.
J Am Coll Cardiol ; 2(3): 531-7, 1983 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-6875116

RESUMEN

The results of two-dimensional echocardiography and biplane angiocardiography from 47 infants with congenital atrioventricular (AV) valve abnormalities were compared. Eleven patients had atresia of the right AV valve, 10 had atresia of the left AV valve, 4 had hypoplasia of the right AV valve and 5 had hypoplasia of the left AV valve. Twelve patients had endocardial cushion defect, three had single ventricle and two had straddling of the left AV valve. There was agreement between the two techniques as to the number of AV valves present in each patient. The echocardiographic estimate of valve anular diameter was below normal in seven of the eight patients thought to have a hypoplastic anulus by angiocardiography. In 10 of the 12 patients with endocardial cushion defect, there was agreement between the two techniques as to the presence or absence of atrial and ventricular septal defect. The chordal attachments of straddling valves were better visualized by echocardiography; flow patterns and effective orifice size were better demonstrated by angiocardiography. The subcostal four chamber echocardiographic views and cranially angulated oblique angiocardiographic views were comparable and provided the best images for determination of the size and number of AV valves and their relation to the atrial and ventricular septa.


Asunto(s)
Angiocardiografía , Ecocardiografía , Válvula Mitral/anomalías , Válvula Tricúspide/anomalías , Defectos de la Almohadilla Endocárdica/diagnóstico , Cardiopatías Congénitas/diagnóstico , Humanos , Lactante
4.
J Am Coll Cardiol ; 5(3): 757-60, 1985 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-3973274

RESUMEN

Aortico-left ventricular tunnel is a rare congenital anomaly that presents as aortic regurgitation and congestive heart failure in childhood. Its association with a ventricular septal defect is even more rare. Because of the distortion of the normal anatomy around the aortic valve and the rarity of this combination of defects, the diagnosis of aortico-left ventricular tunnel with ventricular septal defect may be difficult. The two-dimensional and Doppler echocardiographic findings of aortico-left ventricular tunnel are described.


Asunto(s)
Aorta/anomalías , Ecocardiografía , Cardiopatías Congénitas/diagnóstico , Defectos del Tabique Interventricular/diagnóstico , Angiocardiografía , Aorta/fisiopatología , Diagnóstico Diferencial , Cardiopatías Congénitas/diagnóstico por imagen , Cardiopatías Congénitas/fisiopatología , Defectos del Tabique Interventricular/diagnóstico por imagen , Defectos del Tabique Interventricular/fisiopatología , Ventrículos Cardíacos/anomalías , Ventrículos Cardíacos/diagnóstico por imagen , Ventrículos Cardíacos/fisiopatología , Humanos , Lactante , Masculino
5.
J Am Coll Cardiol ; 38(2): 521-6, 2001 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-11499747

RESUMEN

OBJECTIVES: We sought to determine the incidence of and risk factors for the development of restenosis and neointimal proliferation after endovascular stent implantation for congenital heart disease (CHD). BACKGROUND: Risk factors for the development of restenosis and neointimal proliferation are poorly understood. METHODS: This was a retrospective review of patients who underwent endovascular stent redilation between September 1989 and February 2000. RESULTS: Of 368 patients who had 752 stents implanted, 220 were recatheterized. Of those 220 patients, 103 underwent stent redilation. Patients were classified into three groups: 1) those with pulmonary artery stenosis (n = 94), tetralogy of Fallot/pulmonary atresia (n = 72), congenital branch pulmonary stenosis (n = 9), status post-Fontan operation (n = 6), status post-arterial switch operation (n = 7); 2) those with iliofemoral venous obstruction (n = 6); and 3) those with miscellaneous disorders (n = 3). The patients' median age was 9.9 years (range 0.5 to 39.8); their mean follow-up duration was 3.8 years (range 0.1 to 10). Indications for stent redilation included somatic growth (n = 67), serial dilation (n = 27) and development of neointimal proliferation or restenosis, or both (n = 9). There was a low incidence of neointimal proliferation (1.8%) and restenosis (2%). There were no deaths. Complications included pulmonary edema (n = 1), hemoptysis (n = 1) and contralateral stent compression (n = 2). CONCLUSIONS: Redilation or further dilation of endovascular stents for CHD is effective as late as 10 years. The risk of neointimal proliferation (1.8%) and restenosis (2%) is low and possibly avoidable. Awareness of specific risk factors and modification of the stent implantation technique, including avoidance of minimal stent overlap and sharp angulation of the stent to the vessel wall and avoidance of overdilation, have helped to reduce the incidence of restenosis.


