Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells.

Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, (1)H and (13)C NMR). Compound 1 exhibited highest cytotoxicity with 90.16 ± 1.06% inhibition (IC50=5.30 x 10(-4) mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10(-3)mg/ml), while compounds 3 and 4 were inactive in the bioassay.

(5Z)-5-(2-Hy-droxy-benzyl-idene)-3-(4-methyl-phen-yl)-2-sulfanyl-idene-1,3-thia-zolidin-4-one.

In the title compound, C(17)H(13)NO(2)S(2), the dihedral angles between the 2-sulfanyl-idene-1,3-thia-zolidin-4-one group and the pendant toluene and 2-hy-droxy-benzene rings are 74.62 (6) and 8.73 (12)°, respectively. An intra-molecular C-H⋯S inter-action occurs. In the crystal, inversion dimers linked by pairs of O-H⋯O hydrogen bonds generate R(2) (2)(16) loops. This link is reinforced by a pair of C-H⋯O hydrogen bonds. The dimers are connected by weak C-H⋯S inter-actions.

Cyclo-hexa-naminium trichloro-acetate.

In the crystal of the title compound, C(6)H(14)N(+)·C(2)Cl(3)O(2) (-), centrosymmetric assemblies of two cyclo-hexa-naminium cations and two trichloro-acetate ions are linked by N-H⋯O hydrogen bonds, thereby forming R(4) (4)(12) ring motifs. Further N-H⋯O inter-actions link the tetra-mers into chains propagating along the a axis.

The myth of oral hygiene using synthetic mouthwash products.

The synthetic oral cleansing and teeth whitening products like mouthwashes exert adverse effects on teeth, gums and mucous membrane of oral cavity and their extensive use is being criticized. Determining the effect of frequent use of mouthwashes, human cheek cells and their DNA have been studied. Five mouthwash brands were tested and their effects were examined on membrane and DNA of human cheek cells which were found to be very expressive and severe. The DNA, also, received severe damage and breaks developed in its double stranded structure resulting in detachment of small fragments from DNA. The statistical analysis, also, showed significant difference P < 0.005 between the values obtained for DNA double strand breaks for different mouthwashes (and standard mutagen) as compared to untreated control. The study revealed that damage to DNA increases many folds when different mouthwashes are combined. Essential oils of six spice plants (black pepper, clove, black seasam, cinamon, carom seeds and cumin) were evaluated for possessing anti-mutagenic property. These essential oils were found effectively protective against the DNA damaging effect of mouthwashes but could not inhibit it completely. Black pepper, clove, black seasam, cinamon, and cumin were stronger protective as compared to carom seeds.