Deep image prior cine MR fingerprinting with B1 + spin history correction.

PURPOSE: To develop a deep image prior (DIP) reconstruction for B1 + -corrected 2D cine MR fingerprinting (MRF). METHODS: The proposed method combines low-rank (LR) modeling with a DIP to generate cardiac phase-resolved parameter maps without motion correction, employing self-supervised training to enforce consistency with undersampled spiral k-space data. Two implementations were tested: one approach (DIP) for cine T1 , T2 , and M0 mapping, and a second approach (DIP with effective B1 + estimation [DIP-B1]) that also generated an effective B1 + map to correct for errors due to RF transmit inhomogeneities, through-plane motion, and blood flow. Cine MRF data were acquired in 14 healthy subjects and four reconstructions were compared: LR, low-rank motion-corrected (LRMC), DIP, and DIP-B1. Results were compared to diastolic ECG-triggered MRF, MOLLI, and T2 -prep bSSFP. Additionally, bright-blood and dark-blood images calculated from cine MRF maps were used to quantify ventricular function and compared to reference cine measurements. RESULTS: DIP and DIP-B1 outperformed other cine MRF reconstructions with improved noise suppression and delineation of high-resolution details. Within-segment variability in the myocardium (reported as the coefficient of variation for T1 /T2 ) was lowest for DIP-B1 (2.3/8.3%) followed by DIP (2.7/8.7%), LRMC (3.5/10.5%), and LR (15.3/39.6%). Spatial homogeneity improved with DIP-B1 having the lowest intersegment variability (2.6/4.1%). The mean bias in ejection fraction was -1.1% compared to reference cine scans. CONCLUSION: A DIP reconstruction for 2D cine MRF enabled cardiac phase-resolved mapping of T1 , T2 , M0 , and the effective B1 + with improved noise suppression and precision compared to LR and LRMC.

T1 and T2 measurements across multiple 0.55T MRI systems using open-source vendor-neutral sequences.

PURPOSE: To compare T1 and T2 measurements across commercial and prototype 0.55T MRI systems in both phantom and healthy participants using the same vendor-neutral pulse sequences, reconstruction, and analysis methods. METHODS: Standard spin echo measurements and abbreviated protocol measurements of T1, B1, and T2 were made on two prototype 0.55 T systems and two commercial 0.55T systems using an ISMRM/NIST system phantom. Additionally, five healthy participants were imaged at each system using the abbreviated protocol for T1, B1, and T2 measurement. The phantom measurements were compared to NMR-based reference measurements to determine accuracy, and both phantom and in vivo measurements were compared to assess reproducibility and differences between the prototype and commercial systems. RESULTS: Vendor-neutral sequences were implemented across all four systems, and the code for pulse sequences and reconstruction is freely available. For participants, there was no difference in the mean T1 and T2 relaxation times between the prototype and commercial systems. In the phantom, there were no significant differences between the prototype and commercial systems for T1 and T2 measurements using the abbreviated protocol. CONCLUSION: Quantitative T1 and T2 measurements at 0.55T in phantom and healthy participants are not statistically different across the prototype and commercial systems.

Synthetic multi-contrast late gadolinium enhancement imaging using post-contrast magnetic resonance fingerprinting.

