Detecting an infiltrated intravenous catheter using indigo carmine: a novel method.

An extravasated IV catheter may have serious clinical consequences. These include the inability to circulate emergency medications, cause pain on injection, infection at the site, and tissue damage. Clinical signs such as swelling, redness, and pain with injection are valuable, but may not be helpful in the presence of obesity, edema, or in a tracheally intubated and sedated patient. Here we describe a case illustrating a novel approach in which we used an IV dye injection (indigo carmine) to detect a correctly placed and then an extravasated IV. The ability to see visible flow of IV dye intravascularly helped confirm the correct placement. The technique we describe is quick, safe, and inexpensive.

Use of a modifier reduces inconsistency in the American Society of Anesthesiologists Physical Status Classification in parturients.

In this study, we sought to determine whether there is a significant discrepancy among a group of practitioners when rating pregnant patients using the ASA Physical Status Classification and whether this discrepancy could be resolved with the addition of a modifier for pregnancy. Our results indicate that significant discrepancy occurs and that it is reduced with the use of the modifier, especially when referring to the healthy parturient.

A novel standard to evaluate the impact of therapeutic agents on patient safety - The BURDEN OF THERAPY™©∗.

PURPOSE: Currently, treatment-emergent adverse events (TEAEs) during a clinical study are summarized over the entire study period. OBJECTIVE: Develop and validate a novel methodology, BURDEN OF THERAPY©∗ (BOTh©∗), to quantify presence and severity of TEAEs on each day of study. METHODS: BOTh utilizes patient-level safety data to derive a quantitative estimate for the burden of TEAEs that all or individual patients experience on each day of a clinical study. Burden estimate for each day is based on number and severity of TEAEs. A chart displays the total burden experienced by patients on each day throughout the study and statistical analyses may be performed with the area under curve. Methodology was applied to two validated and published clinical studies and statistically analyzed. RESULTS: In a peripheral neuropathic pain study, the topical group had a greater incidence of TEAEs than the oral anticonvulsant group when evaluated using current methodology. Utilizing BOTh, TEAEs with the topical agent were of short duration and occurred for three days after application, whereas TEAEs with the oral agent increased during dose titration and persisted to study end. In an overactive bladder study there was a minimal difference in overall TEAEs between groups, but BOTh revealed a higher burden related to dry mouth in the antimuscarinic versus ß3 adrenergic agonist group. CONCLUSIONS: BOTh is a highly sensitive method to evaluate the comparative burden experienced by patients during treatment, and can facilitate better informed treatment selection. We propose BOTh as the new standard for analyzing safety during clinical studies.

Importance of patient selection for patient-controlled epidural analgesia (PCEA), as even low-concentration solutions may lead to a very high block.

Patient-controlled epidural analgesia (PCEA) is an excellent choice of analgesia technique in labor; however, patient selection for such treatment is important. A 14 year old healthy parturient receiving PCEA had a very high block due to patient noncompliance.

Successful implementation of a family and patient activated rapid response team in an adult level 1 trauma center.

BACKGROUND: When cardiac arrests occur in hospitalized patients, delays in treatment are associated with lower survival and poorer outcomes. Patients often show a physiological deterioration hours before cardiac or pulmonary arrest. As a result, many hospitals have implemented a rapid response team (RRT) as part of their involvement in the 100,000 Lives Campaign sponsored by the Institute for Healthcare Improvement. METHOD: In conjunction with the University Health System Consortium (UHC) Patient- and Family-Centered Care Implementation Collaborative, Shands Jacksonville Medical Center (SJMC) launched a pilot RRT program in October 2006 followed by campus-wide implementation in July 2007. The program was enhanced to allow patient and family activation of the RRT in October 2007. RESULTS: A review of the first 2 years of data indicates that the SJMC RRT received 25 patient or family activated calls. Forty-eight percent of the calls were initiated by a family member and 52% by the actual patient. Reasons for the calls have varied but the most frequent reason identified by the patient or family member was "something just doesn't feel right" with the patient. Other leading reasons for calls were similar to criteria that are used by staff-initiated calls, such as shortness of breath and pain issues. CONCLUSION: This is one of the first initiations of a family activated component of the RRT in an adult hospital that has led to improvements in outcomes such as reduction in mortality rates and non-ICU codes, without an overload of false positive calls.

Local anesthetic requirements are greater in dystocia than in normal labor.

BACKGROUND: Dystocia is characterized by abnormal progress of labor and is a common contemporary indication for cesarean delivery in the United States. There has been considerable controversy as to whether epidural analgesia causes dysfunctional labor leading to cesarean delivery for dystocia. The minimum local analgesic concentration (MLAC) is a clinical model used to determine the relative potencies of local anesthetics in the first stage of labor. In this article, the authors report a prospective study determining the MLAC of bupivacaine in early labor of parturients who eventually delivered either vaginally or via cesarean section. METHODS: An up-down sequential allocation technique was used to determine the MLAC of bupivacaine in 57 nulliparous parturients assigned to either vaginal delivery or cesarean section arms. In addition, patients were assigned to groups receiving or not receiving intravenous oxytocin at the time of epidural placement. Only patients who delivered by the assigned delivery mode were included in the MLAC analyses. RESULTS: Parturients who later delivered vaginally had 25% and 31% lower MLAC values (0.078% and 0.085% wt/vol bupivacaine, receiving or not receiving intravenous oxytocin, respectively) than those who later delivered by cesarean section (0.102% and 0.106% wt/vol bupivacaine, receiving or not receiving intravenous oxytocin, respectively). CONCLUSIONS: These data suggest that an increased local anesthetic requirement for epidural labor analgesia is associated with more intense pain related to dystocia. Women in early, clinically normal labor but who later develop dystocia require more local anesthetic and, by inference, are experiencing more severe pain than women who deliver vaginally. This association should be considered when studying the relation between the method of labor analgesia and the course of labor.

