Understanding how management can prevent degradation of the structurally fragile soils of the Amazonian periphery.

The dynamics and responses to mulching management processes, which affect sustainability in tropical agroecosystems, remain poorly understood. Therefore, this study aims to evaluate and distinguish the short-and long-term effects of mulch of leguminous biomass on fertility of a tropical soil enriched with calcium. This experiment was conducted using the treatments: Long-term mulching (LTM) consisted of planting without mulch in 2019 in soil that had been mulched for six years previously, while short-term mulching (STM) consisted of planting without mulch for six years and with mulch only in 2019. LTM + STM consisted of planting in mulched soil for seven years (from 2013 to 2019), while LTM + synthetic nitrogen (LTM + sN) consisted of the LTM treatment with the addition of 150 kg N ha-1. The remaining treatments were STM + sN; LTM + STM + sN; bare soil with sN, and bare soil without sN as control. In areas with LTM the interactions between products derived from biomass, sN, and Ca resulted in higher total SOC and BS, while STM maintained soil moisture, decreased penetration resistance, and enhanced N uptake providing biological nitrogen able to replace sN for maize nutrition. The positive effects of short- and long-term mulching were cumulative as they increased accumulated N by maize in 163%, and maize grain yield by 125% (4.77-10.78 Mg ha-1) compared to cultivation with sN without mulch. Our results showed that interactions between continuos mulch of leguminous biomass, Ca and sN prevent degradation of agricultural land in Amazonian conditions. Therefore, this combination must be recommended to prevent Amazonian soil management, which in turn reduces the risk of new deforestation in Amazonian periphery.

Enhanced targeted liposomal delivery of imiquimod via aptamer functionalization for head and neck cancer therapy.

The incidence of head and neck cancers, particularly those associated with Human Papillomavirus (HPV) infections, has been steadily increasing. Conventional therapies exhibit limitations and drawbacks, prompting the exploration of new strategies over the years, with nanomedicine approaches, especially liposomes gaining relevance. Additionally, the functionalization of liposomes with aptamers enables selective delivery to target cells. For instance, AT11 can serve as a targeting moiety for cancer cells due to its high affinity for nucleolin, a protein overexpressed on the cancer cell's surface. In this study, liposomes functionalized with AT11 are proposed as drug delivery systems for imiquimod (IQ), aiming to maximize its potential as an anticancer agent for HPV-related cancers. To this end, firstly liposomes were produced through the ethanol injection method, functionalized with AT11-TEG-Cholesteryl, and characterized using dynamic light scattering. The obtained liposomes presented suitable properties for cancer therapy (with sizes from 120 to 140 nm and low polydispersity PDI < 0.16) and were further evaluated in terms of potential anticancer effects. AT11 IQ-associated liposomes allowed a selective delivery of IQ towards a tongue cancer cell line (UPCI-SCC-154) relative to the non-malignant cell line (Het1A). Specifically, they induced a selective reduction of the cell viability (∼52 % versus ∼113 %; p < 0.0001), proliferation (∼68 % versus ∼102 %; p<0.0001) and increased cell death (∼7-fold increase; p < 0.0001)). Additionally, they decreased the migration (from ∼24 % to ∼8 %; p < 0.0001) and invasion (to 11 %; p = 0.0047) capacities of the cancer cells. In summary, the produced liposomes represent a promising approach to enhance the anticancer potential of IQ in head and neck cancer, particularly in tongue cancer.

Cyrene™ as a tyrosinase inhibitor and anti-browning agent.

The tyrosinase pathway takes part in the enzymatic process of food browning and is primarily responsible for food spoilage - manifesting itself from a decrease in its nutritional value to a deterioration of taste, which consequently leads to a gradual loss of shelf life. Finding safe and bio-based tyrosinase inhibitors and anti-browning agents may be of great importance in agriculture and food industries. Herein, we showed that Cyrene™ exhibits tyrosinase inhibitory activity (IC50: 268.2 µM), the 1.44 times higher than ascorbic acid (IC50: 386.5 µM). Binding mode studies demonstrated that the carbonyl oxygen of Cyrene™ coordinates with both copper ions. Surprisingly, both hydroxyl groups of Cyrene gem-diol perform a monodentate binding mode with both copper ions, at similar distances. This fact suggests that both compounds could have a similar binding mode and, as consequence, similar biological activities in tyrosinase inhibition assays and anti-browning activities.

Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia.

Siglec-6 is a lectin receptor with restricted expression in the placenta, mast cells and memory B-cells. Although Siglec-6 is expressed in patients with chronic lymphocytic leukemia (CLL), its pathophysiological role has not been elucidated. We describe here a role for Siglec-6 in migration and adhesion of CLL B cells to CLL- bone marrow stromal cells (BMSCs) in vitro and compromised migration to bone marrow and spleen in vivo. Mass spectrometry analysis revealed interaction of Siglec-6 with DOCK8, a guanine nucleotide exchange factor. Stimulation of MEC1-002 CLL cells with a Siglec-6 ligand, sTn, results in Cdc42 activation, WASP protein recruitment and F-actin polymerization, which are all associated with cell migration. Therapeutically, a Siglec-6/CD3-bispecific T-cell-recruiting antibody (T-biAb) improves overall survival in an immunocompetent mouse model and eliminates CLL cells in a patient derived xenograft model. Our findings thus reveal a migratory role for Siglec-6 in CLL, which can be therapeutically targeted using a Siglec-6 specific T-biAb.

Imiquimod-Loaded Nanosystem for Treatment Human Papillomavirus-Induced Lesions.

Human papillomavirus (HPV)-associated cervical cancer is the most common cancer among women worldwide. The treatment options are strongly related to increased infertility in women. Imiquimod (IQ) is an imidazoquinoline, which has proven antiviral effects against persistent HPV infection by activating immune cells via Toll-like receptors 7/8 when formulated in carriers, like nanogels, for topical use. An effective alternative to conventional therapies is the nanoparticle drug delivery system. We studied lipidic nanoparticles with IQ (Lipo IQ) and functionalized them with a DNA aptamer, AT11 (Lipo IQ AT11), to improve the selectivity for cervical cancer cells combined with the efficacy of essential oils. The formulations showed that the physicochemical properties are adequate for vaginal drug delivery and have antimicrobial activity at higher concentrations (with MIC50 starting from 0.625%). The final formulations exhibited cytotoxicity in cancer cells, enhanced by essential oils without affecting healthy cells, resulting in less than 10% cell viability in HeLa cells and over 60% in NHDF cells. Essential oils potentiate Lipo IQ's effectiveness, while AT11 increases the selectivity for cervical cancer cells. As suggested by the results of the permeation assay, the formulations were internalized by the cancer cells. Overall, the obtained results suggested that the synergistic effect of the essential oils and the nanosystem potentiate the cytotoxic effect of Lipo IQ and that Lipo IQ AT11 promotes selectivity towards cancer cells.

RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation.

Oral cancer incidence and mortality are increasing over time. The most common therapies for oral cancers are surgery and radiotherapy, either used alone or combined, and immunotherapy can be also an option. Although there are several therapeutic options, none of them are completely effective, and in addition, there are numerous associated side effects. To overcome these limitations, researchers have been trying to reduce these drawbacks by using drug delivery systems that carry drugs for specific delivery to cancer cells. For that purpose, RNA-coated liposomes to selectively deliver the ligands C8 (acridine orange derivative) and dexamethasone to oral cancer cells were produced, characterized, and biologically evaluated. Firstly, the RNA structure and binding interaction with ligands (C8 and dexamethasone) were evaluated by circular dichroism (CD), thermal difference spectroscopy (TDS), nuclear magnetic resonance (NMR) and fluorescence titrations. The biophysical assays evidenced the formation of an RNA hairpin and duplex structure. Moreover, steady-state and time-resolved fluorescence intensity and anisotropy experiments show that C8 forms a complex with RNA and adopts an open conformation upon RNA binding. Then, RNA-coated liposomes were characterized by dynamic light scattering, and diameters near 160 nm were observed. Time-resolved anisotropy measurements of C8 loaded in RNA-functionalized liposomes indicate the co-existence of free C8 in solution (inside the liposome) and C8 bound to RNA at the external liposome surface. The RNA-functionalized liposomes loaded with C8 or dexamethasone mediated a significant reduction in the cell viability of malignant UPCI-SCC-154 cells while maintaining viable non-malignant NHDF cells. Additionally, the liposomes were able to internalize the cells, with higher uptake by the malignant cell line. Overall, the results obtained in this work can contribute to the development of new drug delivery systems based on RNA-coated liposomes.

