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1.
Salud Publica Mex ; 55(4): 416-20, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-24165718

RESUMEN

OBJECTIVE: Describe factors associated with aggressive forms of recurrent respiratory papillomatosis (RRP). MATERIALS AND METHODS: One hundred eighty-nine RRP cases diagnosed between 1985 and 2009 were identified in pathological records. HPV was detected by the SPF-10 method with broad spectrum primers, (version 1). RESULTS: 113 patients had only one surgery (less aggressive) and 76, two or more interventions (more aggressive). The likelihood of aggressive lesions decreased with increasing age at diagnosis and HPV-11 was associated with no significant increase in the risk of aggressiveness. CONCLUSIONS: The age at diagnosis was the main determinant of RRP aggressiveness.


Asunto(s)
Papillomaviridae/clasificación , Infecciones por Papillomavirus/virología , Infecciones del Sistema Respiratorio/virología , Adolescente , Adulto , Niño , Preescolar , Colombia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Adulto Joven
2.
Head Neck ; 35(2): 229-34, 2013 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-22367608

RESUMEN

BACKGROUND: Knowledge on human papillomavirus (HPV) genotype distribution in recurrent respiratory papillomatosis (RRP) is essential to assess the impact of HPV vaccine. It is provided information for Colombia. METHODS: In all, 189 RRP primary cases diagnosed between 1985 and 2009 were identified from 5 pathology laboratories of Cali and Medellin, Colombia. HPV DNA testing in 129 cases that fulfilled inclusion criteria (available paraffin blocks, amplifiable DNA, and confirmed histologic diagnosis of RRP) was performed by the SPF-10/LiPA25 assay (version 1). RESULTS: Of all cases 36.1% were juvenile (<12 years old) and a majority of adults were males (p = .09); 95% of cases were HPV positive. HPV 6, 11, and 16 contributed to 69%, 27.1%, and 7.8% of all HPV positive cases. Twelve cases (9.3%) showed multiple infections; 8 of these were HPV 6 or 11 positive. CONCLUSIONS: HPV prophylactic vaccine including HPV 6 and 11 may have a major impact against RRP.


Asunto(s)
Predisposición Genética a la Enfermedad/epidemiología , Papillomavirus Humano 11/aislamiento & purificación , Papillomavirus Humano 6/aislamiento & purificación , Infecciones por Papillomavirus/epidemiología , Infecciones por Papillomavirus/genética , Infecciones del Sistema Respiratorio/epidemiología , Infecciones del Sistema Respiratorio/genética , Adolescente , Adulto , Distribución por Edad , Niño , Preescolar , Estudios de Cohortes , Colombia/epidemiología , ADN Viral/análisis , Femenino , Genotipo , Papillomavirus Humano 11/genética , Papillomavirus Humano 6/genética , Humanos , Masculino , Persona de Mediana Edad , Infecciones por Papillomavirus/diagnóstico , Infecciones por Papillomavirus/fisiopatología , Vacunas contra Papillomavirus/administración & dosificación , Vacunas contra Papillomavirus/genética , Reacción en Cadena de la Polimerasa/métodos , Prevalencia , Infecciones del Sistema Respiratorio/diagnóstico , Infecciones del Sistema Respiratorio/fisiopatología , Estudios Retrospectivos , Medición de Riesgo , Índice de Severidad de la Enfermedad , Distribución por Sexo , Población Urbana
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