RT-Cloud: A cloud-based software framework to simplify and standardize real-time fMRI.

Real-time fMRI (RT-fMRI) neurofeedback has been shown to be effective in treating neuropsychiatric disorders and holds tremendous promise for future breakthroughs, both with regard to basic science and clinical applications. However, the prevalence of its use has been hampered by computing hardware requirements, the complexity of setting up and running an experiment, and a lack of standards that would foster collaboration. To address these issues, we have developed RT-Cloud (https://github.com/brainiak/rt-cloud), a flexible, cloud-based, open-source Python software package for the execution of RT-fMRI experiments. RT-Cloud uses standardized data formats and adaptable processing streams to support and expand open science in RT-fMRI research and applications. Cloud computing is a key enabling technology for advancing RT-fMRI because it eliminates the need for on-premise technical expertise and high-performance computing; this allows installation, configuration, and maintenance to be automated and done remotely. Furthermore, the scalability of cloud computing makes it easier to deploy computationally-demanding multivariate analyses in real time. In this paper, we describe how RT-Cloud has been integrated with open standards, including the Brain Imaging Data Structure (BIDS) standard and the OpenNeuro database, how it has been applied thus far, and our plans for further development and deployment of RT-Cloud in the coming years.

Directed forgetting of pictures of everyday objects.

Directed forgetting is a laboratory task in which subjects are explicitly cued to forget certain items and remember others. Volitional control over the contents of memory has been used to study clinical disorders, with successful intentional control of memory being a hallmark of a healthy mind. Yet the degree of volitional forgetting over the content of visual long-term memory is unclear when compared to words. Different kinds of visual stimuli (e.g., abstract symbols, line drawings, scenes) may not equally be susceptible to voluntary control in memory, and intentional forgetting studies have shown both twice as much forgetting of pictures compared to words (think/no-think task) and half as much forgetting of pictures compared to words (directed forgetting task). In the present study, we systematically test volitional control over pictures of everyday objects using item-method directed forgetting procedures. We find that subjects are able to intentionally prioritize memory for pictures cued as to be remembered over pictures cued to be forgotten. Here we show that directed forgetting effects are observed using pictures of everyday objects (albeit to a weaker extent compared to directed forgetting of words), suggesting increased confidence for generalization of directed forgetting literature to real-world applications. However, we caution clinical applications of intentional memory control until the underlying direction causing this effect (upregulation of remember-cued items or downregulation of forget-cued items) is known.

The dominance of spatial information in object identity judgments: A persistent congruency bias even amidst conflicting statistical regularities.

Previous studies have posited that spatial location plays a special role in object recognition. Notably, the "spatial congruency bias (SCB)" is a tendency to report objects as the same identity if they are presented at the same location, compared to different locations. Here we found that even when statistical regularities were manipulated in the opposite direction (objects in the same location were three times more likely to be different identities), subjects still exhibited a robust SCB (more likely to report them as the same identity). We replicated this finding across two preregistered experiments. Only in a third experiment where we explicitly informed subjects of the manipulation did the SCB disappear, though the lack of a significantly reversed bias suggests the ingrained congruency bias was not completely overcome. The inclusion of catch trials where the second object was completely masked further bolsters previous evidence that the congruency bias is perceptual, not simply a guessing strategy. These results reinforce the dominant role of spatial information during object recognition and present the SCB as a strong perceptual phenomenon that is incredibly hard to overcome even in the face of opposing regularities and explicit instruction. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

What do laboratory-forgetting paradigms tell us about use-inspired forgetting?

Directed forgetting is a laboratory task in which subjects are told to remember some information and forget other information. In directed forgetting tasks, participants are able to exert intentional control over which information they retain in memory and which information they forget. Forgetting in this task appears to be mediated by intentional control of memory states in which executive control mechanisms suppress unwanted information. Recognition-induced forgetting is another laboratory task in which subjects forget information. Recognizing a target memory induces the forgetting of related items stored in memory. Rather than occurring due to volitional control, recognition-induced forgetting is an incidental by-product of activating items in memory. Here we asked whether intentional directed forgetting or unintentional recognition-induced forgetting is a more robust forgetting effect. While there was a correlation between forgetting effects when the same subjects did both tasks, the magnitude of recognition-induced forgetting was larger than the magnitude of directed forgetting. These results point to practical differences in forgetting outcomes between two commonly used laboratory-forgetting paradigms.

