Automatic and controlled attentional orienting toward emotional faces in patients with Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative motor disorder that can associate with deficits in cognitive and emotional processing. In particular, PD has been reported to be mainly associated with defects in executive control and orienting attentional systems. The deficit in emotional processing mainly emerged in facial expression recognition. It is possible that the defects in emotional processing in PD may be secondary to other cognitive impairments, such as attentional deficits. This study was designed to systematically investigate the different weight of automatic and controlled attentional orienting mechanisms implied in emotional selective attention in PD. To address our purpose, we assessed drug-naïve PD patients and age-matched healthy controls with two dot-probe tasks that differed for stimuli duration. Automatic and controlled attentions were evaluated with stimuli lasting 100 ms and 500 ms, respectively. Furthermore, we introduced an emotion recognition task to investigate the performance in explicit emotion classification. The stimuli used in both the tasks dot-probe and emotion recognition were expressive faces displaying neutral, disgusted, fearful, and happy expressions.Our results showed that in PD patients, compared with healthy controls, there was 1) an alteration of automatic and controlled attentional orienting toward emotional faces in both the dot-probe tasks (with short and long durations), and 2) no difference in the emotion recognition task. These findings suggest that, from the early stages of the disease, PD can yield specific deficits in implicit emotion processing task (i.e., dot-probe task) despite a normal performance in explicit tasks that demand overt emotion recognition.

False memories formation is increased in individuals with insomnia.

Previous studies suggest that sleep can influence false memories formation. Specifically, acute sleep loss has been shown to promote false memories production by impairing memory retrieval at subsequent testing. Surprisingly, the relationship between sleep and false memories has only been investigated in healthy subjects but not in individuals with insomnia, whose sleep is objectively impaired compared to healthy subjects. Indeed, this population shows several cognitive impairments involving prefrontal functioning that could affect source monitoring processes and contribute to false memories generation. Moreover, it has been previously reported that subjects with insomnia differentially process sleep-related versus neutral stimuli. Therefore, the aim of the present study was to compare false memories production between individuals with insomnia symptoms and good sleepers, and to evaluate the possible influence of stimulus category (neutral versus sleep-related) in the two groups. The results show that false memories are globally increased in participants reporting insomnia symptoms compared to good sleepers. A reduction in source monitoring ability was also observed in the former group, suggesting that an impairment of this executive function could be especially involved in false memories formation. Moreover, our data seem to confirm that false memories production in individuals with insomnia symptoms appears significantly modulated by stimulus category.

Time perception impairment in early-to-moderate stages of Huntington's disease is related to memory deficits.

Huntington's disease (HD) primarily affects striatum and prefrontal dopaminergic circuits which are fundamental neural correlates of the timekeeping mechanism. The few studies on HD mainly investigated motor timing performance in second durations. The present work explored time perception in early-to-moderate symptomatic HD patients for seconds and milliseconds with the aim to clarify which component of the scalar expectancy theory (SET) is mainly responsible for HD timing defect. Eleven HD patients were compared to 11 controls employing two separate temporal bisection tasks in second and millisecond ranges. Our results revealed the same time perception deficits for seconds and milliseconds in HD patients. Time perception impairment in early-to-moderate stages of Huntington's disease is related to memory deficits. Furthermore, both the non-systematical defect of temporal sensitivity and the main impairment of timing performance in the extreme value of the psychophysical curves suggested an HD deficit in the memory component of the SET. This result was further confirmed by the significant correlations between time perception performance and long-term memory test scores. Our findings added important preliminary data for both a deeper comprehension of HD time-keeping deficits and possible implications on neuro-rehabilitation practices.

Callous-Unemotional Traits and Emotion Perception Accuracy and Bias in Youths.

