Sensory processing challenges as a novel link between early caregiving experiences and mental health.

Early caregiving adversity (ECA) is associated with elevated psychological symptomatology. While neurobehavioral ECA research has focused on socioemotional and cognitive development, ECA may also increase risk for "low-level" sensory processing challenges. However, no prior work has compared how diverse ECA exposures differentially relate to sensory processing, or, critically, how this might influence psychological outcomes. We examined sensory processing challenges in 183 8-17-year-old youth with and without histories of institutional (orphanage) or foster caregiving, with a particular focus on sensory over-responsivity (SOR), a pattern of intensified responses to sensory stimuli that may negatively impact mental health. We further tested whether sensory processing challenges are linked to elevated internalizing and externalizing symptoms common in ECA-exposed youth. Relative to nonadopted comparison youth, both groups of ECA-exposed youth had elevated sensory processing challenges, including SOR, and also had heightened internalizing and externalizing symptoms. Additionally, we found significant indirect effects of ECA on internalizing and externalizing symptoms through both general sensory processing challenges and SOR, covarying for age and sex assigned at birth. These findings suggest multiple forms of ECA confer risk for sensory processing challenges that may contribute to mental health outcomes, and motivate continuing examination of these symptoms, with possible long-term implications for screening and treatment following ECA.

Revisiting the Neural Architecture of Adolescent Decision-Making: Univariate and Multivariate Evidence for System-Based Models.

Understanding adolescent decision-making is significant for informing basic models of neurodevelopment as well as for the domains of public health and criminal justice. System-based theories posit that adolescent decision-making is guided by activity amongst reward and control processes. While successful at explaining behavior, system-based theories have received inconsistent support at the neural level, perhaps because of methodological limitations. Here, we used two complementary approaches to overcome said limitations and rigorously evaluate system-based models. Using decision-level modeling of fMRI data from a risk-taking task in a sample of 2000+ decisions across 51 human adolescents (25 females, mean age = 15.00 years), we find support for system-based theories of decision-making. Neural activity in lateral prefrontal cortex and a multivariate pattern of cognitive control both predicted a reduced likelihood of risk-taking, whereas increased activity in the nucleus accumbens predicted a greater likelihood of risk-taking. Interactions between decision-level brain activity and age were not observed. These results garner support for system-based accounts of adolescent decision-making behavior.SIGNIFICANCE STATEMENT:Adolescent decision-making behavior is of great import for basic science, and carries equally consequential implications for public health and criminal justice. While dominant psychological theories seeking to explain adolescent decision-making have found empirical support, their neuroscientific implementations have received inconsistent support. This may be partly due to statistical approaches employed by prior neuroimaging studies of system-based theories. We used brain modeling-an approach that predicts behavior from brain activity-of univariate and multivariate neural activity metrics to better understand how neural components of psychological systems guide decision behavior in adolescents. We found broad support for system-based theories such that neural systems involved in cognitive control predicted a reduced likelihood to make risky decisions, whereas value-based systems predicted greater risk-taking propensity.

Emotion regulation strategy usage explains links between institutional caregiving and elevated internalizing symptoms.

Early adversity, including institutional orphanage care, is associated with the development of internalizing disorders. Previous research suggests that institutionalization can disrupt emotion regulation processes, which contribute to internalizing symptoms. However, no prior work has investigated how early orphanage care shapes emotion regulation strategy usage (e.g., cognitive reappraisal, expressive suppression) and whether the said strategy usage contributes to internalizing symptoms. This study probed emotion regulation strategy usage and internalizing symptoms in a sample of 36 previously institutionalized and 58 comparison youth. As hypothesized, previously institutionalized youth exhibited higher rates of internalizing symptoms than comparison youth, and more frequent use of suppression partially accounted for the relationship between early institutional care and elevated internalizing symptoms. Contrary to our initial hypotheses, reappraisal use did not buffer previously institutionalized or comparison youth against internalizing symptoms. Our findings highlight the potential utility of targeting emotion regulation strategy usage in adversity-exposed youth in future intervention work.

A data-driven typology of emotion regulation profiles.

Typologies serve to organize knowledge and advance theory for many scientific disciplines, including more recently in the social and behavioral sciences. To date, however, no typology exists to categorize an individual's use of emotion regulation strategies. This is surprising given that emotion regulation skills are used daily and that deficits in this area are robustly linked with mental health symptoms. Here, we attempted to identify and validate a working typology of emotion regulation across six samples (collectively comprised of 1,492 participants from multiple populations) by using a combination of computational techniques, psychometric models, and growth curve modeling. We uncovered evidence for three types of regulators: a type that infrequently uses emotion regulation strategies (Lo), a type that uses them frequently but indiscriminately (Hi), and a third type that selectively uses some (cognitive reappraisal and situation selection), but not other (expressive suppression), emotion regulation strategies frequently (Mix). Results showed that membership in the Hi and Mix types is associated with better mental health, with the Mix type being the most adaptive of the three. These differences were stable over time and across different samples. These results carry important implications for both our basic understanding of emotion regulation behavior and for informing future interventions aimed at improving mental health. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Performance and belief-based emotion regulation capacity and tendency: Mapping links with cognitive flexibility and perceived stress.