Late gadolinium enhancement (LGE) MRI is the non-invasive reference standard for identifying myocardial scar and fibrosis but has limitations, including difficulty delineating subendocardial scar and operator dependence on image quality. The purpose of this work is to assess the feasibility of generating multi-contrast synthetic LGE images from post-contrast T1 and T2 maps acquired using magnetic resonance fingerprinting (MRF). Fifteen consecutive patients with a history of prior ischemic cardiomyopathy (12 men; mean age 63  ±  13 years) were prospectively scanned at 1.5 T between Oct 2020 and May 2021 using conventional LGE and MRF after injection of gadolinium contrast. Three classes of synthetic LGE images were derived from MRF post-contrast T1 and T2 maps: bright-blood phase-sensitive inversion recovery (PSIR), black- and gray-blood T2 -prepared PSIR (T2 -PSIR), and a novel "tissue-optimized" image to enhance differentiation among scar, viable myocardium, and blood. Image quality was assessed on a 1-5 Likert scale by two cardiologists, and contrast was quantified as the mean absolute difference (MAD) in pixel intensities between two tissues, with different methods compared using Kruskal-Wallis with Bonferroni post hoc tests. Per-patient and per-segment scar detection rates were evaluated using conventional LGE images as reference. Image quality scores were highest for synthetic PSIR (4.0) and reference images (3.8), followed by synthetic tissue-optimized (3.3), gray-blood T2 -PSIR (3.0), and black-blood T2 -PSIR (2.6). Among synthetic images, PSIR yielded the highest myocardium/scar contrast (MAD = 0.42) but the lowest blood/scar contrast (MAD = 0.05), and vice versa for T2 -PSIR, while tissue-optimized images achieved a balance among all tissues (myocardium/scar MAD = 0.16, blood/scar MAD = 0.26, myocardium/blood MAD = 0.10). Based on reference mid-ventricular LGE scans, 13/15 patients had myocardial scar. The per-patient sensitivity/accuracy for synthetic images were the following: PSIR, 85/87%; black-blood T2 -PSIR, 62/53%; gray-blood T2 -PSIR, 100/93%; tissue optimized, 100/93%. Synthetic multi-contrast LGE images can be generated from post-contrast MRF data without additional scan time, with initial feasibility shown in ischemic cardiomyopathy patients.

Cardiac MR Fingerprinting: Overview, Technical Developments, and Applications.

Cardiovascular magnetic resonance (CMR) is an established imaging modality with proven utility in assessing cardiovascular diseases. The ability of CMR to characterize myocardial tissue using T1- and T2-weighted imaging, parametric mapping, and late gadolinium enhancement has allowed for the non-invasive identification of specific pathologies not previously possible with modalities like echocardiography. However, CMR examinations are lengthy and technically complex, requiring multiple pulse sequences and different anatomical planes to comprehensively assess myocardial structure, function, and tissue composition. To increase the overall impact of this modality, there is a need to simplify and shorten CMR exams to improve access and efficiency, while also providing reproducible quantitative measurements. Multiparametric MRI techniques that measure multiple tissue properties offer one potential solution to this problem. This review provides an in-depth look at one such multiparametric approach, cardiac magnetic resonance fingerprinting (MRF). The article is structured as follows. First, a brief review of single-parametric and (non-Fingerprinting) multiparametric CMR mapping techniques is presented. Second, a general overview of cardiac MRF is provided covering pulse sequence implementation, dictionary generation, fast k-space sampling methods, and pattern recognition. Third, recent technical advances in cardiac MRF are covered spanning a variety of topics, including simultaneous multislice and 3D sampling, motion correction algorithms, cine MRF, synthetic multicontrast imaging, extensions to measure additional clinically important tissue properties (proton density fat fraction, T2*, and T1ρ), and deep learning methods for image reconstruction and parameter estimation. The last section will discuss potential clinical applications, concluding with a perspective on how multiparametric techniques like MRF may enable streamlined CMR protocols. LEVEL OF EVIDENCE: 5 TECHNICAL EFFICACY: Stage 1.

The future of CMR: All-in-one vs. real-time CMR (Part 2).

