Extragastrointestinal stromal tumor in the rectovaginal septum in an adolescent.

•We report a rare case of EGIST in rectovaginal septrum.•Adolescent patient who died due to an aggressive EGIST•Infrequent type of pelvic EGIST and literature review.

Gastrointestinal stromal tumors as an incidental finding in patients with a presumptive diagnosis of ovarian cancer.

OBJECTIVE: To report the clinical presentation and oncologic outcomes of a series of patients who presented with an abdominal or pelvic mass and were diagnosed with a gastrointestinal stromal tumor (GIST). METHODS: Data were obtained on all patients who presented with an abdominal or pelvic mass between September 2007 and June 2010 and who were ultimately diagnosed with a GIST. The patients' medical records were reviewed. A literature review was also conducted. RESULTS: Six patients were identified who met the inclusion criteria. All six patients had a tumor in the intestinal tract arising from the small bowel. The mean tumor size was 12 cm (range, 6 to 22 cm). A complete resection was achieved in five of the six patients. There were no intraoperative complications; one patient had a postoperative complication. Two patients were treated with imatinib after surgery. The mean follow-up time was 32 months (range, 0.3 to 40 months). At the last follow-up, five of the six patients were without any evidence of disease. One patient died of an unrelated hepatic encephalopathy. The incidence in our institution is 3%. CONCLUSION: GISTs are uncommon; however, they should be considered in the differential diagnosis of patients presenting with an abdominal or pelvic mass.

Virus del papiloma humano, respuesta inmune y cáncer cervical: una relación compleja / Human papillomavirus, immune response and cervical cancer: a complex relationship

El cáncer de cuello uterino se considera como un grave problema de salud pública con una alta incidencia en los países en desarrollo. La infección, permanencia y replicación del virus de papiloma humano (HPV, por sus siglas en inglés) de alto riesgo a nivel cervical están relacionadas con el desarrollo del cáncer de cuello uterino. En condiciones normales, el sistema inmune es capaz de controlar y eliminar la infección por acción de la inmunidad innata, la activación de una respuesta tipo celular y la creación de anticuerpos dirigidos principalmente a las proteínas de la cápside del virión (L1 y L2). A pesar de toda la maquinaria de protección inmune del hospedero, el virus posee estrategias de evasión, conservando un número reducido de copias en las células basales proliferantes y aprovechando la corta vida natural del queratinocito. En esta revisión se tratarán los diferentes mecanismos inmunológicos del hospedero en la respuesta a la infección por el HPV.