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1.

Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis.

Liao, Yi-En; Xu, Yongmei; Arnold, Katelyn; Zhang, Fuming; Li, Jine; Sellers, Rani; Yin, Chaoyin; Pagadala, Vijayakanth; Inman, Anna Marie; Linhardt, Robert J; Xu, Ding; Pawlinski, Rafal; Liu, Jian.

Proc Natl Acad Sci U S A ; 120(4): e2209528120, 2023 01 24.

Artículo en Inglés | MEDLINE | ID: mdl-36649428

2.

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.

Sparkenbaugh, Erica M; Henderson, Michael W; Miller-Awe, Megan; Abrams, Christina; Ilich, Anton; Trebak, Fatima; Ramadas, Nirupama; Vital, Shantel; Bohinc, Dillon; Bane, Kara L; Chen, Chunsheng; Patel, Margi; Wallisch, Michael; Renné, Thomas; Gruber, Andras; Cooley, Brian; Gailani, David; Kasztan, Malgorzata; Vercellotti, Gregory M; Belcher, John D; Gavins, Felicity E; Stavrou, Evi X; Key, Nigel S; Pawlinski, Rafal.

Blood ; 141(15): 1871-1883, 2023 04 13.

Artículo en Inglés | MEDLINE | ID: mdl-36706361

3.

Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation.

Prasad, Joni M; Negrón, Oscar; Du, Xinli; Mullins, Eric S; Palumbo, Joseph S; Gilbertie, Jessica M; Höök, Magnus; Grover, Steven P; Pawlinski, Rafal; Mackman, Nigel; Degen, Jay L; Flick, Matthew J.

Proc Natl Acad Sci U S A ; 118(1)2021 01 05.

Artículo en Inglés | MEDLINE | ID: mdl-33443167

4.

Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease.

Ansari, Junaid; Senchenkova, Elena Y; Vital, Shantel A; Al-Yafeai, Zaki; Kaur, Gaganpreet; Sparkenbaugh, Erica M; Orr, A Wayne; Pawlinski, Rafal; Hebbel, Robert P; Granger, D Neil; Kubes, Paul; Gavins, Felicity N E.

Blood ; 137(11): 1538-1549, 2021 03 18.

Artículo en Inglés | MEDLINE | ID: mdl-33512489

5.

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.

Henderson, Michael W; Sparkenbaugh, Erica M; Wang, Shaobin; Ilich, Anton; Noubouossie, Denis F; Mailer, Reiner; Renné, Thomas; Flick, Matthew J; Luyendyk, James P; Chen, Zu-Lin; Strickland, Sidney; Stravitz, R Todd; McCrae, Keith R; Key, Nigel S; Pawlinski, Rafal.

Blood ; 138(3): 259-272, 2021 07 22.

Artículo en Inglés | MEDLINE | ID: mdl-33827130

6.

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways.

Noubouossie, Denis F; Henderson, Michael W; Mooberry, Micah; Ilich, Anton; Ellsworth, Patrick; Piegore, Mark; Skinner, Sarah C; Pawlinski, Rafal; Welsby, Ian; Renné, Thomas; Hoffman, Maureane; Monroe, Dougald M; Key, Nigel S.

Blood ; 135(10): 755-765, 2020 03 05.

Artículo en Inglés | MEDLINE | ID: mdl-31971571

7.

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease.

Sparkenbaugh, Erica M; Chen, Chunsheng; Brzoska, Tomasz; Nguyen, Julia; Wang, Shaobin; Vercellotti, Gregory M; Key, Nigel S; Sundd, Prithu; Belcher, John D; Pawlinski, Rafal.

Blood ; 135(20): 1783-1787, 2020 05 14.

Artículo en Inglés | MEDLINE | ID: mdl-31977004

8.

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease.

Faes, Camille; Ilich, Anton; Sotiaux, Amandine; Sparkenbaugh, Erica M; Henderson, Michael W; Buczek, Laura; Beckman, Joan D; Ellsworth, Patrick; Noubouossie, Denis F; Bhoopat, Lantarima; Piegore, Mark; Renoux, Céline; Bergmeier, Wolfgang; Park, Yara; Ataga, Kenneth I; Cooley, Brian; Wolberg, Alisa S; Key, Nigel S; Pawlinski, Rafal.

Blood ; 133(23): 2529-2541, 2019 06 06.

Artículo en Inglés | MEDLINE | ID: mdl-30952675

9.

A pilot study of the effect of rivaroxaban in sickle cell anemia.

Ataga, Kenneth I; Elsherif, Laila; Wichlan, David; Wogu, Adane F; Matsui, Neil; Pawlinski, Rafal; Cai, Jianwen; Key, Nigel S.

Transfusion ; 61(6): 1694-1698, 2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-33660875

10.