Asunto(s)
Angioplastia de Balón , Arteriopatías Oclusivas/etiología , Oclusión de Injerto Vascular/etiología , Cardiopatías Congénitas/cirugía , Stents/efectos adversos , Adolescente , Adulto , Arteriopatías Oclusivas/diagnóstico por imagen , Arteriopatías Oclusivas/terapia , División Celular , Niño , Preescolar , Femenino , Estudios de Seguimiento , Oclusión de Injerto Vascular/diagnóstico por imagen , Oclusión de Injerto Vascular/terapia , Cardiopatías Congénitas/complicaciones , Humanos , Lactante , Masculino , Arteria Pulmonar/diagnóstico por imagen , Arteria Pulmonar/patología , Radiografía , Estudios Retrospectivos , Factores de Riesgo
6.
J Am Coll Cardiol ; 37(1): 251-7, 2001 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11153747

RESUMEN

OBJECTIVES: The study evaluated the safety and efficacy of stent reconstruction of stenotic/occluded iliofemoral veins (IFV) and inferior vena cava (IVC). BACKGROUND: Patients with congenital heart defects and stenotic or occluded IFV/IVC may encounter femoral venous access problems during future cardiac surgeries or catheterizations. METHODS: Twenty-four patients (median age 4.9 years) underwent implantation of 85 stents in 22 IFV and 6 IVC. Fifteen vessels were severely stenotic and 13 were completely occluded. Although guide wires were easily passed across the stenotic vessels, occluded vessels required puncture through the thrombosed sites using a stiff wire or transseptal needle. Once traversed, the occluded site was dilated serially prior to stent implantation. RESULTS: Following stent placement, the mean vessel diameter increased from 0.9 +/- 1.6 to 7.4 +/- 2.6 mm (p < 0.05). Twenty-one of 28 vessels had long segment stenosis/occlusion requiring two to seven overlapping stents. Repeat catheterizations were performed in seven patients (9 stented vessels) at mean follow-up of 1.6 years. Seven vessels remained patent with mean diameter of 6.4 +/- 2.0 mm. Two vessels were occluded, but they were easily recanalized and redilated. Echocardiographic follow-up in two patients with IVC stents demonstrated wide patency. In four additional patients, a stented vessel was utilized for vascular access during subsequent cardiac surgery (n = 3) and endomyocardial biopsy (n = 1). Therefore, 13 of 15 stented vessels (87%) remained patent at follow-up thus far. CONCLUSIONS: Stenotic/obstructed IFV and IVC may be reconstructed using stents to re-establish venous access to the heart for future cardiac catheterization and/or surgeries.


Asunto(s)
Angioplastia de Balón , Cateterismo Cardíaco , Vena Femoral , Vena Ilíaca , Stents , Vena Cava Inferior , Preescolar , Constricción Patológica/terapia , Femenino , Cardiopatías Congénitas/diagnóstico , Cardiopatías Congénitas/terapia , Humanos , Masculino , Resultado del Tratamiento
7.
J Am Coll Cardiol ; 31(3): 661-7, 1998 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-9502650

RESUMEN

OBJECTIVES: This report describes the results of the Food and Drug Administration's phase 1 and 2 clinical trials of intravascular stents at Texas Children's Hospital. BACKGROUND: Since the late 1980s, intravascular stent implantation for the treatment of arterial and venous stenoses in congenital heart disease has been highly successful. METHODS: Stents were placed in postoperative pulmonary artery (PA) stenoses, congenital PA stenoses or stenoses of systemic veins/venous anastomoses. Prospective collection of data according to protocol was done before intervention, after stent implantation and at follow-up catheterization. RESULTS: At stent implantation, pressure gradients decreased significantly in all three groups (mean +/- SD): from 46 +/- 25 to 10 +/- 13 mm Hg in postoperative PA stenoses (p < 0.001); from 71 +/- 45 to 15 +/- 21 mm Hg in congenital PA stenoses (p < 0.001); and from 7 +/- 6 to 1 +/- 2 mm Hg in stenoses of systemic veins/venous anastomoses stenoses (p < 0.001). Vessel diameters markedly increased: from 6 +/- 3 to 12 +/- 3 mm in postoperative PA stenoses (p < 0.001); from 3 + 1 to 9 + 1 mm in congenital PA stenoses (p < 0.001); and from 3 +/- 4 to 12 +/- 4 mm in stenoses of systemic veins/venous anastomoses (p < 0.001). In the postoperative and congenital PA stenoses groups, right ventricular pressure decreased (right ventricular pressure indexed to femoral artery pressure ratio): from 0.63 +/- 0.2 to 0.41 +/- 0.02 (p < 0.001) and from 0.71 +/- 0.3 to 0.55 +/- 0.35 (p = 0.04), respectively. Perfusion to a single affected lung increased from 31 +/- 17% to 46 +/- 14% (p < 0.001). On recatheterization (mean 14 months), results varied minimally. Repeat angioplasty of residual stent stenoses was safe and effective. Complications included four early patients with stent migration, three with stent thrombosis and two deaths. There were no late complications. Significant restenosis occurred in only three patients. CONCLUSIONS: Intravascular stents for the treatment of vascular stenoses in congenital heart disease provide excellent immediate and long-term results.


Asunto(s)
Cardiopatías Congénitas/cirugía , Arteria Pulmonar/anomalías , Arteria Pulmonar/cirugía , Stents , Adolescente , Adulto , Niño , Preescolar , Constricción Patológica , Femenino , Migración de Cuerpo Extraño/etiología , Humanos , Lactante , Masculino , Stents/efectos adversos , Trombosis/etiología , Resultado del Tratamiento
8.
J Am Coll Cardiol ; 11(1): 133-8, 1988 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-2961793

RESUMEN

Balloon dilation is effective in the immediate relief of obstruction due to unoperated coarctation of the aorta. However, the long-term benefits and complications of this procedure have not been established. Thirty-three patients underwent balloon dilation of unoperated coarctation using a percutaneous technique from November 1983 to December 1985. High quality biplane angiography was performed before and after dilation. Follow-up was obtained in 20 patients from 6 to 31 months following dilation. Angiography was performed at follow-up in 10, nuclear magnetic resonance (NMR) imaging in 10 and both NMR imaging and angiography in 3. Balloon dilation was successful in 31 of the 33 patients with a decrease in average systolic pressure gradient from 46 to 8 mm Hg. There was no significant change in gradient on follow-up physical examination and at recatheterization in 10 patients. In addition, there was no evidence of restenosis on follow-up angiography and NMR imaging. In two patients, a small aneurysm formed at the site of balloon dilation. Balloon dilation of unoperated coarctation is effective, providing lasting relief of coarctation gradient and no evidence of restenosis. However, because of the uncertain natural history of aneurysms after dilation, this procedure should be considered investigational until further follow-up on patients with and without an aneurysm is available.


Asunto(s)
Angioplastia de Balón , Coartación Aórtica/terapia , Angiografía , Aorta Torácica/patología , Coartación Aórtica/complicaciones , Presión Sanguínea , Niño , Angiografía Coronaria , Estudios de Seguimiento , Humanos , Imagen por Resonancia Magnética , Recurrencia , Factores de Tiempo
9.
J Am Coll Cardiol ; 10(1): 107-14, 1987 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-2955014

