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1.
Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
Mol Syst Biol
; 20(4): 374-402, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38459198
2.
Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds.
Drug Metab Dispos
; 52(6): 539-547, 2024 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38604730
3.
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model.
Xenobiotica
; 52(7): 661-668, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-36190773
4.
Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
Drug Metab Dispos
; 49(8): 668-678, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34035124
5.
Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery.
Xenobiotica
; 50(3): 270-279, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31215316
6.
Sensitization to storage proteins in peanut and hazelnut is associated with higher levels of inflammatory markers in asthma.
Clin Mol Allergy
; 18: 11, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32581655
7.
Determination of low intrinsic clearance in vitro: the benefit of a novel internal standard in human hepatocyte incubations.
Xenobiotica
; 49(4): 381-387, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29521135
8.
Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set.
Xenobiotica
; 47(9): 741-751, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-27560606
9.
Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.
Clin Mol Allergy
; 15: 4, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28270741
10.
A comparative evaluation of models to predict human intestinal metabolism from nonclinical data.
Biopharm Drug Dispos
; 38(3): 163-186, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28152562
11.
Metabolic profiling of TRPV1 antagonists of the benzothiazole amide series: implications for in vitro genotoxicity assessment.
Xenobiotica
; 43(2): 201-10, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22867274
12.
Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction.
Biochem Pharmacol
; 215: 115755, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37607620
13.
Identification of M4205âA Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.
J Med Chem
; 66(4): 2386-2395, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36728508
14.
The right compound in the right assay at the right time: an integrated discovery DMPK strategy.
Drug Metab Rev
; 44(3): 224-52, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22697420
15.
Novel bioactivation mechanism of reactive metabolite formation from phenyl methyl-isoxazoles.
Drug Metab Dispos
; 40(11): 2185-91, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22908203
16.
A pragmatic approach using first-principle methods to address site of metabolism with implications for reactive metabolite formation.
J Chem Inf Model
; 52(3): 686-95, 2012 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22299574
17.
Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds.
AAPS J
; 24(2): 41, 2022 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35277751
18.
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
AAPS J
; 24(5): 85, 2022 07 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35854202
19.
Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.
J Med Chem
; 64(16): 11904-11933, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34382802
20.
Accuracy of a point-of-care testing device in children with suspected respiratory allergy.
Allergy Asthma Proc
; 31(2): e11-7, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20236576