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Biochim Biophys Acta Biomembr ; 1865(3): 184114, 2023 03.
Artículo en Inglés | MEDLINE | ID: mdl-36581017

RESUMEN

The fluid mosaic model proposed by Singer and Nicolson established a powerful framework to interrogate biological membranes that has stood the test of time. They proposed that the membrane is a simple fluid, meaning that proteins and lipids are randomly distributed over distances larger than those dictated by direct interactions. Here we present an update to this model that describes a spatially adaptable fluid membrane capable of tuning local composition in response to forces originating outside the membrane plane. This revision is rooted in the thermodynamics of lipid mixtures, draws from recent experimental results, and suggests new modes of membrane function.


Asunto(s)
Lípidos de la Membrana , Proteínas de la Membrana , Lípidos de la Membrana/metabolismo , Proteínas de la Membrana/metabolismo , Modelos Biológicos , Membrana Celular/metabolismo
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