Coupled waveguide model for computing phase and transmission through nanopillar-based metasurfaces.

Dielectric metasurfaces are important in modern photonics due to their unique beam shaping capabilities. However, the standard tools for the computation of the phase and transmission through a nanopillar-based metasurface are either simple, approximating the properties of the surface by that of a single cylinder, or use full 3D numerical simulations. Here we introduce a new analytical model for computing metasurface properties which explicitly takes into account the effect of the lattice geometry. As an example we investigate silicon nanopillar-based metasurfaces, examining how the transmission properties depend on the presence of different modes in the unit cell of the metasurface array. We find that the new model outperforms the isolated cylinder model in predicting the phase, and gives excellent agreement with full numerical simulations when the fill fraction is moderate. Our model offers a waveguide perspective for comprehending metasurface properties, linking it to fiber optics and serving as a practical tool for future metasurface design.

Suspended mid-infrared waveguides for Stimulated Brillouin Scattering.

We theoretically investigate a new class of silicon waveguides for achieving Stimulated Brillouin Scattering (SBS) in the mid-infrared (MIR). The waveguide consists of a rectangular core supporting a low-loss optical mode, suspended in air by a series of transverse ribs. The ribs are patterned to form a finite quasi-one-dimensional phononic crystal, with the complete stopband suppressing the transverse leakage of acoustic waves, confining them to the core of the waveguide. We derive a theoretical formalism that can be used to compute the opto-acoustic interaction in such periodic structures, and find forward intramodal-SBS gains up to 1750 m-1W-1, which compares favorably with the proposed MIR SBS designs based on buried germanium waveguides. This large gain is achieved thanks to the nearly complete suppression of acoustic radiative losses.

Stimulated Brillouin scattering in layered media: nanoscale enhancement of silicon.

We report a theoretical study of stimulated Brillouin scattering (SBS) in general anisotropic media, incorporating the effects of both acoustic strain and local rotation. We apply our general theoretical framework to compute the SBS gain for layered media with periodic length scales smaller than all optical and acoustic wavelengths, where such composites behave like homogeneous anisotropic media. We predict that a layered medium composing nanometer-thin layers of silicon and As2S3 glass has a bulk SBS gain of 1.28×10-9 W-1 m. This is more than 500 times larger than that of silicon and almost double the gain of As2S3. The enhancement is due to a combination of roto-optic, photoelastic, and artificial photoelastic contributions in the composite structure.

Stimulated Brillouin scattering enhancement in silicon inverse opal waveguides.

Silicon is an ideal material for on-chip applications, however its poor acoustic properties limit its performance for important optoacoustic applications, particularly for stimulated Brillouin scattering (SBS). We theoretically show that silicon inverse opals exhibit a strongly improved acoustic performance that enhances the bulk SBS gain coefficient by more than two orders of magnitude. We also design a waveguide that incorporates silicon inverse opals and which has SBS gain values that are comparable with chalcogenide glass waveguides. This research opens new directions for opto-acoustic applications in on-chip material systems.

Metamaterial control of stimulated Brillouin scattering.

Using full opto-acoustic numerical simulations, we demonstrate enhancement and suppression of the SBS gain in a metamaterial comprising a subwavelength cubic array of dielectric spheres suspended in a dielectric background material. We develop a general theoretical framework and present several numerical examples using technologically important materials. For As2S3 spheres in silicon, we achieve a gain enhancement of more than an order of magnitude compared to pure silicon and for GaAs spheres in silicon, full suppression is obtained. The gain for As2S3 glass can also be strongly suppressed by embedding silica spheres. The constituent terms of the gain coefficient are shown to depend in a complex way on the filling fraction. We find that electrostriction is the dominant effect behind the control of SBS in bulk media.

Reduced CD5(+) CD24(hi) CD38(hi) and interleukin-10(+) regulatory B cells in active anti-neutrophil cytoplasmic autoantibody-associated vasculitis permit increased circulating autoantibodies.

Pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is B cell-dependent, although how particular B cell subsets modulate immunopathogenesis remains unknown. Although their phenotype remains controversial, regulatory B cells (Bregs ), play a role in immunological tolerance via interleukin (IL)-10. Putative CD19(+) CD24(hi) CD38(hi) and CD19(+) CD24(hi) CD27(+) Bregs were evaluated in addition to their CD5(+) subsets in 69 patients with ANCA-associated vasculitis (AAV). B cell IL-10 was verified by flow cytometry following culture with CD40 ligand and cytosine-phosphate-guanosine (CpG) DNA. Patients with active disease had decreased levels of CD5(+) CD24(hi) CD38(hi) B cells and IL-10(+) B cells compared to patients in remission and healthy controls (HCs). As IL-10(+) and CD5(+) CD24(hi) CD38(hi) B cells normalized in remission within an individual, ANCA titres decreased. The CD5(+) subset of CD24(hi) CD38(hi) B cells decreases in active disease and rebounds during remission similarly to IL-10-producing B cells. Moreover, CD5(+) B cells are enriched in the ability to produce IL-10 compared to CD5(neg) B cells. Together these results suggest that CD5 may identify functional IL-10-producing Bregs . The malfunction of Bregs during active disease due to reduced IL-10 expression may thus permit ANCA production.

Power limits and a figure of merit for stimulated Brillouin scattering in the presence of third and fifth order loss.

We derive a set of design guidelines and a figure of merit to aid the engineering process of on-chip waveguides for strong Stimulated Brillouin Scattering (SBS). To this end, we examine the impact of several types of loss on the total amplification of the Stokes wave that can be achieved via SBS. We account for linear loss and nonlinear loss of third order (two-photon absorption, 2PA) and fifth order, most notably 2PA-induced free carrier absorption (FCA). From this, we derive an upper bound for the output power of continuous-wave Brillouin-lasers and show that the optimal operating conditions and maximal realisable Stokes amplification of any given waveguide structure are determined by a dimensionless parameter ℱ involving the SBS-gain and all loss parameters. We provide simple expressions for optimal pump power, waveguide length and realisable amplification and demonstrate their utility in two example systems. Notably, we find that 2PA-induced FCA is a serious limitation to SBS in silicon and germanium for wavelengths shorter than 2200nm and 3600nm, respectively. In contrast, three-photon absorption is of no practical significance.

Formal selection rules for Brillouin scattering in integrated waveguides and structured fibers.

We derive formal selection rules for Stimulated Brillouin Scattering (SBS) in structured waveguides. Using a group-theoretical approach, we show how the waveguide symmetry determines which optical and acoustic modes interact for both forward and backward SBS. We present a general framework for determining this interaction and give important examples for SBS in waveguides with rectangular, triangular and hexagonal symmetry. The important role played by degeneracy of the optical modes is illustrated. These selection rules are important for SBS-based device design and for a full understanding the physics of SBS in structured waveguides.

Germanium as a material for stimulated Brillouin scattering in the mid-infrared.

In a theoretical design study, we propose buried waveguides made of germanium or alloys of germanium and other group-IV elements as a CMOS-compatible platform for robust, high-gain stimulated Brillouin scattering (SBS) applications in the mid-infrared regime. To this end, we present numerical calculations for backward-SBS at 4 µm in germanium waveguides that are buried in silicon nitride. Due to the strong photoelastic anisotropy of germanium, we investigate two different orientations of the germanium crystal with respect to the waveguide's propagation direction and find considerable differences. The acoustic wave equation is solved including crystal anisotropy; acoustic losses are computed from the acoustic mode patterns and previously published material parameters.

Pathways to renal biopsy and diagnosis among patients with ANCA small-vessel vasculitis.

OBJECTIVES: Antineutrophil cytoplasmic antibody small-vessel vasculitis (ANCA-SVV) is an autoimmune systemic process increasingly recogniSed since the advent of antibody testing for the disease. Prompt diagnosis and institution of immunosuppressive therapy has been shown to improve patient outcome. The goal of this study was to better understand how patients navigate the health care system from symptom presentation to biopsy diagnosis, and to study the effects of prompt versus delayed diagnosis. METHODS: Disease symptoms and number of physicians seen prior to renal biopsy were assessed for 127 ANCA-SVV patients. Direct, delayed, and quest pathways to diagnosis and treatment of vasculitis were defined for both patients and providers. Kruskal-Wallis and Fisher exact tests were used to evaluate continual measures and compare categorical variables across pathways. RESULTS: Among patients who sought direct care, physician delay in referral to a nephrologist was common (49/127, 71%, p=0.0023). Patients who delayed seeking care also experienced a delayed diagnosis 57% of the time (p=0.0023). Patients presenting with prodromal flu or upper respiratory involvement were more likely to have a delay/quest patient pathway (56% and 55%, respectively) than a direct patient pathway (44%, p=0.033 and 45%, p=0.019, respectively). There was a trend for patients with more severe loss of renal function to have a more direct referral to a nephrologist. CONCLUSIONS: Delay in diagnosis of ANCA SVV may be due to lack of or non-specific symptoms, especially in patients who present with non-renal manifestations of disease. Better algorithms are needed to identify extra-renal manifestations, expedite diagnosis and improve patient outcomes.