Cardiac Magnetic Resonance (CMR) protocols can be lengthy and complex, which has driven the research community to develop new technologies to make these protocols more efficient and patient-friendly. Two different approaches to improving CMR have been proposed, specifically "all-in-one" CMR, where several contrasts and/or motion states are acquired simultaneously, and "real-time" CMR, in which the examination is accelerated to avoid the need for breathholding and/or cardiac gating. The goal of this two-part manuscript is to describe these two different types of emerging rapid CMR protocols. To this end, the vision of all-in-one and real-time imaging are described, along with techniques which have been devised and tested along the pathway of clinical implementation. The pros and cons of the different methods are presented, and the remaining open needs of each are detailed. Part 1 tackles the "All-in-One" approaches, and Part 2 focuses on the "Real-Time" approaches along with an overall summary of these emerging methods.

The future of cardiovascular magnetic resonance: All-in-one vs. real-time (Part 1).

Cardiovascular magnetic resonance (CMR) protocols can be lengthy and complex, which has driven the research community to develop new technologies to make these protocols more efficient and patient-friendly. Two different approaches to improving CMR have been proposed, specifically "all-in-one" CMR, where several contrasts and/or motion states are acquired simultaneously, and "real-time" CMR, in which the examination is accelerated to avoid the need for breathholding and/or cardiac gating. The goal of this two-part manuscript is to describe these two different types of emerging rapid CMR. To this end, the vision of each is described, along with techniques which have been devised and tested along the pathway of clinical implementation. The pros and cons of the different methods are presented, and the remaining open needs of each are detailed. Part 1 will tackle the "all-in-one" approaches, and Part 2 the "real-time" approaches along with an overall summary of these emerging methods.

Three-dimensional sector-wise golden angle-improved k-space uniformity after electrocardiogram binning.

PURPOSE: To develop and evaluate a 3D sector-wise golden-angle (3D-SWIG) profile ordering scheme for cardiovascular MR cine imaging that maintains high k-space uniformity after electrocardiogram (ECG) binning. METHOD: Cardiovascular MR (CMR) was performed at 1.5 T. A balanced SSFP pulse sequence was implemented with a novel 3D-SWIG radial ordering, where k-space was divided into wedges, and each wedge was acquired in a separate heartbeat. The high uniformity of k-space coverage after physiological binning can be used to perform functional imaging using a very short acquisition. The 3D-SWIG was compared with two commonly used 3D radial trajectories for CMR (i.e., double golden angle and spiral phyllotaxis) in numerical simulations. Free-breathing 3D-SWIG and conventional breath-held 2D cine were compared in patients (n = 17) referred clinically for CMR. Quantitative comparison was performed based on left ventricular segmentation. RESULTS: Numerical simulations showed that 3D-SWIG both required smaller steps between successive readouts and achieved better k-space sampling uniformity after binning than either the double golden angle or spiral phyllotaxis trajectories. In vivo evaluation showed that measurements of left ventricular ejection fraction calculated from a 48 heart-beat free-breathing 3D-SWIG acquisition were highly reproducible and agreed with breath-held 2D-Cartesian cine (mean ± SD difference of -3.1 ± 3.5% points). CONCLUSIONS: The 3D-SWIG acquisition offers a simple solution for highly improved k-space uniformity after physiological binning. The feasibility of the 3D-SWIG method is demonstrated in this study through whole-heart cine imaging during free breathing with an acquisition time of less than 1 min.

Self-calibrated through-time spiral GRAPPA for real-time, free-breathing evaluation of left ventricular function.

