Detalles de la búsqueda
1.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533375
2.
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.
J Pharmacol Exp Ther
; 362(1): 31-44, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28416568
3.
The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS.
Hum Mol Genet
; 20(20): 3986-96, 2011 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21791548
4.
Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.
Front Pharmacol
; 14: 1190402, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37601062
5.
Irisin reduces amyloid-ß by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
Neuron
; 111(22): 3619-3633.e8, 2023 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37689059
6.
3-(N-arylsulfamoyl)benzamides, inhibitors of human sirtuin type 2 (SIRT2).
Bioorg Med Chem Lett
; 22(8): 2789-93, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22446090
7.
Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease.
Phytomedicine
; 104: 154158, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35728383
8.
Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer's Disease.
J Alzheimers Dis
; 80(2): 775-786, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33579853
9.
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor.
Circulation
; 115(17): 2292-8, 2007 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17420353
10.
Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid ß-Protein by Promoting Microglial Phagocytosis.
Sci Rep
; 8(1): 1144, 2018 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-29348604
11.
A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity.
Mol Cancer Ther
; 5(8): 1944-9, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16928814
12.
3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish".
Mol Neurodegener
; 11(1): 75, 2016 12 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27938410
13.
LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.
J Huntingtons Dis
; 5(4): 347-355, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27983565
14.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
Cell Chem Biol
; 23(7): 849-861, 2016 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-27427231
15.
Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.
ACS Med Chem Lett
; 6(5): 607-11, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26005542
16.
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
PLoS One
; 10(1): e0116919, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25608039
17.
Tyrosinase Models. Synthesis, Structure, Catechol Oxidase Activity, and Phenol Monooxygenase Activity of a Dinuclear Copper Complex Derived from a Triamino Pentabenzimidazole Ligand.
Inorg Chem
; 37(3): 553-562, 1998 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-11670307
18.
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Eur J Med Chem
; 76: 414-26, 2014 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24602787
19.
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
Cell Rep
; 2(6): 1492-7, 2012 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-23200855
20.
Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model.
PLoS Curr
; 22010 Sep 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-20877454