RESUMEN

Despite the generally excellent success with balloon dilation for the stenotic lesions of congenital and acquired heart disease, technical difficulties sometimes prevent satisfactory results. Such technical difficulties include: a large diameter of the anulus of the stenotic lesion relative to available balloon diameter, difficulty in the insertion or removal of the larger balloon catheters, and permanent damage to or obstruction of the femoral vessels by the redundant deflated balloon material of the large balloons. A double balloon technique was initiated to resolve these difficulties. With this method, percutaneous balloon angioplasty catheters were inserted in right and left femoral vessels, placed side by side across the stenotic lesion and inflated simultaneously. Dilation procedures using the two balloon technique were performed in 41 patients: 18 with pulmonary valve stenosis, 14 with aortic valve stenosis, 5 with mitral valve stenosis, 3 with vena caval obstruction following the Mustard or Senning procedure and 1 with tricuspid valve stenosis. Patient ages ranged from 1 to 75 years (mean 17.8) and patient weights ranged from 8.9 to 89 kg (mean 42.3). Balloon catheter sizes ranged from 10 to 20 mm in diameter. Average maximal pressure gradient in mm Hg before dilation was 61 in pulmonary stenosis, 68 in aortic stenosis, 21 in mitral stenosis, 12 in tricuspid stenosis and 25 in vena caval stenosis. Average maximal valvular pressure gradient after dilation was 13 in pulmonary stenosis, 24 in aortic stenosis, 4 in mitral stenosis, 0 in tricuspid stenosis, and 1 in vena caval stenosis. No major complications were encountered with the procedures.(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Angioplastia de Balón/métodos , Enfermedad Coronaria/terapia , Cardiopatías Congénitas/complicaciones , Cardiopatías/complicaciones , Enfermedades de las Válvulas Cardíacas/terapia , Adolescente , Adulto , Anciano , Angioplastia de Balón/instrumentación , Niño , Preescolar , Constricción Patológica/terapia , Enfermedad Coronaria/etiología , Humanos , Lactante , Persona de Mediana Edad , Enfermedades Vasculares/terapia , Venas Cavas
10.
J Am Coll Cardiol ; 12(2): 476-9, 1988 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-3392342

RESUMEN

To assess the usefulness of balloon valvuloplasty in patients with a dysplastic pulmonary valve, the files of 36 patients (aged 1 day to 18.5 years) who had two-dimensional echocardiography before and continuous wave Doppler echocardiography late after balloon valvuloplasty (balloon diameter greater than or equal to 20% anulus diameter) were reviewed. Results of relief of pulmonary stenosis were graded by catheter gradient in the catheterization laboratory and compared with Doppler echocardiographic findings at follow-up. There were 32 patients with typical pulmonary stenosis and 4 with a dysplastic valve. In the 32 patients with typical pulmonary stenosis, transvalvular gradient changed from a mean of 67 +/- 32 to 20 +/- 20 mm Hg (p less than 0.0001, mean reduction 72.6%). The gradients at follow-up by Doppler echocardiography averaged 20 mm Hg including 15 that increased, 3 that were unchanged and 14 that decreased. Only 3 (9%) of 32 patients had a gradient greater than 25 mm Hg at follow-up and only one gradient was greater than 35 mm Hg. All four patients with a dysplastic valve had a gradient that decreased with valvuloplasty from a mean of 85 +/- 33 to 33 +/- 20 mm Hg (p less than 0.05); gradient reduction in this group ranged from 40 to 85% (mean 57.5%). The gradient at follow-up increased in three of these four patients and decreased in one (the only late gradient less than 25 mm Hg). Late gradient was less than 35 mm Hg in two of the four patients and was reduced by 43 and 57%, respectively, in the other two.(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Cateterismo , Ecocardiografía , Estenosis de la Válvula Pulmonar/terapia , Adolescente , Niño , Preescolar , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/congénito , Estenosis de la Válvula Pulmonar/patología , Estenosis de la Válvula Pulmonar/fisiopatología
11.
Am J Cardiol ; 45(1): 98-107, 1980 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-7350779

RESUMEN

Eight cases of mucocutaneous lymph node syndrome with cardiovascular complications are described. The clinical presentation in all but one patient conformed to the previously described features of this syndrome. Five patients had cardiac enlargement, six had electrocardiographic abnormalities and three had a murmur of mitral insufficiency. Each of the four patients who died had aneurysms of the coronary arteries, usually associated with organizing thrombi. In addition to involvement of the coronary arteries, the renal, mesenteric, vertebral, splenic, hepatic and iliac arteries were affected to individual cases. One patient required triple aortocoronary bypass surgery and one patient underwent excision of a brachial arterial aneurysm. Further long-term follow-up studies of the patients who have survived the acute stage of the syndrome are indicated to establish this spectrum of late complications and sequelae.


