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1.
Public Health Nutr ; 17(9): 1949-59, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23883550

RESUMEN

OBJECTIVE: Fish consumption influences a number of health outcomes. Few studies have directly compared dietary assessment methods to determine the best approach to estimating intakes of fish and its component nutrients, including DHA, and toxicants, including methylmercury. Our objective was to compare three methods of assessing fish intake. DESIGN: We assessed 30 d fish intake using three approaches: (i) a single question on total fish consumption; (ii) a brief comprehensive FFQ that included four questions about fish; and (iii) a focused FFQ with thirty-six questions about different finfish and shellfish. SETTING: Obstetrics practices in Boston, MA, USA. SUBJECTS: Fifty-nine pregnant women who consumed ≤2 monthly fish servings. RESULTS: Estimated intakes of fish, DHA and Hg were lowest with the one-question screener and highest with the thirty-six-item fish questionnaire. Estimated intake of DHA with the thirty-six-item questionnaire was 4·4-fold higher (97 v. 22 mg/d), and intake of Hg was 3·8-fold higher (1·6 v. 0·42 µg/d), compared with the one-question screener. Plasma DHA concentration was correlated with fish intake assessed with the one-question screener (Spearman r = 0·27, P = 0·04), but not with the four-item FFQ (r = 0·08, P = 0·54) or the thirty-six-item fish questionnaire (r = 0·01, P = 0·93). In contrast, blood and hair Hg concentrations were similarly correlated with fish and Hg intakes regardless of the assessment method (r = 0·35 to 0·52). CONCLUSIONS: A longer questionnaire provides no advantage over shorter questionnaires in ranking intakes of fish, DHA and Hg compared with biomarkers, but estimates of absolute intakes can vary by as much as fourfold across methods.


Asunto(s)
Encuestas sobre Dietas/métodos , Dieta , Peces , Fenómenos Fisiologicos Nutricionales Maternos , Alimentos Marinos , Mariscos , Adulto , Animales , Biomarcadores/análisis , Biomarcadores/sangre , Boston , Estudios Transversales , Dieta/efectos adversos , Ácidos Grasos Omega-3/sangre , Femenino , Estudios de Seguimiento , Cabello/química , Humanos , Mercurio/análisis , Mercurio/sangre , Evaluación Nutricional , Proyectos Piloto , Embarazo , Reproducibilidad de los Resultados , Encuestas y Cuestionarios , Factores de Tiempo
2.
Nutr J ; 12: 33, 2013 Mar 15.
Artículo en Inglés | MEDLINE | ID: mdl-23496848

RESUMEN

BACKGROUND: Nutritionists advise pregnant women to eat fish to obtain adequate docosahexaenoic acid (DHA), an essential nutrient important for optimal brain development. However, concern exists that this advice will lead to excess intake of methylmercury, a developmental neurotoxicant. OBJECTIVE: Conduct a pilot intervention to increase consumption of high-DHA, low-mercury fish in pregnancy. METHODS: In April-October 2010 we recruited 61 women in the greater Boston, MA area at 12-22 weeks gestation who consumed <=2 fish servings/month, and obtained outcome data from 55. We randomized participants to 3 arms: Advice to consume low-mercury/high-DHA fish (n=18); Advice + grocery store gift cards (GC) to purchase fish (n=17); or Control messages (n=20). At baseline and 12-week follow-up we estimated intake of fish, DHA and mercury using a 1-month fish intake food frequency questionnaire, and measured plasma DHA and blood and hair total mercury. RESULTS: Baseline characteristics and mean (range) intakes of fish [21 (0-125) g/day] and DHA from fish [91 (0-554) mg/d] were similar in all 3 arms. From baseline to follow-up, intake of fish [Advice: 12 g/day (95% CI: -5, 29), Advice+GC: 22 g/day (5, 39)] and DHA [Advice: 70 mg/d (3, 137), Advice+GC: 161 mg/d (93, 229)] increased in both intervention groups, compared with controls. At follow-up, no control women consumed >= 200mg/d of DHA from fish, compared with 33% in the Advice arm (p=0.005) and 53% in the Advice+GC arm (p=0.0002). We did not detect any differences in mercury intake or in biomarker levels of mercury and DHA between groups. CONCLUSIONS: An educational intervention increased consumption of fish and DHA but not mercury. Future studies are needed to determine intervention effects on pregnancy and childhood health outcomes. TRIAL REGISTRATION: Registered on clinicaltrials.gov as NCT01126762.