PURPOSE: Through-time spiral GRAPPA is a real-time imaging technique that enables ungated, free-breathing evaluation of the left ventricle. However, it requires a separate fully-sampled calibration scan to calculate GRAPPA weights. A self-calibrated through-time spiral GRAPPA method is proposed that uses a specially designed spiral trajectory with interleaved arm ordering such that consecutive undersampled frames can be merged to form calibration data, eliminating the separate fully-sampled acquisition. THEORY AND METHODS: The proposed method considers the time needed to acquire data at all points in a GRAPPA calibration kernel when using interleaved arm ordering. Using this metric, simulations were performed to design a spiral trajectory for self-calibrated GRAPPA. Data were acquired in healthy volunteers using the proposed method and a comparison electrocardiogram-gated and breath-held cine scan. Left ventricular functional values and image quality are compared. RESULTS: A 12-arm spiral trajectory was designed with a temporal resolution of 32.72 ms/cardiac phase with an acceleration factor of 3. Functional values calculated using the proposed method and the gold-standard method were not statistically significantly different (paired t-test, p < 0.05). Image quality ratings were lower for the proposed method, with statistically significantly different ratings (Wilcoxon signed rank test, p < 0.05) for two of five image quality aspects rated (level of artifact, blood-myocardium contrast). CONCLUSIONS: A self-calibrated through-time spiral GRAPPA reconstruction can enable ungated, free-breathing evaluation of the left ventricle in 71 s. Functional values are equivalent to a gold-standard cine technique, although some aspects of image quality may be inferior due to the real-time nature of the data collection.

Quality assessment of routine brain imaging at 0.55 T: initial experience in a clinical workflow.

The purpose of this study was to assess the quality of clinical brain imaging in healthy subjects and patients on an FDA-approved commercial 0.55 T MRI scanner, and to provide information about the feasibility of using this scanner in a clinical workflow. In this IRB-approved study, brain examinations on the scanner were prospectively performed in 10 healthy subjects (February-April 2022) and retrospectively derived from 44 patients (February-July 2022). Images collected using the following pulse sequences were available for assessment: axial DWI (diffusion-weighted imaging), apparent diffusion coefficient maps, 2D axial fluid-attenuated inversion recovery images, axial susceptibility-weighted images (both magnitude and phase), sagittal T1 -weighted (T1w) Sampling Perfection with Application Optimized Contrast images, sagittal T1w MPRAGE (magnetization prepared rapid gradient echo) with contrast enhancement, axial T1w turbo spin echo (TSE) with and without contrast enhancement, and axial T2 -weighted TSE. Two readers retrospectively and independently evaluated image quality and specific anatomical features in a blinded fashion on a four-point Likert scale, with a score of 1 being unacceptable and 4 being excellent, and determined the ability to answer the clinical question in patients. For each category of image sequences, the mean, standard deviation, and percentage of unacceptable quality images (<2) were calculated. Acceptable (rating ≥ 2) image quality was achieved at 0.55 T in all sequences for patients and 85% of the sequences for healthy subjects. Radiologists were able to answer the clinical question in all patients scanned. In total, 50% of the sequences used in patients and about 60% of the sequences used in healthy subjects exhibited good (rating ≥ 3) image quality. Based on these findings, we conclude that diagnostic quality clinical brain images can be successfully collected on this commercial 0.55 T scanner, indicating that the routine brain imaging protocol may be deployed on this system in the clinical workflow.

Assessment of MRF for simultaneous T1 and T2 quantification and water-fat separation in the liver at 0.55 T.

OBJECTIVE: The goal of this work was to assess the feasibility of performing MRF in the liver on a 0.55 T scanner and to examine the feasibility of water-fat separation using rosette MRF at 0.55 T. MATERIALS AND METHODS: Spiral and rosette MRF sequences were implemented on a commercial 0.55 T scanner. The accuracy of both sequences in T1 and T2 quantification was validated in the ISMRM/NIST system phantom. The efficacy of rosette MRF in water-fat separation was evaluated in simulations and water/oil phantoms. Both spiral and rosette MRF were performed in the liver of healthy subjects. RESULTS: In the ISMRM/NIST phantom, both spiral and rosette MRF achieved good agreement with reference values in T1 and T2 measurements. In addition, rosette MRF enables water-fat separation and can generate water- and fat- specific T1 maps, T2 maps, and proton density images from the same dataset for a spatial resolution of 1.56 × 1.56 × 5mm3 within the acquisition time of 15 s. CONCLUSION: It is feasible to measure T1 and T2 simultaneously in the liver using MRF on a 0.55 T system with lower performance gradients compared to state-of-the-art 1.5 T and 3 T systems within an acquisition time of 15 s. In addition, rosette MRF enables water-fat separation along with T1 and T2 quantification with no time penalty.