Asunto(s)
Enfermedades Cardiovasculares/complicaciones , Enfermedades Linfáticas/complicaciones , Síndrome Mucocutáneo Linfonodular/complicaciones , Corticoesteroides/uso terapéutico , Anticoagulantes/uso terapéutico , Arteriopatías Oclusivas/cirugía , Aspirina/uso terapéutico , Preescolar , Vasos Coronarios/patología , Vasos Coronarios/cirugía , Electrocardiografía , Femenino , Aneurisma Cardíaco/diagnóstico , Humanos , Lactante , Masculino , Síndrome Mucocutáneo Linfonodular/diagnóstico , Síndrome Mucocutáneo Linfonodular/patología , Pronóstico
12.
Am J Cardiol ; 35(2): 288-92, 1975 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-47222

RESUMEN

His bundle electrograms were recorded in two children with cardiac conduction disturbances. In the surface electrocardiograms of one patient His bundle extrasystoles mimicked atrial nonconducted bigeminal rhythms; in the other, they simulated second degree atrioventricular (A-V) block and conducted junctional extrasystoles. In both instances the conduction disturbance was a result of concealed conduction of the His bundle extrasystole into the A-V junction. We conclude that the surface electrocardiogram is suggestive but not definitive in diagnosing His bundle extrasystoles and that His bundle recordings are indispensable for correct diagnosis and treatment.


Asunto(s)
Fascículo Atrioventricular , Complejos Cardíacos Prematuros/diagnóstico , Sistema de Conducción Cardíaco , Cardiopatías Congénitas/complicaciones , Complejos Cardíacos Prematuros/fisiopatología , Niño , Preescolar , Dextrocardia/complicaciones , Diagnóstico Diferencial , Electrocardiografía , Femenino , Bloqueo Cardíaco/diagnóstico , Sistema de Conducción Cardíaco/fisiopatología , Insuficiencia Cardíaca/complicaciones , Humanos , Tetralogía de Fallot/complicaciones
13.
Am J Cardiol ; 38(4): 448-51, 1976 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-184705

RESUMEN

Pacemaker recovery time corrected for cycle length was measured in 24 patients 6 months to 3 years after the Mustard operation for transposition of the great arteries. This index of sinoatrial (S-A) nodal function was obtained by subtracting the control R-R interval from the first R-R interval recorded after 3 minutes of rapid atrial pacing at the superior vena caval-right atrial junction. Recovery times were compared with those of a control group of 54 children with various forms of congenital heart disease who had not had cardiac surgery and whose electrocardiogram revealed normal sinus rhythm. The longest corrected pacemaker recovery time in the control group was 250 msec. Recovery time was normal (mean 115 msec) in 13 of the 24 patients who had undergone the Mustard procedure and prolonged (mean 472 msec) in the other 11. In 4 of these 11 a junctional escape complex was recorded before recovery of the S-A node. The configuration of the P wave and the development of dysrhythmias in the postoperative follow-up period were compared in patients with a normal and a prolonged corrected pacemaker recovery time. The incidence of dysrhythmias was much smaller in the former group. Normal sinus rhythm after the first postoperative week was noted in 10 (76 percent) of patients with a normal corrected pacemaker recovery time but in only 2 (18 percent) of those with an abnormal recovery time. One patient with an abnormal recovery time died suddenly 26 months after operation in spite of good hemodynamic repair. A prolonged pacemaker recovery time after the Mustard operation for transposition of the great arteries indicated that rhythm abnormalities were likely to develop, but a normal recovery time did not exclude abnormal sinus nodal function.


Asunto(s)
Transposición de los Grandes Vasos/cirugía , Adolescente , Adulto , Arritmias Cardíacas/fisiopatología , Arterias/cirugía , Niño , Preescolar , Potenciales Evocados , Estudios de Seguimiento , Humanos , Lactante , Periodo Refractario Electrofisiológico , Nodo Sinoatrial/fisiopatología , Transmisión Sináptica
14.
Am J Cardiol ; 45(3): 573-82, 1980 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-7188824

RESUMEN

Fourteen patients who had a left ventricular apex to abdominal aorta composite conduit implanted for relief of severe left ventricular outflow tract obstruction were studied at cardiac catheterization 7 days to 19 months postoperatively (median 12 days). Analysis of pressure, angiographic and blood flow velocity data showed the following: (1) The left ventricle to aorta pressure gradients were reduced from an average preoperative value of 100.6 mmHg (range 54 to 140) to an average of 22.1 mm Hg (range 0 to 60) postoperatively; (2) postoperative left ventricular end-diastolic volume averaged 87.5 percent of normal (range 51 to 146); (3) cardiac index and ejection fraction were normal postoperatively in all but one patient. Left ventricular and aortic angiography revealed blood flow through both the ascending aorta and conduit in all patients and retrograde flow of blood from the conduit to the aortic arch in four. An average of 36 percent (range 16 to 50) of the left ventricular output was ejected through the conduit. It appears that this operation is effective in relieving severe and otherwise inoperable left ventricular outflow tract obstruction and in preserving or improving left ventricular function and aortic hemodynamics.