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.

Senchenkova, Elena Y; Ansari, Junaid; Becker, Felix; Vital, Shantel A; Al-Yafeai, Zaki; Sparkenbaugh, Erica M; Pawlinski, Rafal; Stokes, Karen Y; Carroll, Jennifer L; Dragoi, Ana-Maria; Qin, Cheng Xue; Ritchie, Rebecca H; Sun, Hai; Cuellar-Saenz, Hugo H; Rubinstein, Mara R; Han, Yiping W; Orr, A Wayne; Perretti, Mauro; Granger, D Neil; Gavins, Felicity N E.

Circulation ; 140(4): 319-335, 2019 07 23.

Artículo en Inglés | MEDLINE | ID: mdl-31154815

11.

In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps.

Noubouossie, Denis F; Whelihan, Matthew F; Yu, Yuan-Bin; Sparkenbaugh, Erica; Pawlinski, Rafal; Monroe, Dougald M; Key, Nigel S.

Blood ; 129(8): 1021-1029, 2017 02 23.

Artículo en Inglés | MEDLINE | ID: mdl-27919911

12.

Elevated hematocrit enhances platelet accumulation following vascular injury.

Walton, Bethany L; Lehmann, Marcus; Skorczewski, Tyler; Holle, Lori A; Beckman, Joan D; Cribb, Jeremy A; Mooberry, Micah J; Wufsus, Adam R; Cooley, Brian C; Homeister, Jonathan W; Pawlinski, Rafal; Falvo, Michael R; Key, Nigel S; Fogelson, Aaron L; Neeves, Keith B; Wolberg, Alisa S.

Blood ; 129(18): 2537-2546, 2017 05 04.

Artículo en Inglés | MEDLINE | ID: mdl-28251913

13.

Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity.

Antoniak, Silvio; Tatsumi, Kohei; Schmedes, Clare M; Grover, Steven P; Pawlinski, Rafal; Mackman, Nigel.

J Mol Cell Cardiol ; 122: 80-87, 2018 09.

Artículo en Inglés | MEDLINE | ID: mdl-30098988

14.

It's "PT" for SCD!

Pawlinski, Rafal.

Blood ; 126(15): 1739-40, 2015 Oct 08.

Artículo en Inglés | MEDLINE | ID: mdl-26450955

15.

Tissue factor activity is increased in neutrophils from JAK2 V617F-mutated essential thrombocythemia and polycythemia vera patients.

Reeves, Brandi N; Kim, Soo Jin; Song, Jihyun; Wilson, Kathryn J; Henderson, Michael W; Key, Nigel S; Pawlinski, Rafal; Prchal, Josef T.

Am J Hematol ; 97(2): E37-E40, 2022 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-34748652

16.

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade.

Solovey, Anna; Somani, Arif; Belcher, John D; Milbauer, Liming; Vincent, Lucile; Pawlinski, Rafal; Nath, Karl A; Kelm, Robert J; Mackman, Nigel; O'Sullivan, M Gerard; Gupta, Kalpna; Vercellotti, Gregory M; Hebbel, Robert P.

Am J Hematol ; 92(11): 1119-1130, 2017 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-28699284

17.

Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.

Antoniak, Silvio; Cardenas, Jessica C; Buczek, Laura J; Church, Frank C; Mackman, Nigel; Pawlinski, Rafal.

Cardiology ; 136(4): 258-268, 2017.

Artículo en Inglés | MEDLINE | ID: mdl-27880950

18.

Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations.

Magnus, Nathalie; Garnier, Delphine; Meehan, Brian; McGraw, Serge; Lee, Tae Hoon; Caron, Maxime; Bourque, Guillaume; Milsom, Chloe; Jabado, Nada; Trasler, Jacquetta; Pawlinski, Rafal; Mackman, Nigel; Rak, Janusz.

Proc Natl Acad Sci U S A ; 111(9): 3544-9, 2014 Mar 04.

Artículo en Inglés | MEDLINE | ID: mdl-24520174

19.

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury.

Rautou, Pierre-Emmanuel; Tatsumi, Kohei; Antoniak, Silvio; Owens, A Phillip; Sparkenbaugh, Erica; Holle, Lori A; Wolberg, Alisa S; Kopec, Anna K; Pawlinski, Rafal; Luyendyk, James P; Mackman, Nigel.

J Hepatol ; 64(1): 53-9, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26325534

20.

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.

Sparkenbaugh, Erica M; Chantrathammachart, Pichika; Mickelson, Jacqueline; van Ryn, Joanne; Hebbel, Robert P; Monroe, Dougald M; Mackman, Nigel; Key, Nigel S; Pawlinski, Rafal.

Blood ; 123(11): 1747-56, 2014 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-24449213

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