A low-rank deep image prior reconstruction for free-breathing ungated spiral functional CMR at 0.55 T and 1.5 T.

OBJECTIVE: This study combines a deep image prior with low-rank subspace modeling to enable real-time (free-breathing and ungated) functional cardiac imaging on a commercial 0.55 T scanner. MATERIALS AND METHODS: The proposed low-rank deep image prior (LR-DIP) uses two u-nets to generate spatial and temporal basis functions that are combined to yield dynamic images, with no need for additional training data. Simulations and scans in 13 healthy subjects were performed at 0.55 T and 1.5 T using a golden angle spiral bSSFP sequence with images reconstructed using [Formula: see text]-ESPIRiT, low-rank plus sparse (L + S) matrix completion, and LR-DIP. Cartesian breath-held ECG-gated cine images were acquired for reference at 1.5 T. Two cardiothoracic radiologists rated images on a 1-5 scale for various categories, and LV function measurements were compared. RESULTS: LR-DIP yielded the lowest errors in simulations, especially at high acceleration factors (R [Formula: see text] 8). LR-DIP ejection fraction measurements agreed with 1.5 T reference values (mean bias - 0.3% at 0.55 T and - 0.2% at 1.5 T). Compared to reference images, LR-DIP images received similar ratings at 1.5 T (all categories above 3.9) and slightly lower at 0.55 T (above 3.4). CONCLUSION: Feasibility of real-time functional cardiac imaging using a low-rank deep image prior reconstruction was demonstrated in healthy subjects on a commercial 0.55 T scanner.

Cardiac Magnetic Resonance Fingerprinting: Potential Clinical Applications.

PURPOSE OF REVIEW: Cardiac magnetic resonance fingerprinting (cMRF) has developed as a technique for rapid, multi-parametric tissue property mapping that has potential to both improve cardiac MRI exam efficiency and expand the information captured. In this review, we describe the cMRF technique, summarize technical developments and in vivo reports, and highlight potential clinical applications. RECENT FINDINGS: Technical developments in cMRF continue to progress rapidly, including motion compensated reconstruction, additional tissue property quantification, signal time course analysis, and synthetic LGE image generation. Such technical developments can enable simplified CMR protocols by combining multiple evaluations into a single protocol and reducing the number of breath-held scans. cMRF continues to be reported for use in a range of pathologies; however barriers to clinical implementation remain. Technical developments are described in this review, followed by a focus on potential clinical applications that they may support. Clinical translation of cMRF could shorten protocols, improve CMR accessibility, and provide additional information as compared to conventional cardiac parametric mapping methods. Current needs for clinical implementation are discussed, as well as how those needs may be met in order to bring cMRF from its current research setting to become a viable tool for patient care.

Optimization of through-time radial GRAPPA with coil compression and weight sharing.

PURPOSE: This work proposes principal component analysis (PCA) coil compression and weight sharing to reduce acquisition and reconstruction time of through-time radial GRAPPA. METHODS: Through-time radial GRAPPA enables ungated free-breathing motion-resolved cardiac imaging but requires a long calibration acquisition and GRAPPA weight calculation time. PCA coil compression reduces calibration data requirements and associated acquisition time, and weight sharing reduces the number of unique GRAPPA weight sets and associated weight computation time. In vivo cardiac data reconstructed with coil compression and weight sharing are compared to a gold standard to demonstrate improvement in calibration acquisition and reconstruction performance with minimal loss of image quality. RESULTS: Coil compression from 30 physical to 12 virtual coils (90% of signal variance) decreases requisite calibration data by 60%, reducing calibration acquisition time to 6.7 s/slice from 31.5 s/slice reported in original through-time radial GRAPPA work. Resulting images have small increase in RMS error (RMSE). Reconstruction with a weight sharing factor of 8 results in eight-fold reduction in GRAPPA weight calculation time with a comparable RMSE to reconstructions with no weight sharing. Optimized parameters for coil compression and weight sharing applied to reconstructions enables images to be collected with a temporal resolution of 66 ms/frame and spatial resolution of 2.34 × 2.34 mm while reducing calibration acquisition time from 34 to 6.7 s, weight calculation time from 200 to 3 s, and weight application time 18 to 5 s. CONCLUSION: Coil compression and weight sharing applied to through-time radial GRAPPA enables fast free-breathing ungated cardiac cine without compromising image quality.

Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue.

PURPOSE: To evaluate multicenter repeatability and reproducibility of T1 and T2 maps generated using MR fingerprinting (MRF) in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI system phantom and in prostatic tissues. METHODS: MRF experiments were performed on 5 different 3 Tesla MRI scanners at 3 different institutions: University Hospitals Cleveland Medical Center (Cleveland, OH), Brigham and Women's Hospital (Boston, MA) in the United States, and Diagnosticos da America (Rio de Janeiro, RJ) in Brazil. Raw MRF data were reconstructed using a Gadgetron-based MRF online reconstruction pipeline to yield quantitative T1 and T2 maps. The repeatability of T1 and T2 values over 6 measurements in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI system phantom was assessed to demonstrate intrascanner variation. The reproducibility between the 4 clinical scanners was assessed to demonstrate interscanner variation. The same-day test-retest normal prostate mean T1 and T2 values from peripheral zone and transitional zone were also compared using the intraclass correlation coefficient and Bland-Altman analysis. RESULTS: The intrascanner variation of values measured using MRF was less than 2% for T1 and 4.7% for T2 for relaxation values, within the range of 307.7 to 2360 ms for T1 and 19.1 to 248.5 ms for T2 . Interscanner measurements showed that the T1 variation was less than 4.9%, and T2 variation was less than 8.1% between multicenter scanners. Both T1 and T2 values in in vivo prostatic tissue demonstrated high test-retest reliability (intraclass correlation coefficient > 0.92) and strong linear correlation (R2  > 0.840). CONCLUSION: Prostate MRF measurements of T1 and T2 are repeatable and reproducible between MRI scanners at different centers on different continents for the above measurement ranges.

30-minute CMR for common clinical indications: a Society for Cardiovascular Magnetic Resonance white paper.

BACKGROUND: Despite decades of accruing evidence supporting the clinical utility of cardiovascular magnetic resonance (CMR), adoption of CMR in routine cardiovascular practice remains limited in many regions of the world. Persistent use of long scan times of 60 min or more contributes to limited adoption, though techniques available on most scanners afford routine CMR examination within 30 min. Incorporating such techniques into standardize protocols can answer common clinical questions in daily practice, including those related to heart failure, cardiomyopathy, ventricular arrhythmia, ischemic heart disease, and non-ischemic myocardial injury. BODY: In this white paper, we describe CMR protocols of 30 min or shorter duration with routine techniques with or without stress perfusion, plus specific approaches in patient and scanner room preparation for efficiency. Minimum requirements for the scanner gradient system, coil hardware and pulse sequences are detailed. Recent advances such as quantitative myocardial mapping and other add-on acquisitions can be incorporated into the proposed protocols without significant extension of scan duration for most patients. CONCLUSION: Common questions in clinical cardiovascular practice can be answered in routine CMR protocols under 30 min; their incorporation warrants consideration to facilitate increased access to CMR worldwide.

MR fingerprinting of the prostate.

