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1.
Opt Express ; 28(5): 6766-6780, 2020 Mar 02.
Artículo en Inglés | MEDLINE | ID: mdl-32225917

RESUMEN

In search of new technologies for optimizing the performance and space requirements of electronic and optical micro-circuits, the concept of spoof surface plasmon polaritons (SSPPs) has come to the fore of research in recent years. Due to the ability of SSPPs to confine and guide the energy of electromagnetic waves in a subwavelength space below the diffraction limit, SSPPs deliver all the tools to implement integrated circuits with a high integration rate. However, in order to guide SSPPs in the terahertz frequency range, it is necessary to carefully design metasurfaces that allow one to manipulate the spatio-temporal and spectral properties of the SSPPs at will. Here, we propose a specifically designed cut-wire metasurface that sustains strongly confined SSPP modes at terahertz frequencies. As we show by numerical simulations and also prove in experimental measurements, the proposed metasurface can tightly guide SSPPs on straight and curved pathways while maintaining their subwavelength field confinement perpendicular to the surface. Furthermore, we investigate the dependence of the spatio-temporal and spectral properties of the SSPP modes on the width of the metasurface lanes that can be composed of one, two or three cut-wires in the transverse direction. Our investigations deliver new insights into downsizing effects of guiding structures for SSPPs.

2.
Prostaglandins Other Lipid Mediat ; 146: 106387, 2020 02.
Artículo en Inglés | MEDLINE | ID: mdl-31669255

RESUMEN

Epoxyeicosatrienoic acids (EETs) are potent lipid mediators with well-established effects in vascular tissues. Recent studies indicated an emerging role of these eicosanoids in metabolic diseases and the EET signaling pathway was shown to be involved in hepatic insulin sensitivity. However, compared to vascular tissues, there is only limited knowledge about the underlying signaling pathways in the liver. Therefore, we employed an LC-MS/MS-based time-resolved phosphoproteomics approach to characterize 11,12-EET-mediated signaling events in the liver cell line Hepa 1-6. 11,12-EET treatment resulted in the time-dependent regulation of phosphopeptides involved in processes as yet unknown to be affected by EETs, including RNA processing, splicing and translation regulation. Pathway analysis combined with western blot-based validation revealed enhanced AKT/mTOR/p70S6K signaling as demonstrated by increased acute phosphorylation of AKT (Ser473) and p70S6K (Thr389). In addition, 11,12-EET treatment led to differential regulation of phosphopeptides including important mediators of the DNA damage response and we observed a prolonged induction of the etoposide-induced DNA damage marker γH2AX in response to 11,12-EET. In summary, our findings extend current knowledge of 11,12-EET signaling events and emphasize the importance of the AKT/mTOR/p70S6K pathway in hepatic 11,12-EET signaling. Based on the results presented in this study, we furthermore propose a novel role of EET signaling in the regulation of the DNA damage response.


Asunto(s)
Ácido 8,11,14-Eicosatrienoico/análogos & derivados , Hígado/metabolismo , Proteómica , Transducción de Señal , Ácido 8,11,14-Eicosatrienoico/metabolismo , Línea Celular , Humanos , Fosfoproteínas
3.
Opt Express ; 25(17): 20850-20859, 2017 Aug 21.
Artículo en Inglés | MEDLINE | ID: mdl-29041762

RESUMEN

Efficient, high speed spatial modulators with predictable performance are a key element in any coded aperture terahertz imaging system. For spectroscopy, the modulators must also provide a broad modulation frequency range. In this study, we numerically analyze the electromagnetic behavior of a dynamically reconfigurable spatial terahertz wave modulator based on a micromirror grating in Littrow configuration. We show that such a modulator can modulate terahertz radiation over a wide frequency range from 1.7 THz to beyond 3 THz at a modulation depth of more than 0.6. As a specific example, we numerically simulated coded aperture imaging of an object with binary transmissive properties and successfully reconstructed the image.

4.
Opt Express ; 24(21): 23863-23871, 2016 Oct 17.
Artículo en Inglés | MEDLINE | ID: mdl-27828221

RESUMEN

In single-pixel coded aperture terahertz-imaging, the individual pixel size in the spatial terahertz modulator is usually comparable to the terahertz wavelength in order to obtain a sufficient spatial image resolution. Therefore, diffraction plays an important role in the imaging process and must be accurately taken into account when the image is computationally retrieved. For this reason, we analyzed the impact of diffraction from the spatial terahertz modulator on the quality of the reconstructed image in single-pixel coded aperture imaging. We observed that the most important fraction of the image information is already contained in the zero order diffracted radiation. Higher diffraction orders do not contain enough information to retrieve the image from them solely, yet can contribute to an improved image quality when added to the zero order information.