Cavity enhanced stimulated Brillouin scattering in an optical chip for multiorder Stokes generation.

We report the first demonstration of on-chip cascaded stimulated Brillouin scattering (SBS). Cascaded SBS is characterized in a 4 cm long chalcogenide (As2S3) rib waveguide where the end facet reflections provide a monolithic Fabry-Perot (FP) resonator. The presence of the FP cavity reduces the Brillouin gain threshold, which enables observation of cascaded SBS at reduced pump powers. We observe up to three orders of Stokes waves in the backscattered signal at a coupled peak power of 1.34 W. Anti-Stokes waves due to four-wave mixing between the pump and the Stokes wave were observed in the forward spectrum.

Modes of shallow photonic crystal waveguides: semi-analytic treatment.

We investigate the formation of photonic crystal waveguide (PCW) modes within the framework of perturbation theory. We derive a differential equation governing the envelope of PCW modes constructed from weak perturbations using an effective mass formulation based on the Luttinger-Kohn method from solid-state physics. The solution of this equation gives the frequency of the mode and its field. The differential equation lends itself to simple analytic approximations which reduce the problem to that of solving slab waveguide modes. By using this model, we demonstrate that the nature of the projected band structure and corresponding Bloch functions are central to the behaviour of PCW modes. With this understanding, we explain why the odd mode in a hexagonal PCW spans the entire Brillouin zone while the even mode is cut off.

Tricho-hepatic-enteric syndrome (THES) without intractable diarrhoea.

Tricho-hepatic-enteric syndrome (THES) is a genetically heterogeneous rare syndrome (OMIM: 222470 (THES1) and 614602 (THES2)) that typically presents in the neonatal period with intractable diarrhoea, intra-uterine growth retardation (IUGR), facial dysmorphism, and hair and skin changes. THES is associated with pathogenic variants in either TTC37 or SKIV2L; both are components of the human SKI complex, an RNA exosome cofactor. We report an 8 year old girl who was diagnosed with THES by the Undiagnosed Disease Program-WA with compound heterozygous pathogenic variants in SKIV2L. While THES was considered in the differential diagnosis, the absence of protracted diarrhoea delayed definitive diagnosis. We therefore suggest that SKIV2L testing should be considered in cases otherwise suggestive of THES, but without the characteristic diarrhoea. We expand the phenotypic spectrum while reviewing the current knowledge on SKIV2L.

Nonlinear silicon-on-insulator waveguides for all-optical signal processing.

Values up to gamma=7 x 10(6)/(W km) for the nonlinear parameter are feasible if silicon-on-insulator based strip and slot waveguides are properly designed. This is more than three orders of magnitude larger than for state-of-the-art highly nonlinear fibers, and it enables ultrafast all-optical signal processing with nonresonant compact devices. At lambda=1.55 microm we provide universal design curves for strip and slot waveguides which are covered with different linear and nonlinear materials, and we calculate the resulting maximum gamma.

Bound soliton pairs in photonic crystal fiber.

We demonstrate experimentally the formation and stable propagation of bound soliton pairs in a highly nonlinear photonic crystal fiber. The bound pairs occur at a particular power as the consequence of high-order soliton fission. They propagate over long distances with constant inter-soliton frequency and time separation. During propagation, the soliton self-frequency shift causes the central frequency of the pairs to move towards longer wavelength. The formation and characteristics of the bound soliton pairs are confirmed numerically. We believe this to be the first experimental observation of such bound soliton pairs.

Models for guidance in kagome-structured hollow-core photonic crystal fibres.

We demonstrate by numerical simulation that the general features of the loss spectrum of photonic crystal fibres (PCF) with a kagome structure can be explained by simple models consisting of thin concentric hexagons or rings of glass in air. These easily analysed models provide increased understanding of the mechanism of guidance in kagome PCF, and suggest ways in which the high-loss resonances in the loss spectrum may be shifted.

The effect of gender norms on the association between violence and hope among girls in the Democratic Republic of the Congo.