Cognitive reappraisal is among the most effective and well-studied emotion regulation strategies humans have at their disposal. Here, in 250 healthy adults across 2 preregistered studies, we examined whether reappraisal capacity (the ability to reappraise) and tendency (the propensity to reappraise) differentially relate to perceived stress. We also investigated whether cognitive flexibility, a skill thought to support reappraisal, accounted for associations between reappraisal capacity and tendency and perceived stress but found no evidence for this hypothesis. Both Studies 1 and 2 robustly showed that reappraisal tendency was associated with perceived stress, whereas a significant relationship between reappraisal capacity and perceived stress was only observed in Study 2. Further, Study 2 suggested that self-reported beliefs about one's emotion regulation capacity and tendency were predictive of wellbeing, whereas no such associations were observed with performance-based assessments of capacity and tendency. These data suggest that self-reported perceptions of reappraisal skills may be more predictive of wellbeing than actual reappraisal skills. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Early caregiving adversity differentially shapes behavioral sensitivity to reward and risk during decision-making.

Cognitive systems that track, update, and utilize information about reward (consequences) and risk (uncertainty) are critical for adaptive decision-making as well as everyday functioning and well-being. However, it remains unclear how individual differences in reward and risk sensitivity are independently shaped by environmental influences and give rise to decision-making. Here, we investigated the impact of early life experience-a potent sculptor of development-on behavioral sensitivity to reward and risk. We administered a widely used decision-making paradigm to 55 adolescents and young adults who were exposed to early deprivation in the form of early institutional (orphanage) care (a type of early life adversity) and 81 comparison individuals who were reared by their biological parents and did not experience institutional care. Leveraging random coefficient regression and computational models, we observed that previously institutionalized individuals displayed general reward hyposensitivity, contributing to a decreased propensity to make decisions that stood to earn relatively large rewards relative to comparison individuals. By contrast, group differences in risk sensitivity were selectively observed on loss, but not gain, trials. These results are the first to independently and explicitly link early experiences to reward and risk sensitivity during decision-making. As such, they lay the groundwork for therapeutic efforts to identify and treat adversity-exposed individuals at risk for psychiatric disorders characterized by aberrant decision-making processes. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

With a little help from my friends: Selective social potentiation of emotion regulation.

Decades of research has pointed to emotion regulation (ER) as a critical ingredient for health, well-being, and social functioning. However, the vast majority of this research has examined ER in a social vacuum, despite the fact that in everyday life individuals frequently regulate their emotions with help from other people. The present collection of preregistered studies examined whether social help increases the efficacy of reappraisal, a widely studied ER strategy that involves changing how one thinks about emotional stimuli. In Study 1 (N = 40 friend pairs), we compared the efficacy of reinterpreting the content of negative stimuli alone (solo ER) to listening to a friend reinterpret the stimuli (social ER). We found that social ER was more effective than solo ER, and that the efficacy of these strategies was correlated within individuals. In Studies 2 and 3, we replicated effects from Study 1, and additionally tested alternate explanations for our findings. In Study 2 (N = 40 individuals), we failed to find evidence that social ER was more effective than solo ER due to a difference in the quality of reinterpretations, and in Study 3 (N = 40 friend pairs), we found that social help did not significantly attenuate negative affect in the absence of reappraisal. In sum, we found that social help selectively potentiates the efficacy of reappraisal, and that this effect was not merely the outcome of social buffering. Together, these results provide insight into how social relationships can directly lend a hand in implementing ER strategies. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Longitudinal changes in brain structures related to appetitive reactivity and regulation across development.

In the United States over one-third of the population, including children and adolescents, are overweight or obese. Despite the prevalence of obesity, few studies have examined how food cravings and the ability to regulate them change throughout development. Here, we addressed this gap in knowledge by examining structural brain and behavioral changes associated with regulation of craving across development. In a longitudinal design, individuals ages 6-26 completed two structural scans as well as a behavioral task where they used a cognitive regulatory strategy to decrease the appetitive value of foods. Behaviorally, we found that the ability to regulate craving improved with age. Neurally, improvements in regulatory ability were associated with cortical thinning in medial and lateral prefrontal cortex. We also found that models with cortical thickness measurements and age chosen by a lasso-based variable selection method could predict an individual's regulation behavior better than age and other behavioral factors alone. Additionally, when controlling for age, smaller ventral striatal volumes were associated with higher body mass index and predicted greater increases in weight two years later. Taken together, these results demonstrate a role for structural brain changes in supporting the ability to resist cravings for appetitive foods across development.