Distribution of C-arm projections in native and bioprosthetic aortic valves cusps: Implication for BASILICA procedures.

OBJECTIVES: We sought to document aortic cusps fluoroscopic projections and their distributions using leaflet alignment which is a novel concept to optimize visualization of leaflets and for guiding BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent coronary artery obstruction) and determine whether these projections were feasible in catheter laboratory. BACKGROUND: Optimal fluoroscopic projections of aortic valve cusps have not been well described. METHODS: A total of 128 pre-transcatheter aortic valve replacement (pre-TAVR) computed tomographies (CT) (72 native valves and 56 bioprosthetic surgical valves) were analyzed. Using CT software (3Mensio, Pie medical imaging, the Netherlands), leaflet alignment was performed and the feasibility of these angles, which were defined as rate of obtainable with efforts (within LAO/RAO of 85° and CRA/CAU of 50°) were evaluated. RESULTS: High feasibility was seen in right coronary cusp (RCC) front view (100%) and left coronary cusp (LCC) side view (99.2%), followed by noncoronary cusp side view (95.3%). In contrast, low feasibility of RCC side view (7.8%) and LCC front view (47.6%) was observed. No statistical differences were seen between the distribution of native valves and bioprosthetic surgical valves. With patient/table tilt of 20°LAO and 10°CRA, the feasibility of RCC side view and LCC front view increased to 43.7 and 85.2%, respectively. CONCLUSION: Distributions of each cusp's leaflet alignment follows "sigmoid curve" which can provide better understanding of aortic valve cusp orientation in TAVR and BASILICA. RCC side view used in right cusp BASILICA is commonly unachievable in catheter laboratory and may improve with patient/table tilt.

Caliber and fitness of the axillary artery as a conduit for large-bore cardiovascular procedures.

OBJECTIVES: We sought to describe the caliber and vascular health of the subclavian and axillary arteries as related to their potential utilization in complex cardiovascular procedures. BACKGROUND: Patients referred for advanced catheter-based therapies frequently have lower extremity peripheral vascular disease that may prohibit the use of large bore arterial catheters. Utilization of the upper extremity peripheral vasculature is rarely considered as an alternative access strategy. This may be due in part to a lack of familiarity with the thoracic vasculature. METHODS AND RESULTS: 208 consecutive patients undergoing routine CTA prior to transcatheter aortic valve replacement were retrospectively evaluated in a systematic analysis of upper and lower extremity vasculature. Minimal luminal diameters (MLDs) for the axillary arteries and iliofemoral arteries were 6.0 ± 1.1 mm and 6.6 ± 1.8 mm respectively. Compared to the iliofemoral arteries, the axillary arteries demonstrated substantially lower rates of significant stenosis (2% vs. 12%, p < 0.01) and significantly lower rates of moderate to severe calcification disease (9% vs. 64%, p < 0.01). Diabetes and tobacco use were independently associated with smaller axillary artery caliber by MLD (p < 0.01) but not with significant stenotic disease. CONCLUSIONS: The axillary arteries are slightly smaller but less frequently diseased than the corresponding iliofemoral vessels.

Indicators and characteristics of PET packaging collected in a Deposit and Refund System pilot project.

Countries that have a Deposit and Refund System (DRS) show high rates of selective beverage packaging waste collection, indicating that it is a powerful economic instrument for achieving the European packaging recycling targets. DRS ensure that collected material is of a sufficiently high quality to be incorporated into new products. In Portugal, the Government has decided to implement a DRS for non-reusable beverage packaging as a strategy to increase the packaging recycling rate, which is currently considerably lower than the mandatory European targets. To acquire knowledge and experience for the design and implementation of the future DRS, a pilot project was carried out with polyethylene terephthalate (PET) beverage packaging, using 23 Reverse Vending Machines (RVM) installed at supermarkets across mainland Portugal. The authors monitored the DRS pilot project between March 2020 and December 2022. The main objectives were to determine operational indicators and evaluate the characteristics and quality of the PET deposited, using both the data recorded by the RVM and a characterisation of the packages contained in a sample of 46 bags. The results provided important data for planning the Portuguese strategy, which may also support operational or political decisions in countries in similar contexts. Whilst the recycling plants that received the material collected in these RVM confirmed that its quality allows for the production of PET food-grade flakes, this research identified a need to improve the design of packaging and to communicate this with producers, to better allow for the incorporation of recycled material into food beverage packaging.

