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1.
Mice deficient in NRROS show abnormal microglial development and neurological disorders.
Nat Immunol
; 18(6): 633-641, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28459434
2.
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Cell
; 145(6): 863-74, 2011 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21640374
3.
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord
; 38(3): 386-398, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36807624
4.
Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients.
Int J Mol Sci
; 21(15)2020 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32707880
5.
Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior.
Proc Natl Acad Sci U S A
; 112(4): E371-9, 2015 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25583485
6.
Interfering with the Chronic Immune Response Rescues Chronic Degeneration After Traumatic Brain Injury.
J Neurosci
; 36(38): 9962-75, 2016 09 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-27656033
7.
Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control.
J Neurosci
; 35(5): 2118-32, 2015 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-25653368
8.
Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.
J Neurosci
; 34(24): 8277-88, 2014 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-24920631
9.
A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.
J Neurosci
; 34(19): 6425-37, 2014 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-24806669
10.
Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia.
bioRxiv
; 2024 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38405775
11.
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
J Med Chem
; 67(7): 5758-5782, 2024 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38511649
12.
Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing.
Drug Metab Dispos
; 41(7): 1319-28, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23584887
13.
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients.
Clin Transl Sci
; 15(8): 2010-2023, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35649245
14.
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
J Exp Med
; 219(3)2022 03 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35226042
15.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J Med Chem
; 65(24): 16290-16312, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36469401
16.
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Sci Transl Med
; 14(648): eabj2658, 2022 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35675433
17.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Mol Neurodegener
; 17(1): 41, 2022 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35690868
18.
Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome.
JCI Insight
; 6(19)2021 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34622797
19.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med
; 13(593)2021 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33980574
20.
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.
J Neurosci
; 29(7): 1977-86, 2009 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-19228952