BACKGROUND: Girls at early stages of adolescence are vulnerable to violence victimization in humanitarian contexts, but few studies examine factors that affect girls' hope in these settings. We assessed attitudes toward traditional gender norms as an effect modifier of the relationship between violence exposure and future orientation in displaced girls. METHODS: Secondary analysis, using multivariable regression of cross-sectional data from girls ages 10-14 in South Kivu, Democratic Republic of the Congo. Key variables of interest were attitudes toward intimate partner violence (IPV), Children's Hope Scale (CHS) score, and exposure to physical, emotional, and sexual violence within the last 12 months. Additional covariates included age, educational status, and territory. RESULTS: The interaction of exposure to violence and attitudes toward IPV magnified the association between violence exposure and lower CHS score for physical violence (ß = -0.09, p = 0.040) and unwanted sexual touching (ß = -0.20, p = 0.003) among girls age 10-14, when adjusting for other covariates. The interaction of exposure to violence and attitudes toward IPV magnified the association between violence exposure and lower CHS score for forced sex (ß = -0.22, p = 0.016) among girls age 13-14, when adjusting for covariates. Findings for emotional violence, any form of sexual violence, and coerced sex trended toward lower CHS scores for girls who reported higher acceptance of IPV, but did not reach significance. CONCLUSIONS: Findings support the utility of gender norms-transformative programming in increasing resilience of girls who have experienced sexual violence in humanitarian contexts.

Economic, social and mental health impacts of an economic intervention for female sexual violence survivors in Eastern Democratic Republic of Congo.

BACKGROUND: Conflict-affected communities face poverty and mental health problems, with sexual violence survivors at high risk for both given their trauma history and potential for exclusion from economic opportunity. To address these problems, we conducted a randomized controlled trial of a group-based economic intervention, Village Savings and Loans Associations (VSLA), for female sexual violence survivors in the Democratic Republic of Congo. METHODS: In March 2011, 66 VSLA groups, with 301 study participants, were randomized to the VSLA program or a wait-control condition. Data were collected prior to randomization, at 2-months post-program in June 2012, and 8-months later for VSLA participants only. Outcome data included measures of economic and social functioning and mental health severity. VSLA program effect was derived by comparing intervention and control participants' mean changes from baseline to 2-month follow-up. RESULTS: At follow-up, VSLA study women reported significantly greater per capita food consumption and significantly greater reductions in stigma experiences compared with controls. No other study outcomes were statistically different. At 8-month follow-up, VSLA participants reported a continued increase in per capita food consumption, an increase in economic hours worked in the prior 7 days, and an increase in access to social resources. CONCLUSIONS: While female sexual violence survivors with elevated mental symptoms were successfully integrated into a community-based economic program, the immediate program impact was only seen for food consumption and experience of stigma. Impacts on mental health severity were not realized, suggesting that targeted mental health interventions may be needed to improve psychological well-being.

Modeling of defect modes in photonic crystals using the fictitious source superposition method.

We present an exact theory for modeling defect modes in two-dimensional photonic crystals having an infinite cladding. The method is based on three key concepts, namely, the use of fictitious sources to modify response fields that allow defects to be introduced, the representation of the defect mode field as a superposition of solutions of quasiperiodic field problems, and the simplification of the two-dimensional superposition to a more efficient, one-dimensional average using Bloch mode methods. We demonstrate the accuracy and efficiency of the method, comparing results obtained using alternative techniques, and then concentrate on its strengths, particularly in handling difficult problems, such as where a mode is highly extended near cutoff, that cannot be dealt with in other ways.

Acoustic build-up in on-chip stimulated Brillouin scattering.

We investigate the role of the spatial evolution of the acoustic field in stimulated Brillouin scattering processes in short high-gain structures. When the gain is strong enough that the gain length becomes comparable to the acoustic wave decay length of order 100 microns, standard approximations treating the acoustic field as a local response no longer apply. Treating the acoustic evolution more accurately, we find that the backward SBS gain of sub-millimetre long waveguides is significantly reduced from the value obtained by the conventional treatment because the acoustic mode requires several decay lengths to build up to its nominal value. In addition, the corresponding resonance line is broadened with the development of side bands. In contrast, we argue that intra-mode forward SBS is not expected to show these effects. Our results have implications for several recent proposals and experiments on high-gain stimulated Brillouin scattering in short semiconductor waveguides.