Transparent and Colorless Luminescent Solar Concentrators Based on ZnO Quantum Dots for Building-Integrated Photovoltaics.

Scientific interest in luminescent solar concentrators (LSCs) has reemerged mainly due to the application of semiconductor quantum dots (QDs) as highly efficient luminophores. Recently, LSCs have become attractive proposals for Building-Integrated photovoltaics (BIPV) since they could help conventional photovoltaics to improve sunlight harvesting and reduce production costs. However, most of the modern LSCs rely on heavy-metal QDs which are highly toxic and may cause environmental concerns. Additionally, their absorption spectra give them a characteristic color limiting their potential application in BIPV. Herein, we fabricated transparent and colorless LSCs by embedding nontoxic and cost-effective zinc oxide quantum dots (ZnO QDs) in a PMMA polymer matrix (ZnO-LSC), preserving the QD optical properties and PMMA transparency. The synthesized colloidal ZnO QDs have an average size of 5.5 nm, a hexagonal wurtzite crystalline structure, a broad yellow photoluminescent signal under ultraviolet excitation, and are highly visibly transparent at the employed concentrations (>95% in wavelengths above 400 nm). The optical characterization of the fabricated ZnO-LSCs showed a good visible transparency of 80.3% average visible transmission (AVT), with an LSC concentration factor (C) of 1.02. An optimal device (ZnO-LSC-O) could reach a C value of 2.66 with the combination of optical properties of colloidal ZnO QDs and PMMA. Finally, simulations of the performance of silicon solar cells coupled to the fabricated and optimal LSCs under standard AM 1.5G illumination were performed employing the software COMSOL Multiphysics. The fabricated ZnO-LSC achieved a simulated maximum power conversion efficiency (PCE) of 3.80%, while the optimal ZnO-LSC-O reached 5.45%. Also, the ZnO-LSC generated a maximum power of 15.02 mW and the ZnO-LSC-O generated 40.33 mW, employing the same active area as the simulated solar cell directly illuminated, which generated 14.39 mW. These results indicate that the ZnO QD-based LSCs may be useful as transparent photovoltaic windows for BIPV applications.

Exploring Clinical Remission in Moderate Asthma - Perspectives from Asia, the Middle East, and South America.

INTRODUCTION: Clinical remission is a relatively new concept in asthma but recent research initiatives suggest it could be an ambitious and achievable therapeutic target for patients with asthma. METHODS: In this modified Delphi study (comprising two online surveys, completed either side of a virtual scientific workshop), the opinions of a panel of respiratory physicians were evaluated to summarize perspective statements on key therapeutic outcomes and criteria for on-treatment clinical remission in patients with moderate asthma. An agreement threshold was pre-defined as agreement by ≥ 75% of participants. RESULTS: Surveys 1 and 2 were completed by 20 and 18 participants, respectively. Most participants (95%) agreed with the concept of clinical remission in moderate asthma and that this should be a desirable treatment goal (90%). Based on a composite measure of 4-6 desirable therapeutic outcomes, current understanding of clinical remission was considered as 12 months with no exacerbations, no oral corticosteroids, no daytime or night-time asthma symptoms (Asthma Control Test score ≥ 20 or Asthma Control Questionnaire score ≤ 0.75), stable lung function, and no treatment-related adverse events. No agreement was reached on the role of relievers in defining therapeutic outcomes or on the wider use of biomarkers and airway hyperresponsiveness for defining asthma remission in clinical practice. CONCLUSIONS: In line with recent consensus statements from the United States and Europe, there was a high level of agreement on the elements of clinical remission among a panel of respiratory physicians from Asia, the Middle East, and South America. Extension of the concept of clinical remission to patients with moderate asthma was considered aligned with the potential of clinical remission as a goal of therapy.

Fractional exhaled nitric oxide has a good correlation with asthma control and lung function in latino children with asthma.

