A comparative 18F-FDG and an anti-PD-L1 probe PET/CT imaging of implant-associated Staphylococcus aureus osteomyelitis.

Background: Early and accurate diagnosis of infection-induced osteomyelitis, which often involves increased PD-L1 expression, is crucial for better treatment outcomes. Radiolabeled anti-PD-L1 nuclear imaging allows for sensitive and non-invasive whole-body assessments of PD-L1 expression. This study aimed to compare the efficacy of 18F-FDG and an 18F-labeled PD-L1-binding peptide probe (18F-PD-L1P) in PET imaging of implant-associated Staphylococcus aureus osteomyelitis (IAOM). Methods: In this study, we synthesized an anti-PD-L1 probe and compared its efficacy with 18F-FDG and 18F-PD-L1P in PET imaging of implant-associated Staphylococcus aureus osteomyelitis (IAOM). The %ID/g ratios (i.e., radioactivity ratios between the infected and non-infected sides) of both probes were evaluated for sensitivity and accuracy in post-infected 7-day tibias and post-infected 21 days, and the intensity of 18F-PD-L1P uptake was compared with pathological changes measured by PD-L1 immunohistochemistry (IHC). Results: Compared with 18F-FDG, 18F-PDL1P demonstrated higher %ID/g ratios for both post-infected 7-day tibias (P=0.001) and post-infected 21 days (P=0.028). The intensity of 18F-PD-L1P uptake reflected the pathological changes of osteomyelitic bones. In comparison to 18F-FDG, 18F-PDL1P provides earlier and more sensitive detection of osteomyelitis caused by S. aureus. Conclusion: Our findings suggest that the 18F-PDL1P probe is a promising tool for the early and accurate detection of osteomyelitis caused by S. aureus.

Can Physical Exercise Improve the Residents' Health?

With the rapid development of China's economy and society, the quality of life of residents has continued to improve, and the concept of health has gradually taken root in the hearts of the people. This paper uses the 2018 data of the China Family Panel Studies (CFPS) to analyze the internal mechanism and influencing factors of participating in physical exercise on the health level of residents. The results show that participating in physical exercise can significantly improve the subjective and objective health level of residents, and the result passed two important robustness tests. Heterogeneous test shows that the degree of influence of participation in physical exercise on the health level of residents varies according to the different regional and individual characteristics; the effect of urban residents' physical exercise to improve their health level is better than that of rural residents; and the effect of physical exercise on the improvement of health level is more obvious in the eastern and western areas, those who have not completed compulsory education, and those with high incomes. This study will have strong guiding significance for the improvement of the overall level of national health in China and will provide a theoretical basis and guiding opinions for the construction of healthy China.