Asunto(s)
Ácidos Docosahexaenoicos/sangre , Peces , Compuestos de Metilmercurio/sangre , Adulto , Animales , Biomarcadores/sangre , Boston , Ácidos Docosahexaenoicos/administración & dosificación , Femenino , Estudios de Seguimiento , Contaminación de Alimentos/análisis , Humanos , Compuestos de Metilmercurio/administración & dosificación , Proyectos Piloto , Embarazo , Resultado del Embarazo , Factores Socioeconómicos , Encuestas y Cuestionarios
3.
Matern Child Health J ; 15(7): 1119-26, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20711804

RESUMEN

The goal of this paper was to determine predictors of having a weight gain goal in early pregnancy. In 2008, we administered a 48-item survey to 249 pregnant women attending obstetric visits. We examined predictors of women having a goal concordant or discordant with 1990 Institute of Medicine (IOM) guidelines, vs. no goal, using binary and multinomial logistic regression. Of the 292 respondents, 116 (40%) had no gestational weight gain goal, 112 (39%) had a concordant goal and 61 (21%) had a goal discordant with IOM guidelines. Predictors of a guideline-concordant goal, vs. no goal, included sugar sweetened beverage consumption < vs. ≥ 1 serving per week (OR = 2.4, 95%CI: 1.1, 5.7), physical activity ≥ vs. <2.5 h per week (OR = 3.6, 95%CI: 1.7, 7.5), agreeing that 'I tried to keep weight down not to look pregnant' (OR = 14.3, 95%CI: 1.4, 140.5). Other predictors only of having a discordant goal (vs. no goal) included agreeing that 'as long as I am eating well, I don't care how much I gain' (OR = 0.3, 95%CI: 0.2, 0.8) and agreeing that 'if I gain too much weight one month, I try to keep from gaining the next' (OR = 4.1, 95%CI: 1.6, 10.4). Women whose doctors recommended weight gains consistent with IOM guidelines were more likely to have a concordant goal (vs. no goal) (OR = 5.3, 95%CI: 1.5, 18.6). Engaging in healthy behaviors and having health providers offer IOM weight gain recommendations may increase the likelihood of having a concordant gestational weight gain goal, which, in turn, is predictive of actual weight gains that fall within IOM guidelines.


Asunto(s)
Objetivos , Aumento de Peso , Adulto , Femenino , Predicción , Encuestas Epidemiológicas , Humanos , Massachusetts , Registros Médicos , Embarazo
4.
J Clin Endocrinol Metab ; 94(2): 497-503, 2009 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19033373

RESUMEN

CONTEXT: Thyroid hormone is essential for normal brain development. Limited data are available regarding whether thyroid function in neonates influences later cognitive development. OBJECTIVE: Our objective was to study associations of newborn T4 levels with maternal thyroid function and childhood cognition. DESIGN AND SETTING: We studied participants in Project Viva, a cohort study in Massachusetts. PARTICIPANTS: We studied a total of 500 children born 1999--2003 at 34 wk or more. MAIN OUTCOME MEASURES: We determined cognitive test scores at ages 6 months and 3 yr. RESULTS: Mean newborn T4 at a mean age of 1.94 d was 17.6 (sd 4.0) microg/dl, and levels were higher in girls [1.07 microg/dl; 95% confidence interval (CI) 0.38, 1.76] and infants born after longer gestation (0.42 microg/dl; 95% CI 0.17, 0.67 per wk). Newborn T4 levels were not associated with maternal T4, TSH, or thyroid peroxidase antibody levels. On multivariable linear regression analysis, adjusting for maternal and child characteristics, higher newborn T4 was unexpectedly associated with poorer scores on the visual recognition memory test among infants at age 6 months (-0.5; 95% CI -0.9, -0.2), but not with scores at age 3 yr on either the Peabody Picture Vocabulary Test (0.2; 95% CI -0.1, 0.5) or the Wide Range Assessment of Visual Motor Abilities (0.1; 95% CI -0.2, 0.3). Maternal thyroid function test results were not associated with child cognitive test scores. CONCLUSIONS: Newborn T4 concentrations within a normal physiological reference range are not associated with maternal thyroid function and do not predict cognitive outcome in a population living in an iodine-sufficient area.