BACKGROUND: Although the measurement of fractional exhaled nitric oxide (FE(NO)) has been recommended for observational studies and clinical trials of asthma, FE(NO) has not been examined in studies of childhood asthma in Latin America, OBJECTIVE: To examine the relationship between FE(NO) and indicators of disease control or severity [asthma control test/childhood asthma control test (ACT/C-ACT), lung function, and exercise challenge test (ECT)] in Mexican children with persistent asthma, METHODS: Children (6-18 years of age) with persistent asthma were consecutively recruited in a tertiary asthma clinic and divided into two groups, e.g. FE(NO) < 20 parts per billion (ppb) and ≥20 ppb.Adequate FE(NO) measurements were obtained in 134 (83.2%) of 161 eligible children, RESULTS: Children with FE(NO)<20 ppb had significantly higher scores on the ACT/C-ACT than those with FE(NO) ≥ 20 ppb (median [interquartile range] :23 [20.8-25] vs. 21 [18-24], p = .002, respectively). Compared to children with FE(NO) ≥20 ppb, those with FE(NO) <20 ppb had a higher baseline predicted forced expiratory volume (FEV(1)) [94% (92.5%-99.4%) vs. 83% (81%-89.9%), p = .001] and a lower probability of having a positive ECT (42.7% vs. 71.2%, p = .001). In addition, FE(NO) was significantly inversely correlated with the participants' ACT/C-ACT score and predicted FEV1, and directly correlated with positive ECT, CONCLUSION: Among Mexican children with persistent asthma, low levels of FE(NO) ( <20 ppb) are associated with better asthma control, and higher lung function.

Strategies to promote construction and demolition waste management in the context of local dynamics.

Achieving a broad analysis of construction and demolition waste (CDW) management without considering local scale dynamics, and its detailed characteristics, is a constraint that has made it challenging to optimally engage in an integrated assessment of the circular economy principles in the construction sector. In this sense, this research demonstrates that investing in local strategies is important, involving municipalities and micro and small construction companies. Firstly, the results reveal the importance of having controlled sites, under local responsibility, for the preliminary storage of CDW, creating in waste producers the habit of separating waste onsite, reducing costs and limitations for municipalities. Secondly, frequent supervision actions at construction sites are also important at this scale, as they facilitate progress in terms of encouraging compliance with mandatory legal procedures and good practices for CDW management. But it is easier to improve practice through direct onsite procedures than it is with bureaucratic legal requirements alone. Thirdly, procedural control, implemented by municipal technicians in conjunction with other strategies, also helps to promote CDW management, this being associated with processes of public and private construction works subjected to license or prior control, in opposition to what has been accomplished so far. But the research also demonstrated that regular awareness, training, and supervision actions might increase the likelihood of improvements in behaviour on the local scale, in the sense that stakeholders acquire new habits, which, over time, might lead to better results locally and, as a consequence, influence other scales of intervention.

Polydioxanone Dome Technique for Guided Bone Regeneration: Surgical Technique and Results up to 72 Months of Follow-up.

This study aimed to describe the step-by-step procedure of the polydioxanone dome technique associated with guided bone regeneration (GBR) and to report the results up to 72 months after implant loading. Patients with maxillary horizontal bone defects (< 5 mm residual width, confirmed by CBCT scan) were treated with the proposed intervention. During the GBR procedure, four bone perforations were strategically prepared in a roughly square configuration. Segments of polydioxanone suture material were introduced in the perforations, forming a dome-shaped structure. Six months after bone augmentation, a new CBCT was performed. After implant restoration, periapical radiographs were taken, which were then repeated annually. The following outcomes were analyzed: implant survival, horizontal bone gain, marginal bone level, and complications. Twenty implants were placed in 11 patients with a survival rate of 100% in a mean follow-up of 38.18 ± 19.65 months after loading. Mean horizontal bone gain was 3.82 ± 1.67 mm and mean marginal bone level was -0.12 ± 1.17 mm. Only minor complications were observed. The present results suggest that the polydioxanone dome technique may represent a promising approach during horizontal GBR, alone or in combination with implant placement. Int J Periodontics Restorative Dent 2023;43:223-230. doi: 10.11607/prd.6087.

Polymeric nanoparticles and nanomicelles of hydroxychloroquine co-loaded with azithromycin potentiate anti-SARS-CoV-2 effect.

