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Bioorg Med Chem Lett
; 20(7): 2099-102, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20223662
RESUMEN
Novel 3-aminopyrrolidine derivatives were synthesized and evaluated for their antagonistic activity against human chemokine receptor 2. Structure-activity studies on 3-aminopyrrolidine incorporating heteroatomic carbocycle moieties led to piperidine compound 19, and piperazine compounds 42, 47 and 49 as highly potent hCCR2 antagonists.