Visual working memory items drift apart due to active, not passive, maintenance.

How are humans capable of maintaining detailed representations of visual items in memory? When required to make fine discriminations, we sometimes implicitly differentiate memory representations away from each other to reduce interitem confusion. However, this separation of representations can inadvertently lead memories to be recalled as biased away from other memory items, a phenomenon termed repulsion bias. Using a nonretinotopically specific working memory paradigm, we found stronger repulsion bias with longer working memory delays, but only when items were actively maintained. These results suggest that (a) repulsion bias can reflect a mnemonic phenomenon, distinct from perceptually driven observations of repulsion bias; and (b) mnemonic repulsion bias is ongoing during maintenance and dependent on attention to internally maintained memory items. These results support theories of working memory where items are represented interdependently and further reveals contexts where stronger attention to working memory items during maintenance increases repulsion bias between them. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Statistical learning as a reference point for memory distortions: Swap and shift errors.

Humans use regularities in the environment to facilitate learning, often without awareness or intent. How might such regularities distort long-term memory? Here, participants studied and reported the colors of objects in a long-term memory paradigm, uninformed that certain colors were sampled more frequently overall. When participants misreported an object's color, these errors were often centered around the average studied color (i.e., "Rich" color), demonstrating swap errors in long-term memory due to imposed statistical regularities. We observed such swap errors regardless of memory load, explicit knowledge, or the distance in color space between the correct color of the tested object and the Rich color. An explicit guessing strategy where participants intentionally made swap errors when uncertain could not fully account for our results. We discuss other potential sources of observed swap errors such as false memory and implicit biased guessing. Although less robust than swap errors, evidence was also observed for subtle shift errors towards or away from the Rich color dependent on the color distance between the correct color and the Rich color. Together, these findings of swap and shift errors provide converging evidence for memory distortion mechanisms induced by a reference point, bridging a gap in the literature between how attention to regularities similarly influences visual working memory and visual long-term memory.

Recognition-induced forgetting of schematically related pictures.

Recognition-induced forgetting is the category-specific forgetting of pictures that occurs when a subset of a category of pictures is recognized, leading to forgetting of the remaining pictures. We have previously shown that recognition-induced forgetting does not operate over categories created by temporal relationships, suggesting that this effect does not operate over episodic memory representations. Here we systematically tested whether schematically related categories of pictures are immune to recognition-induced forgetting. We found that sufficiently weak schematically related memories are vulnerable to recognition-induced forgetting. These results offer an alternative interpretation for evidence that recognition-induced forgetting does not operate over episodic memory representations. Evidence that the strength of schematic grouping modulates forgetting supports a model of recognition-induced forgetting in which the key determinant of forgetting is moderate activation. This is the first demonstration that recognition-induced forgetting operates over perceptually distinct objects, demonstrating the ubiquity of such forgetting.

Attention scales according to inferred real-world object size.

Natural scenes consist of objects of varying shapes and sizes. The impact of object size on visual perception has been well-demonstrated, from classic mental imagery experiments1, to recent studies of object representations reporting topographic organization of object size in the occipito-temporal cortex2. While the role of real-world physical size in perception is clear, the effect of inferred size on attentional selection is ill-defined. Here, we investigate whether inferred real-world object size influences attentional allocation. Across five experiments, attentional allocation was measured in objects of equal retinal size, but varied in inferred real-world size (for example, domino, bulldozer). Following each experiment, participants rated the real-world size of each object. We hypothesized that, if inferred real-world size influences attention, selection in retinal size-matched objects should be less efficient in larger objects. This effect should increase with greater attentional demand. Predictions were supported by faster identified targets in objects inferred to be small than large, with costlier attentional shifting in large than small objects when attentional demand was high. Critically, there was a direct correlation between the rated size of individual objects and response times (and shifting costs). Finally, systematic degradation of size inference proportionally reduced object size effect. It is concluded that, along with retinal size, inferred real-world object size parametrically modulates attention. These findings have important implications for models of attentional control and invite sensitivity to object size for future studies that use real-world images in psychological research.