The outbreak of coronavirus (COVID-19) has put the world in an unprecedented scenario. To reestablish the world routine as promote the effective treatment of this disease, the world is looking for new (and old) drug that can efficiently kill the virus. In this study, we have developed two nanosystems: polymeric nanoparticles and nanomicelles-based on hydroxychloroquine and azithromycin. The nanosystem was fully characterized by AFM and DLS techniques. Also, the nanosystems were radiolabeled with 99mTc and pulmonary applied (installation) in vivo to evaluate the biological behavior. The toxicity of both nanosystem were evaluated in primary cells (FGH). Finally, both nanosystems were evaluated in vitro against the SARS-CoV-2. The results demonstrated that the methodology used to produce the nanomicelles and the nanoparticle was efficient, the characterization showed a nanoparticle with a spherical shape and a medium size of 390 nm and a nanomicelle also with a spherical shape and a medium size of 602 nm. The nanomicelles were more efficient (~ 70%) against SARS-CoV-2 than the nanoparticles. The radiolabeling process with 99mTc was efficient (> 95%) in both nanosystems and the pulmonary application demonstrated to be a viable route for both nanosystems with a local retention time of approximately, 24 h. None of the nanosystems showed cytotoxic effect on FGH cells, even in high doses, corroborating the safety of both nanosystems. Thus, claiming the benefits of the nanotechnology, especially with regard the reduced adverse we believe that the use of nanosystems for COVID-19 treatment can be an optimized choice. Supplementary Information: The online version contains supplementary material available at 10.1007/s40097-022-00476-3.

Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies.

Stroke is the most common cause of epilepsy and ultimately leads to a decrease in the quality of life of those affected. Ischemic and hemorrhagic strokes can both lead to poststroke epilepsy (PSE). Significant risk factors for PSE include age < 65age less than 65 years, stroke severity measured by the National Institutes of Health Stroke Scale (NIHSS), cortical involvement, and genetic factors such as TRPM6 polymorphism. The diagnosis of PSE is made by using imaging modalities, blood biomarkers, and prognostic criteria. Electroencephalography (EEG) is currently the gold standard to diagnose PSE, while new combinations of modalities are being tested to increase diagnostic specificity. This literature review uncovers a newly found mechanism for the pathology of poststroke epilepsy. The pathogenesis of early-onset and late-onset is characterized by sequelae of neuronal cellular hypoxia and disruption of the blood-brain barrier, respectively. Interleukin-6 is responsible for increasing the activity of glial cells, causing gliosis and hyperexcitability of neurons. Epinephrine, high-mobility group protein B1, downregulation of CD32, and upregulation of HLA-DR impact the pathology of poststroke epilepsy by inhibiting the normal neuronal immune response. Decreased levels of neuropeptide Y, a neurotransmitter, act through multiple unique mechanisms, such as inhibiting intracellular Ca2+ accumulation and acting as an anti-inflammatory, also implemented in the worsening progression of poststroke epilepsy. Additionally, CA1 hippocampal resonant neurons that increase theta oscillation are associated with poststroke epilepsy. Hypertensive small vessel disease may also have an implication in the temporal lobe epilepsy by causing occult microinfarctions. Furthermore, this review highlights the potential use of statins as primary prophylaxis against PSE, with multiple studies demonstrating a reduction in incidence using statins alone, statins in combination with antiepileptic drugs (AEDs), and statins with aspirin. The evidence strongly suggests that the second generation AEDs are a superior treatment method for PSE. Data from numerous studies demonstrate their relative lack of significant drug interactions, increased tolerability, and potential superiority in maintaining seizure-free status.

Influence of construction company size on the determining factors for construction and demolition waste management.

Due to the relevance of construction and demolition waste (CDW) generation for circular economy and reduction of environmental impacts, it is important to evaluate the factors leading to constraints regarding waste. Previous researchers have assessed construction company attitudes and behaviors toward CDW management, but factors such as the presence of environmental technicians, registration of the CDW generated, commitment to the legal framework, the subcontracting regime, and construction works' oversight were rarely addressed in terms of the differences existing within the construction sector. Thus, the objective of this research is to evaluate the relationship of these factors with construction company size. A questionnaire was sent to Portuguese construction companies, and 652 responded. The sample was divided into three groups: micro, small, and medium/large companies. Statistical data treatment was carried out to assess whether there were statistically significant differences in the mentioned factors between groups. The main conclusions highlight: the prevalence of environmental technicians working in larger companies; the registration on waste platforms being only performed consistently by medium/large companies; a considerable proportion of micro and small companies having knowledge gaps about the practices adopted; the responsibility for CDW management within the subcontracting regime being mainly from subcontractors; and the presence of a gap regarding onsite construction works oversight. These differences lead to the need to reevaluate the strategies for CDW management and adapt the strategies to the specific conditions of the construction sector, including the size of construction companies.

