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Acute myeloid leukemia (AML) is a phenotypically and genetically heterogeneous hematologic malignancy. Extensive sequencing efforts have mapped the genomic landscape of adult and pediatric AML revealing a number of biologically and prognostically relevant driver lesions. Beyond identifying recurrent genetic aberrations, it is of critical importance to fully delineate the complex mechanisms by which they contribute to the initiation and evolution of disease to ultimately facilitate the development of targeted therapies. Towards these aims, murine models of AML are indispensable research tools. The rapid evolution of genetic engineering techniques over the past 20 years has greatly advanced the use of murine models to mirror specific genetic subtypes of human AML, define cell-intrinsic and extrinsic disease mechanisms, study the interaction between co-occurring genetic lesions, and test novel therapeutic approaches. This review summarizes the mouse model systems that have been developed to recapitulate the most common genomic subtypes of AML. We will discuss the strengths and weaknesses of varying modeling strategies, highlight major discoveries emanating from these model systems, and outline future opportunities to leverage emerging technologies for mechanistic and preclinical investigations.
RESUMEN
[This corrects the article DOI: 10.3389/fonc.2022.854973.].
RESUMEN
This article reports briefly on the first UK prevalence study (undertaken in 2006-7) of the abuse and neglect of older people living in the community. Older people living in the community who reported mistreatment and neglect (2.6 per cent) equate to about 227,000 of the population aged 66 years and over. If figures are broadened to include neighbours and acquaintances, prevalence increases from 2.6 per cent to 4.0 per cent. This article identifies risk factors of loneliness, depression and poor quality of life. It suggests that nurses have a key role in day-to-day clinical practice in enabling older people to report abuse and neglect.