Detalles de la búsqueda
1.
Generation and characterization of functional phosphoserine-incorporated neuronal nitric oxide synthase holoenzyme.
J Biol Inorg Chem
; 24(1): 1-9, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30315355
2.
Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
J Biol Chem
; 291(39): 20487-502, 2016 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27496950
3.
Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance.
J Biol Chem
; 289(19): 13273-83, 2014 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24648521
4.
Oxidative stress induces phosphorylation of neuronal NOS in cardiomyocytes through AMP-activated protein kinase (AMPK).
Biochem Biophys Res Commun
; 459(3): 393-7, 2015 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25732085
5.
Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance.
J Phys Chem A
; 119(25): 6641-9, 2015 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26035438
6.
Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transfer.
J Struct Biol
; 188(1): 46-54, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25175399
7.
Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species.
J Biol Chem
; 288(40): 28668-86, 2013 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23940049
8.
Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.
Bioorg Med Chem Lett
; 24(18): 4504-4510, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25149509
9.
Methylated N(ω)-hydroxy-L-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction.
Biochemistry
; 52(18): 3062-73, 2013 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23586781
10.
Neuronal nitric oxide synthase is phosphorylated in response to insulin stimulation in skeletal muscle.
Biochem Biophys Res Commun
; 435(3): 501-5, 2013 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23680665
11.
Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.
Arch Biochem Biophys
; 533(1-2): 88-94, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23507581
12.
Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett
; 23(20): 5674-9, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23993333
13.
In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg Med Chem
; 21(17): 5323-31, 2013 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23867386
14.
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg Med Chem
; 21(5): 1333-43, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23352768
15.
Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
J Am Chem Soc
; 134(28): 11559-72, 2012 Jul 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-22731813
16.
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.
Bioorg Med Chem
; 20(7): 2435-43, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22370337
17.
Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase.
J Am Chem Soc
; 132(40): 14229-38, 2010 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-20843082
18.
Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J Am Chem Soc
; 132(2): 798-806, 2010 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-20014790
19.
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
Ann Neurol
; 65(2): 209-17, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19235180
20.
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Bioorg Med Chem Lett
; 20(21): 6258-61, 2010 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20833542