Utility of Routine EEG in Emergency Department and Inpatient Service.

OBJECTIVE: The most important indication for EEGs is the investigation of epileptic and nonepileptic seizures. However, it is unclear whether EEG in the emergency depatment (ED) can be useful in managing other conditions. Our objective was to investigate the usefulness of EEGs in the ED. METHODS: We performed an observational, descriptive, retrospective study based on clinical records between 2018 and 2019. We evaluated patients admitted to our ED or hospital wards who underwent an EEG. We defined the EEG results as useful when they prompted changes in antiepileptic drug (AED) treatment or clinical management. RESULTS: We gathered information from 236 patients with a mean age of 59.23 years (SD ±22.6), of whom 47.9% were women. In patients with seizures, 18.2% were generalized, 27.1% were focal, and 18.6% were unknown. Overall, 25.8% of the EEGs were abnormal. However, in patients with a history of predisposing conditions for epileptic seizures or encephalopathies, the tracing was abnormal in 47.5%. The most frequent alteration on the abnormal EEGs was generalized slowing (18.2%). The EEG was useful in 76.7% of patients: AEDs changed in 8.4% and clinical management changed in 76.2% of patients. The usefulness of EEGs associated with acute ischemic lesions on CT (p = 0.023) and with the diagnosis of vasovagal syncope (p = 0.022). CONCLUSIONS: Routine EEG is useful in the ED, even in patients with a normal CT or MR brain image, because it helps determine clinical management or AED changes.

Employment of U-Shape Technique at Reentry Surgery for Papillae Coronal Migration on the Rehabilitation of Anterior Single Implant: 3-Year Follow-Up Case Report.

INTRODUCTION: The rehabilitation of a maxillary single dental implant represents a great challenge at clinical practice. Harmony among the implant-supported crown and adjacent teeth is required in which concerns pink and white esthetics. The aim of the present case report is to depict a multidisciplinary treatment in which the U-shape flap technique for papillae preservation at second stage surgery was used. CASE PRESENTATION: One female patient presenting an un-rehabilitated dental implant at the left central incisor position sought treatment at the Centre of Education and Research on Dental Implants (CEPID). Alterations of color, shape, and position were observed on the anterior maxillary teeth. For proper treatment planning, radiograph, wax-up, and mock-up were performed. Second stage surgery was performed by the U-shape flap technique. A trunnion abutment was installed at the implant and a provisional subcontoured cemented crown was manufactured. Dental bleaching, feldspathic veneers, and a ceramic crown were performed. Oral hygiene instructions were recommended. Follow-up appointments were set at 1.5 and 3 years after restoration placement. After 3-year follow-up, soft tissue stability and health were preserved and papillae coronal migration around the single dental implant was observed. A complication-free treatment was reached, and patient demonstrated satisfaction towards esthetic and function. CONCLUSIONS: The use of U-shape technique at second stage surgery associated to adequate prosthetic contour improved soft tissue esthetic outcomes, while the multidisciplinary treatment planning provided adequate solutions, refining harmony between dental and implant-supported components.

Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery.

In this research, we conducted a systematic evaluation of the synthesis parameters of a multi-responsive core-shell nanocomposite (Fe3O4 nanoparticles coated by poly(N-isopropylacrylamide) (PNIPAM) in the presence of chitosan (CS) (Fe3O4@PNIPAM-CS). Scanning electron microscopy (SEM) was used to follow the size and morphology of the nanocomposite. The functionalization and the coating of Fe3O4 nanoparticles (Nps) were evaluated by the ζ-potential evolution and Fourier Transform infrared spectroscopy (FTIR). The nanocomposite exhibited a collapsed structure when the temperature was driven above the lower critical solution temperature (LCST), determined by dynamic light scattering (DLS). The LCST was successfully shifted from 33 to 39 °C, which opens the possibility of using it in physiological systems. A magnetometry test was performed to confirm the superparamagnetic behavior at room temperature. The obtained systems allow the possibility to control specific properties, such as particle size and morphology. Finally, we performed vincristine sulfate loading and release tests. Mathematical analysis reveals a two-stage structural-relaxation release model beyond the LCST. In contrast, a temperature of 25 °C promotes the diffusional release model. As a result, a more in-depth comprehension of the release kinetics was achieved. The synthesis and study of a magnetic core-shell nanoplatform offer a smart material as an alternative targeted release therapy due to its thermomagnetic properties.

