Detalles de la búsqueda
1.
Pembrolizumab alone or in combination with chemotherapy as first-line therapy for patients with advanced gastric or gastroesophageal junction adenocarcinoma: results from the phase II nonrandomized KEYNOTE-059 study.
Gastric Cancer
; 22(4): 828-837, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30911859
2.
Extending a Systems Model of the APP Pathway: Separation of ß- and γ-Secretase Sequential Cleavage Steps of APP.
J Pharmacol Exp Ther
; 365(3): 507-518, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29563326
3.
First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study.
Lancet Oncol
; 18(11): 1483-1492, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28967485
4.
Systems Pharmacology Analysis of the Amyloid Cascade after ß-Secretase Inhibition Enables the Identification of an Aß42 Oligomer Pool.
J Pharmacol Exp Ther
; 357(1): 205-16, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26826190
5.
A sensitive aß oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.
J Neurosci
; 34(8): 2884-97, 2014 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24553930
6.
CNS amyloid-ß, soluble APP-α and -ß kinetics during BACE inhibition.
J Neurosci
; 34(24): 8336-46, 2014 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-24920637
7.
Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Drug Metab Dispos
; 43(6): 851-63, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25813937
8.
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.
Bioorg Med Chem Lett
; 24(12): 2737-40, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24813734
9.
Pyroglutamate-modified amyloid-ß protein demonstrates similar properties in an Alzheimer's disease familial mutant knock-in mouse and Alzheimer's disease brain.
Neurodegener Dis
; 14(2): 53-66, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24158021
10.
Characterization of plasma ß-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease.
J Neurosci Res
; 90(12): 2247-58, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22987781
11.
Decrease in brain soluble amyloid precursor protein ß (sAPPß) in Alzheimer's disease cortex.
J Neurosci Res
; 89(6): 822-32, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21433051
12.
A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease.
J Appl Lab Med
; 5(1): 15-28, 2020 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31811079
13.
Long-Term Outcomes in KEYNOTE-052: Phase II Study Investigating First-Line Pembrolizumab in Cisplatin-Ineligible Patients With Locally Advanced or Metastatic Urothelial Cancer.
J Clin Oncol
; 38(23): 2658-2666, 2020 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32552471
14.
Clinical Utility of the Combined Positive Score for Programmed Death Ligand-1 Expression and the Approval of Pembrolizumab for Treatment of Gastric Cancer.
Arch Pathol Lab Med
; 143(3): 330-337, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30028179
15.
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
J Med Chem
; 62(22): 10062-10097, 2019 11 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31487175
16.
Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
PLoS One
; 13(4): e0195486, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29624602
17.
A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aß42 cutoff with concordance to amyloid positron emission tomography imaging.
Alzheimers Dement (Amst)
; 6: 201-209, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28349119
18.
Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease.
Neurobiol Aging
; 27(3): 377-86, 2006 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15927307
19.
Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.
J Neurosci
; 22(9): 3376-85, 2002 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-11978814
20.
Soluble BACE-1 Activity and sAßPPß Concentrations in Alzheimer's Disease and Age-Matched Healthy Control Cerebrospinal Fluid from the Alzheimer's Disease Neuroimaging Initiative-1 Baseline Cohort.
J Alzheimers Dis
; 46(2): 431-40, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25790831