Diagnósticos de enfermagem identificados em homens idosos submetidos à prostatectomia / Nursing diagnoses identified in elderly men submitted to prostatectomy

Objetivo: descrever os diagnósticos de Enfermagem evidenciados em homens idosos no pós-operatório de prostatectomia. Método: trata-se de um estudo misto, descritivo, com 50 homens submetidos à cirurgia de prostatectomia em um hospital filantrópico. Utilizaram-se as etapas: entrevista individual, exame físico completo, leitura de prontuário, identificação de problemas de Enfermagem e avaliação por experts para o levantamento dos diagnósticos de Enfermagem. Tomou-se como base a taxonomia da NANDA Internacional. Organizaram-se os dados no software NVIVO11, apresentando-os em figuras e tabelas. Resultados: identificaram-se os diagnósticos, estilo de vida sedentário, comportamento de saúde propenso a risco, controle ineficaz da saúde, síndrome do idoso frágil, risco de infecção, dentição prejudicada, integridade da pele prejudicada, risco de lesão no trato urinário, risco de mucosa oral prejudicada, risco de contaminação e padrão de sexualidade ineficaz. Conclusão: sugere-se o desenvolvimento de intervenções de enfermagem especializadas com direcionamento ao cuidado integral da saúde do homem idoso no processo de envelhecimento, com atenção focada na garantia da segurança no processo cirúrgico e suas complicações, atenção urológica, afetiva, sexual, promoção e controle da saúde ampliada.(AU)

Objective: to describe the Nursing diagnoses evidenced in elderly men in the postoperative period of prostatectomy. Method: this is a descriptive, mixed study with 50 men undergoing prostatectomy surgery in a philanthropic hospital. The following steps were used: individual interview, complete physical examination, reading of the chart, identification of problems of Nursing and evaluation by experts for the survey of Nursing diagnoses. The taxonomy of NANDA International was taken as a basis. The data was organized in NVIVO11 software, presented in figures and tables. Results: diagnoses were identified, sedentary lifestyle, risk-prone health behavior, ineffective health control, frail elderly syndrome, risk of infection, impaired dentition, impaired skin integrity, risk of urinary tract injury, risk of impaired oral mucosa, risk of contamination and ineffective sexuality pattern. Conclusion: it is suggested the development of specialized nursing interventions aimed at the integral care of elderly men's health in the aging process, focusing on ensuring safety in the surgical process and its complications, urological, affective, sexual, expanded health control.(AU)

Objetivo: describir los diagnósticos de Enfermería evidenciados en hombres ancianos en el postoperatorio de prostatectomía. Método: se trata de un estudio mixto, descriptivo, con 50 hombres sometidos a la cirugía de prostatectomía en un hospital filantrópico. Se utilizaron las etapas: entrevista individual, examen físico completo, lectura de prontuario, identificación de problemas de Enfermería y evaluación por expertos para el levantamiento de los diagnósticos de Enfermería. Se tomó como base la taxonomía de la NANDA Internacional. Se organizaron los datos en el software NVIVO11, presentándolos en figuras y tablas. Resultados: se identificaron los diagnósticos, estilo de vida sedentario, comportamiento de salud propenso a riesgo, control ineficaz de la salud, síndrome del anciano frágil, riesgo de infección, dentición perjudicial, integridad de la piel perjudicada, riesgo de lesión en el tracto urinario, riesgo de mucosa oral perjudicada, riesgo de contaminación y patrón de sexualidad ineficaz. Conclusión: se sugiere el desarrollo de intervenciones de enfermería especializadas con direccionamiento al cuidado integral de la salud del hombre mayor en el proceso de envejecimiento, con atención enfocada en la garantía de la seguridad en el proceso quirúrgico y sus complicaciones, atención urológica, afectiva, sexual, promoción y control de la salud ampliada.(AU)

Vivências no processo de parturição: antagonismo entre o desejo e o medo / Experiencias en el proceso de parturición: antagonismo entre el deseo y el miedo / Experiences on the childbirth process: antagonism between desire and fear