This study investigated the associations among conduct problems, callous-unemotional (CU) traits, and indices of emotion recognition accuracy and emotion recognition bias obtained from human faces. Impairments in emotion recognition were considered within broader, impaired emotional and social functioning. The sample consisted of 293 middle-school students (51.19% girls; M age = 12.97 years, SD = 0.88 years). In general, CU traits were associated with less accuracy in recognizing emotions, especially fearful and angry faces, and such deficits in emotional recognition were not associated with conduct problems independent of CU traits. These results support the importance of studying potential deficits in the recognition of emotions other than fear. Furthermore, our results support the importance of considering the role of CU traits when studying emotional correlates of conduct problems. For children scoring high on CU traits, the emotion recognition accuracy of anger was low irrespective of the level of conduct problems, whereas in children scoring low on CU traits, less accuracy in recognizing emotions was related to increases in conduct problems. Finally, our results support the need for research to not only focus on accuracy of emotional recognition but also test whether there are specific biases leading to these inaccuracies. Specifically, CU traits were associated not only with lower accuracy in recognizing fearful faces but also with a tendency to interpret fearful faces as angry. This suggests that the emotional deficit associated with CU traits is not just a deficit in empathic concern toward others distress but also includes a tendency to overinterpret emotions as potential threats to oneself.

How the Effect of Virtual Reality on Cognitive Functioning Is Modulated by Gender Differences.

Virtual reality (VR) can be a promising tool to simulate reality in various settings but the real impact of this technology on the human mental system is still unclear as to how VR might (if at all) interfere with cognitive functioning. Using a computer, we can concentrate, enter a state of flow, and still maintain control over our surrounding world. Differently, VR is a very immersive experience which could be a challenge for our ability to allocate divided attention to the environment to perform executive functioning tasks. This may also have a different impact on women and men since gender differences in both executive functioning and the immersivity experience have been referred to by the literature. The present study aims to investigate cognitive multitasking performance as a function of (1) virtual reality and computer administration and (2) gender differences. To explore this issue, subjects were asked to perform simultaneous tasks (span forward and backward, logical-arithmetic reasoning, and visuospatial reasoning) in virtual reality via a head-mounted display system (HDMS) and on a personal computer (PC). Our results showed in virtual reality an overall impairment of executive functioning but a better performance of women, compared to men, in visuospatial reasoning. These findings are consistent with previous studies showing a detrimental effect of virtual reality on cognitive functioning.

Interplay among Anxiety, Digital Environmental Exposure, and Cognitive Control: Implications of Natural Settings.

Inhibitory control performance may differ greatly as a function of individual differences such as anxiety. Nonetheless, how cognitive control proficiency might be influenced by exposure to various environments and how anxiety traits might impact these effects remain unexplored. A cohort of thirty healthy volunteers participated in the study. Participants performed a Go/No-Go task before exposure to a 'forest' and 'urban' virtual environment, in a counterbalanced design, before repeating the GNG task. The State-Trait Anxiety Inventory (STAI) was finally filled-in. Our findings unveiled an initial negative correlation between anxiety trait levels and GNG task performance, consistent with the established literature attributing difficulties in inhibitory functionality to anxiety. Additionally, different environmental exposures reported opposite trends. Exposure to the 'forest' environment distinctly improved the GNG performance in relation to anxiety traits, while the 'urban' setting demonstrated adverse effects on task performance. These results underscore the intricate relationship among cognitive control, environmental exposure, and trait anxiety. In particular, our findings highlight the potential of natural settings, such as forests, to mitigate the impact of anxiety on inhibition. This might have implications for interventions aimed at improving cognitive control.

Intuitive thinking predicts false memory formation due to a decrease in inhibitory efficiency.

False memory formation is usually studied using the Deese-Roediger-McDermott paradigm (DRM), in which individuals incorrectly remember words that were not originally presented. In this paper, we systematically investigated how two modes of thinking (analytical vs. intuitive) can influence the tendency to create false memories. The increased propensity of intuitive thinkers to generate more false memories can be explained by one or both of the following hypotheses: a decrease in the inhibition of the lure words that come to mind, or an increased reliance on the familiarity heuristic to determine if the word has been previously studied. In two studies, we conducted tests of both recognition and recall using the DRM paradigm. Our observations indicate that a decrease in inhibitory efficiency plays a larger role in false memory formation compared to the use of the familiarity heuristic.

Anxiety is not the right choice! Individual differences in trait anxiety modulate biases in pseudoneglect.

