RESUMEN
BACKGROUND AND PURPOSE: Animal data suggest the use of beta-human chorionic gonadotropin followed by erythropoietin to promote brain repair after stroke. The current study directly translated these results by evaluating safety of this sequential growth factor therapy through a 3-center, single-dose, open-label, noncontrolled, Phase IIa trial. METHODS: Patients with ischemic stroke 24 to 48 hours old and National Institutes of Health Stroke Scale score of 6 to 24 started a 9-day course of beta-human chorionic gonadotropin (once daily on Days 1, 3, and 5 of study participation) followed by erythropoietin (once daily on Days 7, 8, and 9 of study participation). This study also evaluated performance of serially measured domain-specific end points. RESULTS: A total of 15 patients were enrolled. Two deaths occurred, neither related to study medications. No safety concerns were noted among clinical or laboratory measures, including screening for deep vein thrombosis and serial measures of serum hemoglobin. In several instances, domain-specific end points provided greater insight into impairments as compared with global outcome measures. CONCLUSIONS: Results support the safety of this sequential, 2-growth factor therapy initiated 24 to 48 hours after stroke onset.
Asunto(s)
Isquemia Encefálica/tratamiento farmacológico , Gonadotropina Coriónica Humana de Subunidad beta/administración & dosificación , Gonadotropina Coriónica Humana de Subunidad beta/efectos adversos , Eritropoyetina/administración & dosificación , Eritropoyetina/efectos adversos , Accidente Cerebrovascular/tratamiento farmacológico , Adulto , Anciano , Anciano de 80 o más Años , Isquemia Encefálica/complicaciones , Isquemia Encefálica/patología , Quimioterapia Combinada , Femenino , Hemoglobinas/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Accidente Cerebrovascular/complicaciones , Accidente Cerebrovascular/patología , Trombosis de la Vena/etiología , Adulto JovenRESUMEN
Studies have suggested that consciousness is encoded discretely in time and synchronously in space of the brain. The present study was to model the alpha EEG as a brain clock to carry out the functions and to test whether the quality and rate of the oscillation could predict behavioral timing. Results showed that the alpha peak frequency was correlated with the conflict reaction time, and the selectivity was associated with the simple reaction time. These findings are consistent with previous reports and support the hypothesis that alpha EEG represents excitability cycles and may serves as a brain clock for spatial synchronization.