5.
Opt Express ; 23(10): 12900-9, 2015 May 18.
Artículo en Inglés | MEDLINE | ID: mdl-26074543

RESUMEN

We demonstrate a terahertz time-domain spectroscope for spatially resolved pump-probe experiments which are based on terahertz probe pulse generation with a photo-conductive switch synchronized to the pump pulse generation of a nanosecond laser. The accessible pump-probe delay ranges from 600 ps up to 200 µs. The spatial resolution of the spectroscope is better than 50 µm. We use the measurement system for spatially resolved lifetime mapping of photo-induced carriers in thin silicon in dependence on the photoexcitation intensity of the pump laser. At an optical pump intensity of 70mW/cm2, we measured a carrier lifetime of 15.7 µs for silicon with 200 µm thickness and a much shorter carrier lifetime of 233 ns for 30 µm thick silicon.

6.
Opt Lett ; 38(12): 2156-8, 2013 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-23939008

RESUMEN

We designed and implemented a gradient index metasurface for in-plane focusing of confined terahertz (THz) surface waves. We measured the spatial propagation of the surface waves by two-dimensional mapping of the complex electric field using a THz near-field spectroscope. The surface waves were focused to a diameter of 500 µm after a focal length of approximately 2 mm. In the focus, we measured a field amplitude enhancement of a factor of 3.

7.
Opt Express ; 20(8): 8982-97, 2012 Apr 09.
Artículo en Inglés | MEDLINE | ID: mdl-22513609

RESUMEN

The technique of transformation optics (TO) is an elegant method for the design of electromagnetic media with tailored optical properties. In this paper, we focus on the formal structure of TO theory. By using a complete covariant formalism, we present a general transformation law that holds for arbitrary materials including bianisotropic, magneto-optical, nonlinear and moving media. Due to the principle of general covariance, the formalism is applicable to arbitrary space-time coordinate transformations and automatically accounts for magneto-electric coupling terms. The formalism is demonstrated for the calculation of the second harmonic wave generation in a twisted TO concentrator.

8.
iScience ; 25(5): 104319, 2022 May 20.
Artículo en Inglés | MEDLINE | ID: mdl-35602944

RESUMEN

Recent developments in nanomagnetism and spintronics have enabled the use of ultrafast spin physics for terahertz (THz) emission. Spintronic THz emitters, consisting of ferromagnetic (FM)/non-magnetic (NM) thin film heterostructures, have demonstrated impressive properties for the use in THz spectroscopy and have great potential in scientific and industrial applications. In this work, we focus on the impact of the FM/NM interface on the THz emission by investigating Fe/Pt bilayers with engineered interfaces. In particular, we intentionally modify the Fe/Pt interface by inserting an ordered L10-FePt alloy interlayer. Subsequently, we establish that a Fe/L10-FePt (2 nm)/Pt configuration is significantly superior to a Fe/Pt bilayer structure, regarding THz emission amplitude. The latter depends on the extent of alloying on either side of the interface. The unique trilayer structure opens new perspectives in terms of material choices for the next generation of spintronic THz emitters.

9.
Opt Express ; 19(23): 23573-80, 2011 Nov 07.
Artículo en Inglés | MEDLINE | ID: mdl-22109237

RESUMEN

We report hybridization induced transparency (HIT) in a composite medium consisting of a metamaterial and a dielectric. We develop an analytic model that explains HIT by coherent coupling between the hybridized local fields of the metamaterial and the dielectric or an atomic system in general. In a proof-of-principle experiment, we evidence HIT in a split ring resonator metamaterial that is coupled to α-lactose monohydrate. Both, the analytic model and numerical calculations confirm and explain the experimental observations. HIT can be considered as a hybrid analogue to electromagnetically induced transparency (EIT) and plasmon-induced transparency (PIT).

10.
Opt Lett ; 35(9): 1320-2, 2010 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-20436555

RESUMEN

We present experimental and numerical studies of localized terahertz surface waves on a subwavelength-thick metamaterial film consisting of in-plane split-ring resonators. A simple and intuitive model is derived that describes the propagation of surface waves as guided modes in a waveguide filled with a Lorentz-like medium. The effective medium model allows us to deduce the dispersion relation of the surface waves, in excellent agreement with the numerical data obtained from 3D full-wave calculations. Both the accuracy of the analytical model and the numerical calculations are confirmed by spectroscopic terahertz time-domain measurements.

