Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Más filtros

Banco de datos
Tipo de estudio
País/Región como asunto
Tipo del documento
Asunto de la revista
País de afiliación
Intervalo de año de publicación
1.
Cell ; 180(6): 1081-1097.e24, 2020 03 19.
Artículo en Inglés | MEDLINE | ID: mdl-32142650

RESUMEN

Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell subset emerges after chemotherapy. Using three immunocompetent mouse models, we recapitulated the subset switch of human tumor-infiltrating B cells during chemotherapy. By employing B-cell-specific deletion mice, we showed that ICOSL in B cells boosts anti-tumor immunity by enhancing the effector to regulatory T cell ratio. The signature of ICOSL+ B cells is imprinted by complement-CR2 signaling, which is triggered by immunogenic cell death. Moreover, we identified that CD55, a complement inhibitory protein, determines the opposite roles of B cells in chemotherapy. Collectively, we demonstrated a critical role of the B cell subset switch in chemotherapy response, which has implications in designing novel anti-cancer therapies. VIDEO ABSTRACT.


Asunto(s)
Linfocitos B/inmunología , Neoplasias de la Mama/inmunología , Ligando Coestimulador de Linfocitos T Inducibles/metabolismo , Animales , Antineoplásicos/metabolismo , Linfocitos B/metabolismo , Antígenos CD55/inmunología , Antígenos CD55/metabolismo , Línea Celular Tumoral , Proteínas del Sistema Complemento/metabolismo , Modelos Animales de Enfermedad , Femenino , Humanos , Ligando Coestimulador de Linfocitos T Inducibles/inmunología , Linfocitos Infiltrantes de Tumor/inmunología , Ratones , Ratones Endogámicos C57BL , Receptores de Complemento 3d/inmunología , Receptores de Complemento 3d/metabolismo , Transducción de Señal/inmunología , Linfocitos T Reguladores/inmunología
2.
PLoS One ; 19(9): e0309916, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39236012

RESUMEN

The green economy has been advocated globally as a solution to environmental issues. In China, it is considered a national strategy for future economic development. This study utilizes methods such as Industry Network, Maximum Spanning Tree (MST) method, Leiden Community Clustering (LCC) algorithm, and Weaver-Thomas (WT) model to explore the contribution and position of the green economy and industries in China's economic development. The findings are as follows: (1) The density of China's green industry network has experienced a process of initially tightening and then loosening, ultimately tending towards stability. (2) The trunk structure of China's industrial network remains relatively stable, forming an industrial structure with electricity, heat production and supply as the core. (3) China's industrial and green industry communities continue to improve and become more cohesive, but some green industries are still on the periphery of communities. (4) The ability of green industries to pull other industries is weak, and the subsequent promotion momentum needs to be improved. However, the green industry still has enormous room for growth and potential to unleash its long-term positive multiplier effects. More attention and support need to be given by managers and decision-makers, so that it can make better contributions to society and the economy.


Asunto(s)
Desarrollo Económico , Industrias , China , Industrias/economía , Algoritmos , Modelos Económicos , Humanos , Conservación de los Recursos Naturales/métodos , Conservación de los Recursos Naturales/economía
3.
Nat Cancer ; 3(4): 453-470, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35484420

RESUMEN

Phagocytosis is required for the optimal efficacy of many approved and promising therapeutic antibodies for various malignancies. However, the factors that determine the response to therapies that rely on phagocytosis remain largely elusive. Here, we demonstrate that mitochondrial fission in macrophages induced by multiple antibodies is essential for phagocytosis of live tumor cells. Tumor cells resistant to phagocytosis inhibit mitochondrial fission of macrophages by overexpressing glutamine-fructose-6-phosphate transaminase 2 (GFPT2), which can be targeted to improve antibody efficacy. Mechanistically, increased cytosolic calcium by mitochondrial fission abrogates the phase transition of the Wiskott-Aldrich syndrome protein (WASP)-Wiskott-Aldrich syndrome interacting protein (WIP) complex and enables protein kinase C-θ (PKC-θ) to phosphorylate WIP during phagocytosis. GFPT2-mediated excessive use of glutamine by tumor cells impairs mitochondrial fission and prevents access of PKC-θ to compartmentalized WIP in macrophages. Our data suggest that mitochondrial dynamics dictate the phase transition of the phagocytic machinery and identify GFPT2 as a potential target to improve antibody therapy.


Asunto(s)
Citofagocitosis , Neoplasias , Proteínas del Citoesqueleto/metabolismo , Glutamina/farmacología , Humanos , Macrófagos , Dinámicas Mitocondriales , Neoplasias/tratamiento farmacológico , Fagocitosis , Proteína Quinasa C-theta/metabolismo , Proteína del Síndrome de Wiskott-Aldrich/metabolismo
4.
Adv Sci (Weinh) ; 8(19): e2101848, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34363355

RESUMEN

Carcinoma-associated fibroblasts (CAFs) consist of heterogeneous subpopulations that play a critical role in the dynamics of the tumor microenvironment. The extracellular signals of CAFs have been attributed to the extracellular matrix, cytokines, cell surface checkpoints, and exosomes. In the present study, it is demonstrated that the CD10 transmembrane hydrolase expressed on a subset of CAFs supports tumor stemness and induces chemoresistance. Mechanistically, CD10 degenerates an antitumoral peptide termed osteogenic growth peptide (OGP). OGP restrains the expression of rate-limiting desaturase SCD1 and inhibits lipid desaturation, which is required for cancer stem cells (CSCs). Targeting CD10 significantly improves the efficacy of chemotherapy in vivo. Clinically, CD10-OGP signals are associated with the response to neoadjuvant chemotherapy in patients with breast cancer. The collective data suggest that a nexus between the niche and lipid metabolism in CSCs is a promising therapeutic target for breast cancer.


Asunto(s)
Neoplasias de la Mama/metabolismo , Fibroblastos Asociados al Cáncer/metabolismo , Histonas/metabolismo , Péptidos y Proteínas de Señalización Intercelular/metabolismo , Metabolismo de los Lípidos/genética , Células Madre Neoplásicas/metabolismo , Neprilisina/metabolismo , Estearoil-CoA Desaturasa/metabolismo , Neoplasias de la Mama/genética , China , Femenino , Histonas/genética , Humanos , Péptidos y Proteínas de Señalización Intercelular/genética , Neprilisina/genética , Transducción de Señal/genética , Estearoil-CoA Desaturasa/genética , Microambiente Tumoral/genética
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA