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1.
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.
Bioorg Med Chem Lett
; 50: 128335, 2021 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34425201
2.
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Bioorg Med Chem Lett
; 29(7): 905-911, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30732944
3.
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.
Toxicol Appl Pharmacol
; 338: 204-213, 2018 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29146462
4.
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Bioorg Med Chem Lett
; 27(13): 2974-2981, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28512031
5.
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 3: an increase in aqueous solubility via the disruption of crystal packing.
Bioorg Med Chem Lett
; 22(2): 912-5, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22209462
6.
Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications.
J Nanosci Nanotechnol
; 12(10): 7993-8000, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23421169
7.
Evaluation of drug load and polymer by using a 96-well plate vacuum dry system for amorphous solid dispersion drug delivery.
AAPS PharmSciTech
; 13(2): 713-22, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22562615
8.
Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process.
Xenobiotica
; 41(12): 1076-87, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21864203
9.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem
; 64(16): 11841-11856, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34251202
10.
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
ACS Med Chem Lett
; 11(3): 327-333, 2020 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32184965
11.
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
ACS Med Chem Lett
; 11(6): 1342-1347, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551022
12.
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.
J Med Chem
; 62(13): 6223-6240, 2019 07 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31082230
13.
Solubilization of a Poorly Soluble B-Raf (Rapidly Accelerated Fibrosarcoma) Inhibitor: From Theory to Application.
J Pharm Sci
; 107(1): 327-333, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28989016
14.
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
J Med Chem
; 50(12): 2767-78, 2007 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-17488003
15.
Compatibility study of a parenteral microdose polyethylene glycol formulation in medical devices and identification of degradation impurity by 2D-LC/MS.
J Pharm Biomed Anal
; 137: 182-188, 2017 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28131057
16.
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J Med Chem
; 60(22): 9162-9183, 2017 11 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28892380
17.
7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.
J Med Chem
; 49(17): 5352-62, 2006 Aug 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-16913725
18.
Solubilization and preformulation studies on PG-300995 (an anti-HIV drug).
J Pharm Sci
; 94(2): 297-303, 2005 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-15570598
19.
Prediction of the aqueous solubility: comparison of the general solubility equation and the method using an amended solvation energy relationship.
J Pharm Sci
; 91(2): 517-33, 2002 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-11835210
20.
Estimation of aqueous solubility of organic compounds by using the general solubility equation.
Chemosphere
; 48(5): 487-509, 2002 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-12146628