11.
Opt Express ; 17(21): 18590-5, 2009 Oct 12.
Artículo en Inglés | MEDLINE | ID: mdl-20372589

RESUMEN

We present two types of metamaterial-based spectral bandpass filters for the terahertz (THz) frequency range. The metamaterials are specifically designed to operate for waves at normal incidence and to be independent of the field polarization. The functional structures are embedded in films of benzocyclobutene (BCB) resulting in large-area, free-standing and flexible membranes with low intrinsic loss. The proposed filters are investigated by THz time-domain spectroscopy and show a pronounced transmission peak with over 80% amplitude transmission in the passband and a transmission rejection down to the noise level in the stopbands. The measurements are supported by numerical simulations which evidence that the high transmission response is related to the excitation of trapped modes.

12.
Opt Express ; 17(2): 819-27, 2009 Jan 19.
Artículo en Inglés | MEDLINE | ID: mdl-19158896

RESUMEN

We present a polarization-independent metamaterial design for the construction of electrically tunable terahertz (THz) devices. The implemented structure consists of an array of gold crosses fabricated on top of an n-doped gallium arsenide (GaAs) layer. Utilizing THz time-domain spectroscopy, we show that the electric resonance and thus the transmission properties of the cross structure can be tuned by an externally applied bias voltage. We further demonstrate the fast amplitude modulation of a propagating THz wave for modulation frequencies up to 100 kHz.

13.
Sci Rep ; 9(1): 10792, 2019 Jul 25.
Artículo en Inglés | MEDLINE | ID: mdl-31346232

RESUMEN

Phase-gradient metasurfaces can be designed to manipulate electromagnetic waves according to the generalized Snell's law. Here, we show that a phased parallel-plate waveguide array (PPWA) can be devised to act in the same manner as a phase-gradient metasurface. We derive an analytic model that describes the wave propagation in the PPWA and calculate both the angle and amplitude distribution of the diffracted waves. The analytic model provides an intuitive understanding of the diffraction from the PPWA. We verify the (semi-)analytically calculated angle and amplitude distribution of the diffracted waves by numerical 3-D simulations and experimental measurements in a microwave goniometer.

14.
Sci Rep ; 9(1): 2597, 2019 Feb 22.
Artículo en Inglés | MEDLINE | ID: mdl-30796342

RESUMEN

We report the design, fabrication and experimental investigation of a spectrally wide-band terahertz spatial light modulator (THz-SLM) based on an array of 768 actuatable mirrors with each having a length of 220 µm and a width of 100 µm. A mirror length of several hundred micrometers is required to reduce diffraction from individual mirrors at terahertz frequencies and to increase the pixel-to-pixel modulation contrast of the THz-SLM. By means of spatially selective actuation, we used the mirror array as reconfigurable grating to spatially modulate terahertz waves in a frequency range from 0.97 THz to 2.28 THz. Over the entire frequency band, the modulation contrast was higher than 50% with a peak modulation contrast of 87% at 1.38 THz. For spatial light modulation, almost arbitrary spatial pixel sizes can be realized by grouping of mirrors that are collectively switched as a pixel. For fabrication of the actuatable mirrors, we exploited the intrinsic residual stress in chrome-copper-chrome multi-layers that forces the mirrors into an upstanding position at an inclination angle of 35°. By applying a bias voltage of 37 V, the mirrors were pulled down to the substrate. By hysteretic switching, we were able to spatially modulate terahertz radiation at arbitrary pixel modulation patterns.

15.
Sci Rep ; 9(1): 13348, 2019 Sep 16.
Artículo en Inglés | MEDLINE | ID: mdl-31527771

RESUMEN

Spintronic ferromagnetic/non-magnetic heterostructures are novel sources for the generation of THz radiation based on spin-to-charge conversion in the layers. The key technological and scientific challenge of THz spintronic emitters is to increase their intensity and frequency bandwidth. Our work reveals the factors to engineer spintronic Terahertz generation by introducing the scattering lifetime and the interface transmission for spin polarized, non-equilibrium electrons. We clarify the influence of the electron-defect scattering lifetime on the spectral shape and the interface transmission on the THz amplitude, and how this is linked to structural defects of bilayer emitters. The results of our study define a roadmap of the properties of emitted as well as detected THz-pulse shapes and spectra that is essential for future applications of metallic spintronic THz emitters.