Asunto(s)
Desarrollo Infantil/fisiología , Cognición/fisiología , Madres , Glándula Tiroides/fisiología , Tiroxina/sangre , Adulto , Autoanticuerpos/sangre , Preescolar , Estudios de Cohortes , Dieta/efectos adversos , Femenino , Humanos , Lactante , Recién Nacido , Yodo/farmacología , Masculino , Embarazo , Efectos Tardíos de la Exposición Prenatal/sangre , Efectos Tardíos de la Exposición Prenatal/etiología , Efectos Tardíos de la Exposición Prenatal/fisiopatología , Desempeño Psicomotor/fisiología , Pruebas de Función de la Tiroides
6.
Am J Clin Nutr ; 92(5): 1234-40, 2010 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20844071

RESUMEN

BACKGROUND: Many pregnant women in the United States do not consume enough docosahexaenoic acid (DHA)--an essential nutrient found in fish. Apparently conflicting findings that fish consumption is beneficial for the developing fetus, yet potentially toxic because of mercury contamination, have created uncertainty about the appropriate fish-consumption advice to provide to pregnant women. OBJECTIVE: Our objective was to determine knowledge, behaviors, and received advice regarding fish consumption among pregnant women who are infrequent consumers of fish. DESIGN: In 2009-2010 we conducted 5 focus groups with 22 pregnant women from the Boston area who ate <2 fish servings/wk. We analyzed transcripts by using immersion-crystallization. RESULTS: Many women knew that fish might contain mercury, a neurotoxin, and had received advice to limit fish intake. Fewer women knew that fish contains DHA or what the function of DHA is. None of the women had received advice to eat fish, and most had not received information about which fish types contain more DHA or less mercury. Because of advice to limit fish intake, as well as a lack of information about which fish types they should be eating, many of the women said that they would rather avoid fish than possibly harm themselves or their infants. The participants thought that a physician's advice to eat fish and a readily available reference regarding which fish are safe to consume during pregnancy would likely have encouraged them to eat more fish. CONCLUSION: Pregnant women might be willing to eat more fish if this were advised by their obstetricians or if they had an accessible reference regarding which types are safe.


Asunto(s)
Dieta , Ácidos Docosahexaenoicos , Peces , Contaminación de Alimentos , Conocimientos, Actitudes y Práctica en Salud , Mercurio/toxicidad , Embarazo , Alimentos Marinos , Adulto , Animales , Boston , Femenino , Humanos , Alimentos Marinos/efectos adversos , Adulto Joven
7.
J Womens Health (Larchmt) ; 19(1): 65-70, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-20088660

RESUMEN

OBJECTIVE: Maternal obesity is associated with adverse pregnancy outcomes. To improve outcomes, obstetric providers must effectively evaluate and manage their obese pregnant patients. We sought to determine the knowledge, attitudes, and practice patterns of obstetric providers regarding obesity in pregnancy. METHODS: In 2007-2008, we surveyed 58 practicing obstetricians, nurse practitioners, and certified nurse-midwives at a multispecialty practice in Massachusetts. We administered a 26-item questionnaire that included provider self-reported weight, sociodemographic characteristics, knowledge, attitudes, and management practices. We created an 8-point score for adherence to 8 practices recommended by the American College of Obstetricians and Gynecologists (ACOG) for the management of obese pregnant women. RESULTS: Among the respondents, 37% did not correctly report the minimum body mass index (BMI) for diagnosing obesity, and most reported advising gestational weight gains that were discordant with 1990 Institute of Medicine (IOM) guidelines, especially for obese women (71%). The majority of respondents almost always recommended a range of weight gain (74%), advised regular physical activity (74%), or discussed diet (64%) with obese mothers, but few routinely ordered glucose tolerance testing during the first trimester (26%), planned anesthesia referrals (3%), or referred patients to a nutritionist (14%). Mean guideline adherence score was 3.4 (SD 1.9, range 0-8). Provider confidence (beta = 1.0, p = 0.05) and body satisfaction (beta = 1.5, p = 0.02) were independent predictors of higher guideline adherence scores. CONCLUSIONS: Few obstetric providers were fully compliant with clinical practice recommendations, defined obesity correctly, or recommended weight gains concordant with IOM guidelines. Provider personal factors were the strongest correlates of self-reported management practices. Our findings suggest a need for more education around BMI definitions and weight gain guidelines, along with strategies to address provider personal factors, such as confidence and body satisfaction, that may be important predictors of adherence to recommendations for managing obese pregnant women.


