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1.
Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies.
Bioorg Med Chem Lett
; 25(20): 4412-8, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26386604
2.
Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup.
Bioorg Med Chem Lett
; 25(14): 2793-9, 2015 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26022839
3.
Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders.
J Med Chem
; 66(18): 13135-13147, 2023 09 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37724542
4.
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.
J Med Chem
; 64(19): 14773-14792, 2021 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34613725
5.
Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.
J Med Chem
; 59(19): 8848-8858, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27564419
6.
Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.
J Med Chem
; 57(18): 7509-22, 2014 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-25165888
7.
Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats.
Obesity (Silver Spring)
; 20(8): 1645-52, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22402735
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