16.
Cell Rep ; 29(4): 873-888.e10, 2019 10 22.
Artículo en Inglés | MEDLINE | ID: mdl-31644910

RESUMEN

The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phospho-specific antibodies reveal that CBM-associated MALT1 is transiently hyper-phosphorylated upon TCR/CD28 co-stimulation. We identify a dual role for CK1α as a kinase that is essential for CBM signalosome assembly as well as MALT1 phosphorylation. Although MALT1 phosphorylation is largely dispensable for protease activity, it fosters canonical NF-κB signaling in Jurkat and murine CD4 T cells. Moreover, constitutive MALT1 phosphorylation promotes survival of activated B cell-type diffuse large B cell lymphoma (ABC-DLBCL) cells addicted to chronic BCR signaling. Thus, MALT1 phosphorylation triggers optimal NF-κB activation in lymphocytes and survival of lymphoma cells.


Asunto(s)
Activación de Linfocitos , Linfoma de Células B Grandes Difuso/inmunología , Proteína 1 de la Translocación del Linfoma del Tejido Linfático Asociado a Mucosas/metabolismo , Transducción de Señal , Linfocitos T/inmunología , Secuencias de Aminoácidos , Animales , Proteína 10 de la LLC-Linfoma de Células B/metabolismo , Proteínas Adaptadoras de Señalización CARD/metabolismo , Antígenos CD28/metabolismo , Caseína Quinasa Ialfa/metabolismo , Células Cultivadas , Guanilato Ciclasa/metabolismo , Células HEK293 , Humanos , Células Jurkat , Ratones , Ratones Endogámicos C57BL , Proteína 1 de la Translocación del Linfoma del Tejido Linfático Asociado a Mucosas/química , FN-kappa B/metabolismo , Fosforilación
17.
ACS Nano ; 6(10): 9118-24, 2012 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-22992128

RESUMEN

New applications in the realms of terahertz (THz) technology require versatile adaptive optics and powerful modulation techniques. Semiconductors have proven to provide fast all-optical terahertz wave modulation over a wide frequency band. We show that the attenuation and modulation depth in optically driven silicon modulators can be significantly enhanced by deposition of graphene on silicon (GOS). We observed a wide-band tunability of the THz transmission in a frequency range from 0.2 to 2 THz and a maximum modulation depth of 99%. The maximum difference between the transmission through silicon and GOS is Δt = 0.18 at a low photodoping power of 40 mW. At higher modulation power, the enhancement decreased due to charge carrier saturation. We developed a semianalytical band structure model of the graphene-silicon interface to describe the observed attenuation and modulation depth in GOS.


Asunto(s)
Grafito/química , Nanoestructuras/química , Nanoestructuras/ultraestructura , Refractometría/instrumentación , Telecomunicaciones/instrumentación , Diseño de Equipo , Análisis de Falla de Equipo , Tamaño de la Partícula , Radiación Terahertz
18.
Phys Rev E Stat Nonlin Soft Matter Phys ; 81(4 Pt 2): 048601, 2010 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-20481865

RESUMEN

The metamaterial presented by Yan [Phys. Rev. E 77, 056604 (2008)] is claimed to exhibit a superwide band of negative refraction. However, a retrieval procedure of the refractive index including the phase advance of a propagating plane wave shows that the material provides two distinct narrow bands with a negative refractive index instead of a single superwide band and thus the central claim of the paper is incorrect.

19.
Phys Rev Lett ; 100(6): 063903, 2008 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-18352474

RESUMEN

Transformation optics offers an unconventional approach to the control of electromagnetic fields. The transformation optical structures proposed to date, such as electromagnetic "invisibility" cloaks and concentrators, are inherently reflectionless and leave the transmitted wave undisturbed. Here, we expand the class of transformation optical structures by introducing finite, embedded coordinate transformations, which allow the electromagnetic waves to be steered or focused. We apply the method to the design of several devices, including a parallel beam shifter and a beam splitter, both of which are reflectionless and exhibit unusual electromagnetic behavior as confirmed by 2D full-wave simulations.

20.
Phys Rev Lett ; 100(2): 024301, 2008 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-18232873

RESUMEN

Through acoustic scattering theory we derive the mass density and bulk modulus of a spherical shell that can eliminate scattering from an arbitrary object in the interior of the shell--in other words, a 3D acoustic cloaking shell. Calculations confirm that the pressure and velocity fields are smoothly bent and excluded from the central region as for previously reported electromagnetic cloaking shells. The shell requires an anisotropic mass density with principal axes in the spherical coordinate directions and a radially dependent bulk modulus. The existence of this 3D cloaking shell indicates that such reflectionless solutions may also exist for other wave systems that are not isomorphic with electromagnetics.

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