Attitudes of pediatric dentists toward parental presence during dental treatment of children.

BACKGROUND: This study was performed to examine the current attitudes of pediatric dentists in the United States toward the presence of parents in the dental operatory during dental treatment for their children. METHODS: E-mail letters were sent to the 1516 American pediatric dentists listed in the directory of the American Academy of Pediatric Dentistry. Respondents were directed to follow a hyperlink provided in the e-mail letter to a website containing survey questions. Answers were directly submitted via the internet into a database supported by the New Jersey Dental School. RESULTS: 905 acceptable surveys were received (60% response rate). Most practitioners (74%) generally allowed parental presence, although a majority (58%) felt that children would be less cooperative in the presence of parents. Initial examination had the highest frequency of parental presence allowed, whereas sedation had the lowest. When practitioners considered whether to allow parental presence, age and behavior were the two most important factors reported. Some demographic factors that had an effect on parental presence policy were region of the country (more parental presence was allowed in the Northeast and West), area of practice (more parental presence was allowed in suburban or urban areas), and type of practice (solo practitioners were more likely to exclude parents). Most practitioners reported a recent change to allow more parental presence because of changes in the expectation of parents (67%), and legal issues (66%). CONCLUSIONS: Most American pediatric dentists allow parents in the dental operatory most of the time that children receive dental treatment. CLINICAL IMPLICATIONS: Practitioners might wish to follow the findings of this study and allow parents into the treatment operatory whenever children receive dental treatment.

An innovative method to reduce oil waste using a sensor made of recycled material to evaluate engine oil life in automotive workshops.

In this work, a capacitive sensor made of recycled material is proposed to monitor oil quality in automotive workshops in order to reduce the waste of useful lubricant oil caused by shorter periods of use than those established by the manufacturers. The sensor was fabricated from a recycled aluminum heat sink and used to measure the permittivity of oil samples. The proposed method was compared with Fourier-transform infrared spectroscopy analysis to evaluate degradation parameters, as described in standard practice ASTM E-2412. The obtained results showed good agreement between both techniques, validating the use of the proposed sensor to evaluate oil condition. The use of permittivity measurements could be used to evaluate oil quality in an easier, faster, and economical way compared with other laboratory tests.

Coronary ostial eccentricity in severe aortic stenosis: Guidance for BASILICA transcatheter leaflet laceration.

BACKGROUND: Eccentricity of coronary ostial positions in relation to the aortic valve cusp may influence the target laceration location in BASILICA (Bioprosthetic or native Aortic Scallop Intentional Laceration to prevent Coronary Artery obstruction). Eccentricity of the coronary ostia in relation to coronary cusps of native and valve-in-valve transcatheter aortic valve replacement (TAVR) was not well described before. METHODS: A total of 121 pre-TAVR patients' CT data (72 native valves TAVR and 49 bioprosthetic surgical valves TAVR) was included and coronary ostial eccentricity angles were measured and compared. Coronary ostial angles were measured between mid-cusp line to coronary ostium in CT perpendicular images. RESULTS: In the overall cohort, the right coronary artery (RCA) had an eccentric origin in the majority of cases, favoring the commissure between the right and the non coronary cusp (17.0°, IQR; 10-25). On the other hand, the left coronary artery (LCA) originated most commonly near center of the cusp position (0°, IQR; -8 -7.5) In comparison of native and bioprosthetic valves, RCA ostial angles were more eccentric in native valves (19.0°, IQR; 12-26) than in bioprosthetic valves (14.0°, IQR; 3-20) (p = 0.004). Whereas, LCA ostial angle has no significant differences between native valves (-2.0°, IQR;-7.75-5.75) and bioprosthetic valves (1°, IQR;-8-13), (p = 0.6). CONCLUSION: RCA ostia often have an eccentric origin towards the non-coronary cusp, especially in native aortic valves, while LCA ostia commonly originate near the center of the cusp. This finding may contribute to better performance of BASILICA procedures.