Objetivo: Discutir a vivência de mulheres no processo de parturição. Método: Estudo descritivo, qualitativo, realizado em um Centro Municipal de Saúde no Rio de Janeiro, em 2015, com 17 mulheres com até 42 dias de pós-parto. Empregou-se a técnica de entrevista semiestruturada e a técnica de análise de conteúdo na modalidade temático-categorial. Resultados: As participantes são multíparas, o parto realizado em maternidades públicas, e não receberam orientação no pré-natal sobre a parturição. Sentiram-se acolhidas, relacionaram a dor das contrações uterinas ao sofrimento físico, durante o trabalho de parto tiveram a opção de ingerir alimentos e água, adotaram a posição de litotomia, e o parceiro participou como acompanhante. Os profissionais de saúde, todavia, assumiram uma postura de controle sobre seus corpos no processo de parturição. Conclusão: Os resultados ratificam a importância de os casais serem orientados sobre a gestação e o parto, para que possam vivenciá-los de forma ativa e segura

Objective: To discuss the experience of women in the parturition process. Method: A descriptive, qualitative study conducted at a Municipal Health Center in Rio de Janeiro in 2015, with 17 women with up to 42 days postpartum. The technique of semi-structured interview was used, as well as the technique of content analysis in the thematic categorical modality. Results: Participants were multipara, childbirth occurred in public maternity hospitals, and they did not receive prenatal orientation on parturition. They felt welcomed, related the pain of uterine contractions to physical suffering, during labor they had the option of ingesting food and water, adopted the lithotomy position, and the partner participated as companion. Health professionals, however, took a controlling stance on their bodies in the parturition process. Conclusion: The results confirm the importance of couples being oriented on gestation and childbirth in order to experience childbirth in an active and safe way

Objetivo: Analizar la experiencia de mujeres en el proceso de parturición. Método: Estudio descriptivo, cualitativo, realizado en un Centro Municipal de Salud de Rio de Janeiro, en 2015, con 17 mujeres con hasta 42 días de posparto. Se utilizó la técnica de entrevista semiestructurada y la técnica de análisis de contenido en la modalidad temático-categorial. Resultados: Las participantes son multíparas, el parto realizado en maternidades públicas, y no recibieron orientación en el prenatal sobre la parturición. Se sintieron acogidas, vincularon el dolor de las contracciones uterinas AL sufrimiento físico, durante el trabajo de parto tuvieron la opción de ingerir alimentos y agua, adoptaron la posición de litotomía, y el compañero participó como acompañante. Los profesionales de salud, sin embargo, asumieron una postura de control sobre sus cuerpos en el proceso de parturición. Conclusión: Los resultados confirman la importancia de que las parejas reciban orientación sobre la gestación y el parto, para que puedan experimentar el parto de forma activa y segura

Um mapeamento de teses e dissertações sobre ginástica rítmica no Brasil / A mapping of theses and dissertations about rhythmic gymnastics in Brazil / Un mapeo de tesis y disertaciones sobre la gimnasia rítmica en Brasil

A Ginástica Rítmica tem crescido dentro dos países e tem instigado novas produções científicas. Diante disso, o presente estudo tem como objetivo identificar o perfil das teses e dissertações sobre a modalidade indexadas em bases de dados nacionais. O caminho metodológico percorrido possui caráter exploratório e descritivo. Procurou-se evidenciar e caracterizar as instituições envolvidas nas produções sobre a modalidade e identificar quais são os enfoques temáticos. O escopo do estudo foi composto por 42 produções referentes exclusivamente à Ginástica Rítmica, no período de 1988-2019. Encontrou-se assuntos vinculados à saúde, treinamento, história, estética e formação profissional. Esses cinco assuntos encontrados foram analisados através do Modelo Analítico dos 5E's de Marchi Júnior (2015). Ao final, o presente estudo pôde contribuir com o meio acadêmico ao mapear as teses e dissertações que abordam unicamente a Ginástica Rítmica no Brasil, evidenciando as vertentes menos investigadas e, assim, passíveis de serem temas de novas pesquisas.

Rhythmic Gymnastics has grown within the countries and has instigated new scientific productions. Therefore, this study aims to identify the profile of theses and dissertations on the sport indexed in national databases. The methodological path followed has an exploratory and descriptive character. It was tried to evidence and characterize the institutions involved in the productions about the modality and to identify which are the thematic focuses. The scope of the study was composed of 42 productions related exclusively to Rhythmic Gymnastics, in the period 1988-2019. Subjects related to health, training, history, aesthetics and professional training were found. These five subjects found were analyzed through the 5E's Analytical Model of Marchi Júnior (2015). In the end, this study could contribute to the academic environment by mapping the theses and dissertations that address only the Rhythmic Gymnastics in Brazil evidencing the less investigated aspects and, thus, likely to be subjects of new researches.

