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1.
Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling.
Bioorg Med Chem
; 24(10): 2215-34, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27085672
2.
Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg Med Chem Lett
; 22(17): 5714-20, 2012 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22832322
3.
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
J Med Chem
; 65(6): 4972-4990, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35286090
4.
3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation.
Bioorg Med Chem Lett
; 21(11): 3384-9, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21514825
5.
Corrigendum to "Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling" [Bioorg. Med. Chem. 24 (2016) 2215-2234].
Bioorg Med Chem
; 24(13): 3093, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27234892
6.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31820981
7.
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists.
Mol Pain
; 3: 39, 2007 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-18086308
8.
Novel vanilloid receptor-1 antagonists: 1. Conformationally restricted analogues of trans-cinnamides.
J Med Chem
; 50(15): 3497-514, 2007 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17585749
9.
Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.
J Med Chem
; 50(15): 3528-39, 2007 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17585751
10.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
J Med Chem
; 58(11): 4462-82, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25914941
11.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N â S (nN â σ*S-X) Interaction for Conformational Constraint.
J Med Chem
; 58(24): 9663-79, 2015 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26551034
12.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
J Med Chem
; 57(7): 3094-116, 2014 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24611879
13.
Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.
J Med Chem
; 57(7): 2989-3004, 2014 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24597733
14.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J Med Chem
; 57(2): 325-38, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405213
15.
Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.
J Med Chem
; 55(4): 1593-611, 2012 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-22329507
16.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem
; 55(11): 5188-219, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22548365
17.
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
J Med Chem
; 55(17): 7796-816, 2012 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22897589
18.
Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.
J Med Chem
; 54(13): 4735-51, 2011 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21612232
19.
Versatile diastereoselectivity in formal [3,3]-sigmatropic shifts of substituted 1-alkenyl-3-alkylidenecyclobutanols and their silyl ethers.
J Am Chem Soc
; 127(32): 11206-7, 2005 Aug 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-16089425
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