Asunto(s)
Aorta Abdominal/cirugía , Estenosis Aórtica Subvalvular/cirugía , Prótesis Vascular , Cardiomiopatía Hipertrófica/cirugía , Ventrículos Cardíacos/cirugía , Hemodinámica , Complicaciones Posoperatorias/diagnóstico , Adolescente , Adulto , Anciano , Velocidad del Flujo Sanguíneo , Presión Sanguínea , Gasto Cardíaco , Niño , Preescolar , Femenino , Prótesis Valvulares Cardíacas , Ventrículos Cardíacos/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Contracción Miocárdica , Complicaciones Posoperatorias/mortalidad , Radiografía
15.
Am J Cardiol ; 78(6): 721-3, 1996 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-8831421

RESUMEN

A 2-month-old child with Down syndrome and a large patent ductus arteriosus underwent transcatheter closure using a new Food and Drug Administration-approved occlusion device. This device is described, along with its usefulness for other vascular defects.


Asunto(s)
Cateterismo Cardíaco/instrumentación , Conducto Arterioso Permeable/terapia , Diseño de Equipo , Humanos , Lactante
16.
Am J Cardiol ; 85(9): 1159-61, A9, 2000 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-10781774

RESUMEN

Premature foramen ovale (FO) closure has been postulated as a cause of hypoplastic left heart syndrome. We suggest that premature FO closure is also associated with left ventricular (LV) dilation and LV thrombus formation, and that FO closure in patients with aortic stenosis and LV dilation is a secondary event that occurs later in gestation than that seen with the hypoplastic left heart.


Asunto(s)
Estenosis de la Válvula Aórtica/fisiopatología , Trombosis Coronaria/fisiopatología , Muerte Fetal , Tabiques Cardíacos/fisiopatología , Ventrículos Cardíacos/patología , Dilatación Patológica , Humanos , Masculino
17.
Am J Cardiol ; 57(13): 1131-6, 1986 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-3706165

RESUMEN

Restriction to systemic blood flow at the atrial level in total anomalous pulmonary venous connection (TAPVC) may play a role in the early development of congestive heart failure in some patients. Over a 4-year period, 21 patients with TAPVC without extracardiac obstruction presented from 1 day to 10 months of age (mean 2.6 months). Of 21 patients, 17 (81%) presented after 1 month of age with moderate to severe congestive heart failure. In the first week after birth 4 patients presented with minimal symptoms of congestive heart failure. A small patent foramen ovale (3 mm or less in diameter) was found in 19 of 21 patients (90%) by 2-dimensional echocardiography or angiography. Balloon or blade and balloon atrial septostomy was performed in these 19 patients and resulted in significant decreases in mean right to left atrial pressure gradient (from 2.8 to 0.25 mm Hg, p less than 0.001), systolic pulmonary to femoral artery pressure ratio (from 0.80 to 0.60, p less than 0.001), and systemic arterial oxygen saturation (from 84% to 79%, p less than 0.01). One patient had nonfatal complications. Surgery was performed in 19 patients from 2 weeks to 29 months (mean 12 months) after catheterization, with 1 operative death (5% mortality). Four patients required early total correction because of persistent heart failure; 15 had elective surgical repair. One of 2 unoperated patients died of pneumonia at 2.5 years of age. A restrictive interatrial communication develops after the first month of extrauterine life in most patients with TAPVC. Atrial septostomy results in improved hemodynamic conditions and clinical palliation.(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Circulación Coronaria , Cardiopatías Congénitas/diagnóstico , Venas Pulmonares/anomalías , Cateterismo Cardíaco , Ecocardiografía , Atrios Cardíacos/fisiopatología , Cardiopatías Congénitas/cirugía , Insuficiencia Cardíaca/etiología , Hemodinámica , Humanos , Lactante , Recién Nacido , Venas Pulmonares/cirugía
18.
Am J Cardiol ; 43(3): 581-5, 1979 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-420107