La Gimnasia Rítmica ha crecido dentro de los países y ha impulsado nuevas producciones científicas. Por lo tanto, este estudio tiene como objetivo identificar el perfil de las tesis y disertaciones sobre el deporte indexado en las bases de datos nacionales. El camino metodológico seguido tiene un carácter exploratorio y descriptivo. Se trató de evidenciar y caracterizar las instituciones involucradas en las producciones sobre la modalidad e identificar cuáles son los focos temáticos. El ámbito del estudio estuvo compuesto por 42 producciones relacionadas exclusivamente con la Gimnasia Rítmica, en el período 1988-2019. Se encontraron temas relacionados con la salud, el entrenamiento, la historia, la estética y la formación profesional. Estos cinco temas encontrados fueron analizados a través del Modelo Analítico de las 5E's de Marchi Júnior (2015). Al final, este estudio podría contribuir al ámbito académico mediante el mapeo de las tesis y disertaciones que abordan sólo la Gimnasia Rítmica en Brasil evidenciando los aspectos menos investigados y, por lo tanto, susceptibles de ser temas de nuevas investigaciones.

Produtividade de pastagens de Coastcross-1 em consórcio com diferentes leguminosas de ciclo hibernal / Productivity of Coastcross-1 pastures mixed with cool-season legumes

Objetivou-se com esta pesquisa avaliar três sistemas forrageiros constituídos por Coastcross-1 (CC) + 100kg de N ha-1 ano-1 + ervilhaca comum; CC + 100kg de N ha-1 ano-1 + trevo vesiculoso; e CC + 200kg de N ha-1 ano-1. Durante o período experimental (345 dias), foram realizados treze pastejos. Para avaliação, foram utilizadas vacas em lactação da raça Holandesa. Foram avaliadas a massa de forragem, composição botânica, relação folha/colmo; taxa de acúmulo diário, produção e consumo de forragem; eficiência de pastejo e taxa de lotação. Os valores médios de produção de forragem e lotação foram de 21,0; 20,3 e 24,3t ha-1; 7,0; 6,5 e 7,7 unidades animais ha-1 dia-1, para os respectivos sistemas forrageiros. Melhores resultados foram obtidos no consórcio de CC com ervilhaca e no cultivo singular de CC.

The objective of this research was to evaluate three grazing systems with Coastcross-1 (CC) + 100kg N ha-1 year-1 + common vetch; CC + 100kg N ha-1 year-1 + arrowleaf clover; and CC + 200kg N ha-1 year-1. Thirteen grazing cycles were performed during the experimental period (345 days). Lactating Holstein cows were used in the evaluation. The forage mass, botanical composition, leaf/stem ratio; daily accumulation rate, production and forage intake; grazing efficiency and stocking rate were evaluated. The average of forage production and stocking rate were 21.0, 20.3, 24.3t ha-1 and 7.0, 6.5, 7.7 animal units ha-1 day-1 for the respective forage systems. Better results were found on Coastcross-1 mixed with common vetch and Coastcross-1 alone.

Chemical constituents and pharmacological profile of Gunnera manicata L. extracts

Gunnera perpensa L. (Gunneraceae) is a native South African plant widely used in traditional medicine as an antibacterial and antifungal. In southern Brazil there is the native species called Gunnera manicata L. that also belongs to the Gunneraceae. Nevertheless, there is no information about chemical and pharmacological properties of South American Gunnera species. Therefore this study aimed at assessing the phytochemical and pharmacological profiles of aqueous and methanol Brazilian G. manicata extracts. The results showed that antimicrobial activity in an agar diffusion assay was effective against Staphylococcus aureus and Candida albicans . Phenolic compounds were investigated by liquid chromatography coupled with a tandem mass spectrometer (LC-MS/MS) and all extracts presented gallic acid and only the methanol extract obtained from the leaves exhibited hyperoside. Rutin, quercetin and chlorogenic acid were not found in the samples analysed. Total phenolic content was higher in methanol extract and total flavonoid content was low in all extracts. Antioxidant activity was evaluated by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical test, and all samples presented good to moderate antioxidant activity. These results encourage complementary studies on the chemical composition of the plant extracts focusing on isolation and structure elucidation of their active compounds.