Pseudoneglect, the tendency to display a leftward perceptual bias, is consistently observed in line bisection tasks. Some studies have shown that pseudoneglect is sensitive to emotions. This emotion-related modulation is likely related to valence-dependent hemispheric lateralization, although the results do not converge. A possible explanation for these inconsistencies could be individual differences in emotional tone. Considering that negative and positive emotions produce different basic activations of the two hemispheres, emotional characteristics of the subjects, such as trait anxiety, could in fact modulate the pseudoneglect phenomenon. To verify this, high- and low-anxiety participants were asked to centrally bisect horizontal lines delimited by neutral or emotional (happy and sad) faces. In line with previous studies, results here showed a decrease in the leftward bisection error in the presence of happy faces, indicating a greater involvement of the left hemisphere in processing positive emotional stimuli. In addition, trait anxiety influenced the magnitude of the visual bias. High-anxiety subjects, compared to low-anxiety subjects, showed a general bias in visual attention toward the left space as a function of emotional valence. Results are discussed within the framework of valence-dependent hemispheric specialization and the relative degree of activation. In sum, our data highlight the relevance of considering emotional individual differences in studying the pseudoneglect phenomenon.

Alpha waves: a neural signature of visual suppression.

Alpha waves are traditionally considered a passive consequence of the lack of stimulation of sensory areas. However, recent results have challenged this view by showing a modulation of alpha activity in cortical areas representing unattended information during active tasks. These data have led us to think that alpha waves would support a 'gating function' on sensorial stimulation that actively inhibits unattended information in attentional tasks. Visual suppression occurring during a saccade and blink entails an inhibition of incoming visual information, and it seems to occur at an early processing stage. In this study, we hypothesized that the neural mechanism through which the visual system exerts this inhibition is the active imposition of alpha oscillations in the occipital cortex, which in turn predicts an increment of alpha amplitude during a visual suppression phenomena. We measured visual suppression occurring during short closures of the eyelids, a situation well suited for EEG recordings and stimulated the retinae with an intra-oral light administered through the palate. In the behavioral experiment, detection thresholds were measured with eyes steady open and steady closed, showing a reduction of sensitivity in the latter case. In the EEG recordings performed under identical conditions we found stronger alpha activity with closed eyes. Since the stimulation does not depend on whether the eyes were open or closed, we reasoned that this should be a central effect, probably due to a functional role of alpha oscillation in agreement with the 'gating function' theory.

Comparative Study of the Restorative Effects of Forest and Urban Videos during COVID-19 Lockdown: Intrinsic and Benchmark Values.

The prolonged lockdown imposed to contain the COrona VIrus Disease 19 COVID-19 pandemic prevented many people from direct contact with nature and greenspaces, raising alarms for a possible worsening of mental health. This study investigated the effectiveness of a simple and affordable remedy for improving psychological well-being, based on audio-visual stimuli brought by a short computer video showing forest environments, with an urban video as a control. Randomly selected participants were assigned the forest or urban video, to look at and listen to early in the morning, and questionnaires to fill out. In particular, the State-Trait Anxiety Inventory (STAI) Form Y collected in baseline condition and at the end of the study and the Part II of the Sheehan Patient Rated Anxiety Scale (SPRAS) collected every day immediately before and after watching the video. The virtual exposure to forest environments showed effective to reduce perceived anxiety levels in people forced by lockdown in limited spaces and environmental deprivation. Although significant, the effects were observed only in the short term, highlighting the limitation of the virtual experiences. The reported effects might also represent a benchmark to disentangle the determinants of health effects due to real forest experiences, for example, the inhalation of biogenic volatile organic compounds (BVOC).

Validation of a low-cost EEG device in detecting neural correlates of social conformity.

The study of conformity from a neurobiological point of view has interested many authors: among them, Shestakova and colleagues (2013) have showed how conformity can be assessed through the analysis of event related potentials (ERPs). More specifically, the P300 component of the ERP was shown to be sensitive to the behavioral adjustment that an individual makes when not agreeing with the majority of a group. Starting from these contributions, in the present study, the famous experiment of Solomon Asch [1] was replicated online. The experiment was conducted on a sample of university students, using an innovative and low-cost tool capable of recording the brain signal (a wireless headset equipped with fourteen electrodes, called Emotiv EPOC). The present research aims to demonstrate how cheap and little sensitive tools enable the detection of ERP components that characterize social conformity in an ecological context.

Visual recognition memory in Alzheimer's disease: repetition-lag effects.