Scavenging in the operating room.

PURPOSE OF REVIEW: The use of inhalation general anesthetic gases has led to contamination of the operating room environment. Chronic exposure to these agents has been associated with a number of adverse health effects. Controversy remains with regard to these health effects, and whether further reducing the level of operating room contamination should be a high priority. Current methods are outlined by which anesthetic waste gases contaminate and are removed from the operating room. These controversies are explored in the light of recent research. RECENT FINDINGS: Recent work employing genotoxicity studies suggests that National Institute for Occupational Safety and Health recommendations may be appropriate to protect healthcare workers. New developments over the past year include the suggestion of employing devices such as the Anesthetic Scavenging Hood (ASH), SiBI tube connector and mask stopper. The use of these devices, in concert with efficient anesthesia machine scavenging, may further reduce operating room contamination. SUMMARY: The National Institute for Occupational Safety and Health calls for lower levels of exposure when compared with those found in European standards. It may be appropriate for European guidelines to be re-addressed; however, more conclusive studies need to be undertaken to identify the precise effects of these agents at a given exposure level. It may also be appropriate to expand the arena of monitoring and scavenging to all areas where inhalation anesthetics are used or emitted, such as in the post-anesthesia care unit and research laboratory settings.

The use of a uniquely designed anesthetic scavenging hood to reduce operating room anesthetic gas contamination during general anesthesia.

UNLABELLED: Numerous studies have suggested that chronic exposure to trace levels of anesthetic gas is harmful to operating room (OR) personnel. In the delivery of pediatric general anesthesia, an uncuffed endotracheal tube (ETT) is normally used which can result in considerable volatile anesthetic and nitrous oxide contamination of the OR. In this report, we present a method to reduce exposure to these anesthetic gases by means of an anesthetic scavenging hood (ASH). The ASH was used on six pediatric patients undergoing general endotracheal anesthesia via an uncuffed ETT. Measurements of all ambient gas levels were made 6 in. horizontally from the patient's ear and 6 in. from the table surface. The application of the vacuum source to the ASH resulted in a very significant (P < 0.01, paired t-test) decrease in levels of ambient anesthetic gas, with no measurable change in ventilatory variables or changes in body temperature (P > 0.05, paired t-test). Discontinuation of the vacuum force to the ASH resulted in a marked increase in ambient levels of anesthetic gas. We conclude that the ASH is extremely effective in reducing waste anesthetic gas associated with anesthesia administered via an uncuffed ETT. The ASH may be a valuable and cost-effective addition in the OR for both reducing ambient anesthetic waste gas levels and conserving patient heat. IMPLICATIONS: Chronic exposure to trace levels of anesthetic gas is harmful to operating room personnel, especially in the delivery of pediatric general anesthesia via an uncuffed endotracheal tube. The anesthetic scavenging hood is a cost-effective and efficient method to reduce these waste anesthetic gases, and it offers patient heat conservation.

Hyperbaric therapy for a postpartum patient with prolonged epidural blockade and tomographic evidence of epidural air.

UNLABELLED: We used the epidural technique "loss of resistance to air" to provide labor analgesia in a healthy parturient. Inadequate analgesia required epidural catheter replacement using the same technique. Delayed recovery of sensory and motor blockade postpartum necessitated computed tomography and magnetic resonance imaging studies. These revealed 4-6 mL of air in the epidural space with no evidence of thecal compression. On the advice of the neurologist, this patient underwent hyperbaric therapy 14 h after the discontinuation of the epidural infusion. The patient made a complete recovery and was discharged without neurologic sequelae. It is possible that epidural air delayed the absorption of local anesthetics as a result of a reduction in the vascular surface area. Although a cause and effect relationship between epidural air and prolonged neurological block cannot be categorically established, the use of "loss of resistance to air" technique complicated the differential diagnosis. IMPLICATIONS: We report a case of prolonged motor and sensory block after labor analgesia using "loss of resistance to air" technique. The presence of epidural air on tomography resulted in the patient undergoing hyperbaric therapy. The use of loss of resistance to air technique complicated the differential diagnosis of prolonged sensory and motor block.

A novel ambulatory intravenous holder: preliminary findings.

IMPLICATIONS: Many devices serve as portable systems for IV equipment but are expensive and use complex electronic controls. We present a novel device to facilitate safe ambulation of IV-dependent patients. This device was effective in delivering required therapeutic flow rates over time periods desired for unattended operation.