Gunnera perpensa L. (Gunneraceae) é uma planta nativa do sul da África utilizada na medicina tradicional como antibiótico e antifúngico. Gunnera manicata L. é uma planta nativa do sul do Brasil também da família Gunneraceae e, apesar disso, não há informações sobre suas propriedades químicas e farmacológicas. Assim, o objetivo deste estudo foi avaliar o perfil fitoquímico e farmacológico dos extratos aquoso e metanólico de G. manicata. Os resultados do ensaio microbiológico de difusão em ágar demonstraram que os extratos testados foram ativos contra Staphylococcus aureus e Candida albicans. A presença de compostos fenólicos foi investigada pela técnica de Cromatografia Líquida acoplada a espectrômetro de massas em Tandem (CL-EM/EM). Em todas as amostras analisadas verificou-se a presença de ácido gálico e somente o extrato metanólico das folhas apresentou hiperosídeo. Rutina, quercetina e ácido clorogênico não foram encontrados. O conteúdo total de compostos fenólicos foi maior nos extratos metanólicos e o conteúdo de flavonóides totais foi baixo em todos os extratos. A atividade antioxidante foi avaliada pelo teste da atividade do radical 2,2-diphenyl-1-picril-hidrazil (DPPH) e todas as amostras apresentaram boa a moderada atividade antioxidante. Esses resultados encorajam estudos complementares da composição química dos extratos com foco no isolamento e na elucidação estrutural dos compostos ativos.

Associação entre artrite reumatoide e citrulinização proteica por porphyromonas gingivalis: revisão de literatura / Association between Rheumatoid Arthritis and protein citrulinization by Porphyromonas gingivalis: Literature Review

A presença de peptidil-arginina deaminase (PADs), enzimas de Porphyromonas gingivalis (P. gingivalis), encontradas em pacientes com periodontite, são capazes de quebrar a tolerância imune, mediante citrulinização proteica, culminando, em um paciente suscetível, ao desenvolvimento da artrite reumatoide (AR). O objetivo desta revisão de literatura é avaliar uma possível correlação entre a periodontite e AR por meio da citrulinização proteica realizada por P. gingivalis. Para o desenvolvimento desta revisão de literatura, foi realizada uma busca na base de dados eletrônicas PUBMED, no período de maio a agosto de 2017. Foi utilizada uma estratégia de busca otimizada com as seguintes palavraschave: rheumatoid arthritis, periodontal disease e P. gingivalis. Assim, foram encontrados um total de 83 artigos, sendo selecionados inicialmente por título e resumo por um revisor e, posteriormente, por outro revisor, selecionando pelos critérios de inclusão: artigos completos escritos em língua portuguesa, espanhola ou inglesa; ter 10 anos ou menos de publicação. Ao final da seleção foram obtidos 22 artigos; destes, 15 incluídos por serem estudos clínicos em animais ou humanos. De acordo com este estudo, foi possível correlacionar positivamente a periodontite e a AR por meio da citrulinização proteica realizada pela bactéria P. gingivalis. Contudo, a mediação por PADs não é a única e exclusiva forma de correlação entre essas doenças, sendo necessários mais estudos para estabelecer outras possíveis correlações. (AU)

The presence of peptidyl arginine deaminase (PADs), an enzyme associated to Porphyromonas gingivalis (P. gingivalis), found in patients with periodontitis, can lead to the breakdown of immune tolerance by means of protein citrulinization, leading to a development of rheumatoid arthritis (RA) in susceptible patients. The objective of this literature review is to evaluate a possible correlation between periodontitis and RA through protein citrulinization performed by P. gingivalis. For the development of this literature review, a search was performed on the electronic database PUBMED from May to August 2017. An optimized search strategy was used with the following keywords: rheumatoid arthritis, periodontal disease and P. gingivalis. A total of 83 articles were found, being initially selected by title and abstract by one reviewer and later by another reviewer selecting by inclusion criteria: Complete articles written in Portuguese, Spanish or English; have 10 years or less of publication. At the end of the selection, 22 articles were obtained; of these, 15 included by being clinical studies in animals or humans. According to this study, it is possible to positively correlate periodontitis and RA with protein citrulinization performed by P. gingivalis. However, mediation by PADs is not the only and exclusive form of correlation between these diseases, and further studies are needed to establish other possible correlations. (AU)