Asunto(s)
Competencia Clínica , Obesidad , Obstetricia/normas , Complicaciones del Embarazo , Atención Prenatal/normas , Índice de Masa Corporal , Dieta , Ejercicio Físico , Femenino , Adhesión a Directriz/estadística & datos numéricos , Humanos , Massachusetts , Obesidad/diagnóstico , Obesidad/prevención & control , Enfermería Obstétrica/normas , Relaciones Médico-Paciente , Pautas de la Práctica en Medicina/normas , Pautas de la Práctica en Medicina/estadística & datos numéricos , Embarazo , Complicaciones del Embarazo/diagnóstico , Complicaciones del Embarazo/prevención & control , Atención Prenatal/métodos , Sociedades Médicas/normas , Encuestas y Cuestionarios , Aumento de Peso/fisiología
8.
Endocr Pract ; 14(1): 33-9, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18238739

RESUMEN

OBJECTIVE: To determine first-trimester thyroid function values and associations with thyroperoxidase antibody (TPO-Ab) status, smoking, emesis, and iodine-containing multivitamin use. METHODS: We collected information by interview, questionnaire, and blood draw at the initial obstetric visit in 668 pregnant women without known thyroid disease. We compared thyroid-stimulating hormone (TSH), total thyroxine (T4), and free T4 index (FT4I) values by TPO-Ab status. Multiple regression was used to identify characteristics associated with thyroid function values. RESULTS: The following median (range containing 95% of the data points) thyroid function test values were obtained in 585 TPO-Ab-negative women: TSH, 1.1 mIU/L (0.04-3.6); FT4I, 2.1 (1.5-2.9); and T4, 9.9 microg/dL (7.0-14.0). The following median (range containing 95% of the data points) thyroid function test values were obtained in 83 TPO-Ab-positive women: TSH, 1.8 mIU/L (0.3-6.4) (P<.001); FT4I, 2.0 (1.4-2.7) (P = .06); and T4, 9.3 microg/dL (6.8-13.0) (P = .03) (P values denote statistically significant differences between TPO-Ab-positive and negative participants). Among TPO-Ab-negative participants, TSH level was not associated with use of iodine-containing multivitamins, smoking, or race. TSH increased 0.03 mIU/L for every year of maternal age (P = .03) and decreased by 0.3 mIU/L for every increase in parity (P<.001). T4 decreased 0.04 microg/dL for every year of maternal age (P = .04). Mean FT4I was 2.05 in smokers and 2.20 in nonsmokers (P<.01). There were no relationships between T4 or FT4I and parity, race, or iodine-containing multivitamin use. CONCLUSION: TPO-Ab status of pregnant women should be considered when constructing trimester-specific reference ranges because elevated serum TPO-Ab levels are associated with higher TSH and lower T4 values.


Asunto(s)
Autoanticuerpos/sangre , Autoantígenos/inmunología , Suplementos Dietéticos/estadística & datos numéricos , Yoduro Peroxidasa/inmunología , Proteínas de Unión a Hierro/inmunología , Primer Trimestre del Embarazo/sangre , Fumar , Pruebas de Función de la Tiroides , Adolescente , Adulto , Femenino , Humanos , Embarazo , Primer Trimestre del Embarazo/etnología , Primer Trimestre del Embarazo/inmunología , Primer Trimestre del Embarazo/metabolismo , Atención Prenatal , Fumar/fisiopatología , Hormonas Tiroideas/sangre , Tirotropina/sangre , Vitaminas/farmacología
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