Detalles de la búsqueda
1.
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor: SAR investigation around PNU-120596.
Bioorg Med Chem Lett
; 93: 129433, 2023 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37557923
2.
High integrin αVß6 affinity reached by hybrid domain deletion slows ligand-binding on-rate.
Proc Natl Acad Sci U S A
; 115(7): E1429-E1436, 2018 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-29378937
3.
Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network.
Bioorg Med Chem
; 24(16): 3513-20, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27297999
4.
Discovery of a novel Kv7 channel opener as a treatment for epilepsy.
Bioorg Med Chem Lett
; 25(21): 4941-4944, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25987375
5.
Affinity purification of a chimeric nicotinic acetylcholine receptor in the agonist and antagonist bound states.
Protein Expr Purif
; 79(1): 102-10, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21664975
6.
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
Bioorg Med Chem Lett
; 19(9): 2524-9, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19328692
7.
3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
Bioorg Med Chem Lett
; 18(20): 5493-6, 2008 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18812259
8.
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
Bioorg Med Chem Lett
; 18(12): 3611-5, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18490160
9.
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
J Med Chem
; 61(7): 3008-3026, 2018 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29498843
10.
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
J Med Chem
; 61(10): 4476-4504, 2018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29613789
11.
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.
J Med Chem
; 60(23): 9860-9873, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29148769
12.
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
J Med Chem
; 49(14): 4425-36, 2006 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-16821801
13.
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.
J Med Chem
; 48(4): 905-8, 2005 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15715459
14.
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
J Med Chem
; 58(7): 3223-52, 2015 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25781223
15.
Two-Dimensional NMR Analysis of Acetonide Derivatives in the Stereochemical Assignment of Polyol Chains: The Absolute Configurations of Dermostatins A and B.
J Org Chem
; 62(9): 2925-2934, 1997 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-11671656
16.
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
J Med Chem
; 57(3): 861-77, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24392688
17.
1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.
J Med Chem
; 54(6): 1724-39, 2011 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21366332
18.
Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.
Curr Pharm Des
; 16(5): 538-54, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-19909231
19.
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
J Med Chem
; 53(3): 1222-37, 2010 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20043678
20.
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem
; 14(24): 8219-48, 2006 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17011782