RESUMEN

Dobutamine is useful for augmenting cardiovasuclar function in adults. However, no information is available on the action of dobutamine in children. To determine its hemodynamic effects in children, we infused dobutamine into 12 children with congenital heart disease during diagnostic cardiac catheterization. We administered dobutamine in two doses: first 2 and then 7.75 microgram/kg per min for 10 minutes each. We meaured heart rate, cardiac output, systemic and pulmonary arterial, right atrial and pulmonary capillary blood pressures before and during the infusion of dobutamine. Systemic and pulmonary vascular resistances, cardiac index and stroke index were calculated. Cardiac output, cardiac index, stroke volume, stroke index and systemic arterial phasic and mean blood pressures increased sugnificantly (P less than 0.05) and pulmonary capillary mean blood pressure decreased significantly (P less than 0.05) during the infusion of each dose of dobutamine compared with control values. Heart rate, pulmonary and right atrial mean blood pressure and systemic and pulmonary vascular resistance were unchanged with either dose of dobutamine. We noted no adverse effect from the drug.


Asunto(s)
Catecolaminas/farmacología , Dobutamina/farmacología , Hemodinámica/efectos de los fármacos , Adolescente , Adulto , Factores de Edad , Presión Sanguínea/efectos de los fármacos , Gasto Cardíaco/efectos de los fármacos , Niño , Preescolar , Dopamina/farmacología , Cardiopatías Congénitas/diagnóstico , Cardiopatías Congénitas/fisiopatología , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Isoproterenol/farmacología , Volumen Sistólico/efectos de los fármacos , Resistencia Vascular/efectos de los fármacos
19.
Am J Cardiol ; 64(3): 218-21, 1989 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-2662746

RESUMEN

The double-disk occluding device suitable for use in infants and children with patent ductus arteriosus, developed by Rashkind and Mullins, has been available to this institution since December 1987 on an investigational basis. Results of 43 nonsurgical ductal closure attempts using this device in children and young adults between December 1987 and October 1988 are presented. Successful implantation was achieved in 42 patients (98%). In 25 patients a residual shunt was seen on angiography immediately after implantation. In 12 patients a residual ductal shunt was detected by Doppler 24 hours after implantation; 6-week follow-up studies showed a small residual shunt in only 3 patients. After a second occluder device was implanted in 2 of these patients, complete closure of the patient ductus arteriosus was achieved. In 1 patient, early in the series, the occluder device embolized to the left pulmonary artery, necessitating surgical removal at the time of ductus division. This event was the only serious complication; there were no deaths.


Asunto(s)
Conducto Arterioso Permeable/terapia , Prótesis e Implantes , Adolescente , Adulto , Cateterismo , Niño , Preescolar , Conducto Arterioso Permeable/diagnóstico , Femenino , Estudios de Seguimiento , Humanos , Masculino , Ultrasonografía
20.
Am J Cardiol ; 85(5): 636-40, 2000 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-11078280

RESUMEN

The aim of this study was to review contemporary techniques, devices, and results of transcatheter occlusion of surgical shunts in 2 pediatric cardiac programs. Closure of superfluous surgical shunts may reduce cardiac work and risk of endocarditis. Previous studies have shown that transcatheter closure of shunts is feasible, but have not demonstrated acceptable efficacy or safety. In addition, the performance of new techniques and devices has not been reviewed. Between 1993 and 1998, 18 patients with congenital heart disease underwent transcatheter closure of 19 Blalock-Taussig shunts. Detachable and standard Gianturco coils and Gianturco-Grifka vascular occlusion devices were employed. All 19 shunts had complete closure. Eight shunts had initial placement of detachable coils. Five shunts had stents placed that bridged the pulmonary end of the shunts. These 5 and 4 additional shunts had closure by standard coils. Two shunts were closed with Gianturco-Grifka devices. There were no complications, no embolizations, and no requirement for surgery precipitated by the procedures. This review of contemporary techniques, devices, and results suggests that transcatheter occlusion of surgical shunts is effective and safe.


Asunto(s)
Cateterismo Cardíaco , Procedimientos Quirúrgicos Cardíacos , Embolización Terapéutica , Cardiopatías Congénitas/cirugía , Implantación de Prótesis Vascular/métodos , Preescolar , Embolización Terapéutica/instrumentación , Humanos , Reoperación , Stents
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