1.
J Am Chem Soc
; 131(34): 12072-3, 2009 Sep 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19655742
RESUMEN
The proposed structure of the maduropeptin chromophore, the biologically active component of the highly potent chromoprotein antitumor antibiotics, was stereoselectively synthesized but did not satisfy the spectra of the natural product. We demonstrated that the correct structure is diastereomeric, which possesses an antipodal sugar moiety.
Asunto(s)
Enediinos/química , Enediinos/síntesis química
2.
Chem Commun (Camb)
; (42): 5372-4, 2008 Nov 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18985214
RESUMEN
In the Masamune-Bergman cyclization of a nine-membered non-conjugated enediyne with an internal, maduropeptin-like nucleophile, the exocyclic alkene migrated to form the nine-membered conjugated enediyne, triggered by the intramolecular addition of the amide group; final aromatized products showed up to 85% yield.