There is considerable evidence that visual recognition memory is largely affected by Alzheimer's disease (AD). Deficits might concern the forming, maintaining, and matching of the memory representation of the visual stimulus, especially when long interitem lags occur. The aim of the present study was to assess the effect of repetition lag on picture identification in mild- and moderate-AD patients, as well as in elderly controls. Participants underwent an old/new paradigm. To manipulate the temporal gradient, short and long lags were introduced between the first and second presentations. Pictures were presented at different levels of spatial filtering, following a coarse-to-fine order. This allowed for the measurement of the amount of physical information required for the identification of stimuli as a function of prior exposure and repetition lag. In the elderly, the magnitude of repetition priming did not differ as a function of interitem lag. Instead, repetition-lag effects interacted with dementia severity, and the capacity to retain memory traces for longer intervals worsened as the disease progresses. Current findings suggest that severe cortical degeneration may render AD patients unable to maintain their perceptual memories, and that dementia severity is a critical variable in the visual recognition memory assessment.

Attentional Orienting to Emotional Faces Moderates the Association Between Callous-Unemotional Traits and Peer-Nominated Aggression in Young Adolescent School Children.

Callous-unemotional (CU) traits are associated with aggressive behavior but preliminary research suggests this relationship is modified by patterns of emotional processing. This study examined whether attentional orienting to emotional faces moderated the association between CU traits and peer-nominated aggression in 251 middle school students (53% females, mean age = 13.24 years, SD = 0.73). Attentional orienting was assessed using an emotional faces (i.e., angry, fearful, happy, sad, and neutral) variant of the dot-probe task. Students also completed a self-report measure of CU traits and their classmates made peer nominations of aggression. Logistic regression analyses showed that peer-nominated aggression was positively related to CU traits at low levels of attentional orienting to angry faces, whereas aggression was unrelated to CU traits at high levels of attentional orienting to angry faces. That is, peer-nominated aggression was greatest for youth high on CU traits who were not engaged by angry faces. These findings support the importance of considering different patterns of emotional responding when studying the association between CU traits and aggressive behavior in youth.

Category-specific visual identification of filtered objects in Alzheimer's disease.

The category-specific deficit in object identification as function of spatial frequency (SF) content and priming effect was investigated. Twenty-two patients with Alzheimer Disease (AD) and 24 control subjects performed an object identification task. The objects belonged to living and nonliving categories. In the study phase an episodic trace of objects was created. In the identification phase, each object was revealed in a sequence of frames wherein the object was represented by an increasingly less and less filtered image up to complete version. A recall phase followed immediately after the identification phase. While the priming was preserved in mild-AD but not in moderate-AD, no difference was observed in the recall task. Moreover, although patients showed a decline in performance for both categories compared to controls, this decline was more rapid for living things especially in patients with more severe disease. Present results indicate a semantic memory deficit along with a disruption of perceptual representation. Data were discussed referring to perceptual/functional, domain-specific knowledge, and prefrontal cortex (PFC) theories.

Category-specific visual recognition as affected by aging and expertise.

The influence of aging and expertise on visual identification as function of semantic category (animals and tools) and spatial-frequency content of stimuli was investigated. Three-age groups of experts (whose profession required the use of manipulable tools) and non-experts, participated to the experiment. Data showed a different involvement of low and high spatial-frequency channels in processing objects semantically different: animals were identified at a coarse spatial scale (low spatial frequencies) and tools at a finer spatial scale (higher spatial frequencies). A gradual age-related decline in the identification for both categories (more physical information was required as the age increased) was found in non-experts, while in experts a similar trend was found only for animals and not for tools. In fact, independently on the age, experts could identify tools without requiring more visual details, probably for the benefits from their long-term experience with tools. Expertise, represented at higher levels of cognitive processing, might compensate the loss of lower levels of information processing due to aging.

Emotional contexts modulate intentional memory suppression of neutral faces: Insights from ERPs.

