Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly.

The purpose of this study was to examine whether cardiovascular fitness, independent of confounding factors, was associated with immune responsiveness to clinically relevant challenges in older adults (60-76 yr). Thirteen sedentary, low-fit (LF; maximal O(2) uptake = 21.1 +/- 1.1 ml.kg(-1).min(-1)) and 13 physically active, high-fit (HF; maximal O(2) uptake = 46.8 +/- 3.4 ml.kg(-1).min(-1)) older adults participated in this study. Dietary intake was assessed, and a battery of psychosocial tests was administered. In vivo antibody and ex vivo proliferative and cytokine responses to influenza (Fluzone) and tetanus toxoid (TT) vaccination and delayed-type hypersensitivity skin tests were performed. HF elderly individuals displayed a higher antibody response to two of the three strains included in the Fluzone vaccine as measured by hemagluttination inhibition, but there was no difference between groups in influenza-specific ex vivo proliferation or IFN-gamma or IL-10 production. HF elderly individuals exhibited a lower IgG(1) response and a tendency for a higher IgG(2) response to the TT vaccine. There were, however, no differences in TT-specific ex vivo proliferation or IFN-gamma or IL-10 production. In contrast, HF subjects had higher proliferative responses to phytohemagluttinin. In addition, there were no differences in delayed-type hypersensitivity responses to fungal antigens between groups. These results suggest that, after accounting for confounding factors, HF elderly individuals have higher antibody responses to Fluzone vaccine and a Th2 skewing of the antibody response to TT. There was little evidence that HF mounted better cell-mediated immune responses to the Fluzone or TT vaccine measured in peripheral blood cells or to other recall antigens in vivo.

Ultrasound of the calcaneus and bone mineral density differs in older black and white women but is not impacted by current physical activity.

Black women have lower fracture rates, primarily due to bone-dependent factors; however, the racial differences in quantitative ultrasound (QUS) for older black and white women are poorly characterized, especially in regard to the mediating effects of physical activity. The primary aim of this study was to determine if QUS measures differ in age- and body-size-matched older black and white women and to explore if the racial differences were mediated by differences in current habitual physical activity. We performed dual-energy X-ray absorptiometry (DXA) bone mineral density (BMD) measures and QUS measures [broadband ultrasound attenuation (BUA), speed of sound (SOS), quantitative ultrasound index (QUI)] of the calcaneus in 30 black and 30 white women matched in age (68.3 years) and body mass index (30.0 kg/m2). Black women had greater QUS measures of SOS (1,563.6+/-31.7 vs 1,541.2+/-23.4, p=0.003) and QUI (102.6+/-18.5 vs 90.4+/-15.4, p=0.008), with a strong trend for greater BUA (79.2+/-15.1 vs 71.9+/-15.1 m/sec, p=0.066) compared with white women. As expected, black women had greater BMD measures at all sites; whole body (6.8%, p<0.010), lumbar spine (10.4%, p=0.008), proximal femur (14.2%; p<0.001) and femoral neck (20.3%; p<0.001), compared with white women. Although white women reported expending 45% more energy (p=0.03) in moderate intensity physical activity than black women on a weekly basis, current physical activity did not attenuate the difference in QUS measures between the races. The relations between QUS and BMD measures were similar in black compared with white women. After controlling for BMD, the racial differences in QUS measures were not apparent, precluding the conclusion that bone quality independently contributes to the reduction in fracture risk in older black women. The impact of current physical activity on QUS measures in older black and white women is negligible.