The main goal of present work is to gain new insight into the temporal dynamics underlying the voluntary memory control for neutral faces associated with neutral, positive and negative contexts. A directed forgetting (DF) procedure was used during the recording of EEG to answer the question whether is it possible to forget a face that has been encoded within a particular emotional context. A face-scene phase in which a neutral face was showed in a neutral or emotional scene (positive, negative) was followed by the voluntary memory cue (cue phase) indicating whether the face had to-be remember or to-be-forgotten (TBR and TBF). Memory for faces was then assessed with an old/new recognition task. Behaviorally, we found that it is harder to suppress faces-in-positive-scenes compared to faces-in-negative and neutral-scenes. The temporal information obtained by the ERPs showed: 1) during the face-scene phase, the Late Positive Potential (LPP), which indexes motivated emotional attention, was larger for faces-in-negative-scenes compared to faces-in-neutral-scenes. 2) Remarkably, during the cue phase, ERPs were significantly modulated by the emotional contexts. Faces-in-neutral scenes showed an ERP pattern that has been typically associated to DF effect whereas faces-in-positive-scenes elicited the reverse ERP pattern. Faces-in-negative scenes did not show differences in the DF-related neural activities but larger N1 amplitude for TBF vs. TBR faces may index early attentional deployment. These results support the hypothesis that the pleasantness or unpleasantness of the contexts (through attentional broadening and narrowing mechanisms, respectively) may modulate the effectiveness of intentional memory suppression for neutral information.

You are that smiling guy I met at the party! Socially positive signals foster memory for identities and contexts.

The emotional influence of facial expressions on memory is well-known whereas the influence of emotional contextual information on memory for emotional faces is yet to be extensively explored. This study investigated the interplay between facial expression and the emotional surrounding context in affecting both memory for identities (item memory) and memory for associative backgrounds (source memory). At the encoding fearful and happy faces were presented embedded in fear or happy scenes (i.e.: fearful faces in fear-scenes, happy faces in happy-scenes, fearful faces in happy-scenes and happy faces in fear-scenes) and participants were asked to judge the emotional congruency of the face-scene compounds (i.e. fearful faces in fear-scenes and happy faces in happy-scenes were congruent compounds). In the recognition phase, the old faces were intermixed with the new ones: all the faces were presented isolated with a neutral expression. Participants were requested to indicate whether each face had been previously presented (item memory). Then, for each old face the memory for the scene originally compounded with the face was tested by a three alternative forced choice recognition task (source memory). The results evidenced that face identity memory is differently modulated by the valence in congruent face-context compounds with better identity recognition (item memory) for happy faces encoded in happy-scenarios. Moreover, also the memory for the surrounding context (source memory) benefits from the association with a smiling face. Our findings highlight that socially positive signals conveyed by smiling faces may prompt memory for identity and context.

Hemispheric asymmetry for spatially filtered stimuli belonging to different semantic categories.

The hemispheric specialization for processing visual stimuli as a function of spatial-frequency content and semantic category was investigated. Spatially filtered pictures of animals and tools were displayed to both hemifields at nine levels of spatial-frequency filtering following a coarse-to-fine design. Results showed a differential hemispheric specialization in relation to the semantic category of stimuli. Animals might be identified at low spatial frequencies (coarse information) in a similar extent in both hemifield conditions, while a hemispheric dissociation was found for tools (the increasing of levels of high-spatial frequency information was especially needed when such stimuli were presented to the left visual field /right hemisphere (RH) relative to that for right visual field/left hemisphere presentations).

A new standardized set of ecological pictures for experimental and clinical research on visual object processing.

A new set of 174 pictures in black-and-white, coloured and spatially filtered versions, taken from photographs of real objects belonging to different semantic categories, was realised for experimental and clinical research on visual object processing. Two samples, one of English speakers and one of Italian speakers, were tested in order to provide the normative data for each picture, in both black-and-white and coloured versions, in relation to familiarity, visual complexity and name agreement.

Attractiveness and affordance shape tools neural coding: insight from ERPs.

The relation between attractiveness and motor affordance is a key topic in design and has not yet been investigated electrophysiologically. In this respect, action affordance and attractiveness represent two crucial dimensions in object processing (specifically for tools). In light of this evidence, Event Related Potentials (ERPs) enabled us to gain new insights into the time course of the interaction between these two dimensions during an explicit tool evaluation task. Behaviorally, tools that were judged as high affording and high attractive yielded faster response times than those judged as low affording and low attractive. The ERP results showed that early processes related to sensory gating and feature extraction (N100) were sensitive to both affordance and attractiveness; the P200 was dominated by affordance, indexing a facilitated access to motor action representation. The N300, P300 and the Late Positive Potential (LPP) showed enhanced responses for highly affording/attractive tools, reflecting the interconnection between attractiveness and affordance. Later responses were entirely affected by attractiveness, suggesting additional affective responses evoked by desirable tools. We are showing that things that are perceived as more functional and attractive have a privileged neural activation in the time course of tool evaluation, for the first time.