Multiparametric magnetic resonance imaging (mpMRI) has been adopted as the key tool for detection, localization, characterization, and risk stratification of patients suspected to have prostate cancer. Despite advantages over systematic biopsy, the interpretation of prostate mpMRI has limitations including a steep learning curve, leading to considerable interobserver variation. There is growing interest in clinical translation of quantitative imaging techniques for more objective lesion assessment. However, traditional mapping techniques are slow, precluding their use in the clinic. Magnetic resonance fingerprinting (MRF) is an efficient approach for quantitative maps of multiple tissue properties simultaneously. The T1 and T2 values obtained with MRF have been validated with phantom studies as well as in normal volunteers and patients. Studies have shown that MRF-derived T1 and T2 along with ADC values are all significant independent predictors in the differentiation between normal prostate tissue and prostate cancer, and hold promise in differentiating low and intermediate/high-grade cancers. This review seeks to introduce the basics of the prostate MRF technique, discuss the potential applications of prostate MRF for the characterization of prostate cancer, and describes ongoing areas of research.

Deep learning reconstruction for cardiac magnetic resonance fingerprinting T1 and T2 mapping.

PURPOSE: To develop a deep learning method for rapidly reconstructing T1 and T2 maps from undersampled electrocardiogram (ECG) triggered cardiac magnetic resonance fingerprinting (cMRF) images. METHODS: A neural network was developed that outputs T1 and T2 values when given a measured cMRF signal time course and cardiac RR interval times recorded by an ECG. Over 8 million cMRF signals, corresponding to 4000 random cardiac rhythms, were simulated for training. The training signals were corrupted by simulated k-space undersampling artifacts and random phase shifts to promote robust learning. The deep learning reconstruction was evaluated in Monte Carlo simulations for a variety of cardiac rhythms and compared with dictionary-based pattern matching in 58 healthy subjects at 1.5T. RESULTS: In simulations, the normalized root-mean-square error (nRMSE) for T1 was below 1% in myocardium, blood, and liver for all tested heart rates. For T2 , the nRMSE was below 4% for myocardium and liver and below 6% for blood for all heart rates. The difference in the mean myocardial T1 or T2 observed in vivo between dictionary matching and deep learning was 3.6 ms for T1 and -0.2 ms for T2 . Whereas dictionary generation and pattern matching required more than 4 min per slice, the deep learning reconstruction only required 336 ms. CONCLUSION: A neural network is introduced for reconstructing cMRF T1 and T2 maps directly from undersampled spiral images in under 400 ms and is robust to arbitrary cardiac rhythms, which paves the way for rapid online display of cMRF maps.

Myocardial T1 and T2 quantification and water-fat separation using cardiac MR fingerprinting with rosette trajectories at 3T and 1.5T.

PURPOSE: This work aims to develop an approach for simultaneous water-fat separation and myocardial T1 and T2 quantification based on the cardiac MR fingerprinting (cMRF) framework with rosette trajectories at 3T and 1.5T. METHODS: Two 15-heartbeat cMRF sequences with different rosette trajectories designed for water-fat separation at 3T and 1.5T were implemented. Water T1 and T2 maps, water image, and fat image were generated with B0 inhomogeneity correction using a B0 map derived from the cMRF data themselves. The proposed water-fat separation rosette cMRF approach was validated in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI system phantom and water/oil phantoms. It was also applied for myocardial tissue mapping of healthy subjects at both 3T and 1.5T. RESULTS: Water T1 and T2 values measured using rosette cMRF in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology phantom agreed well with the reference values. In the water/oil phantom, oil was well suppressed in the water images and vice versa. Rosette cMRF yielded comparable T1 but 2~3 ms higher T2 values in the myocardium of healthy subjects than the original spiral cMRF method. Epicardial fat deposition was also clearly shown in the fat images. CONCLUSION: Rosette cMRF provides fat images along with myocardial T1 and T2 maps with significant fat suppression. This technique may improve visualization of the anatomical structure of the heart by separating water and fat and could provide value in diagnosing cardiac diseases associated with fibrofatty infiltration or epicardial fat accumulation. It also paves the way toward comprehensive myocardial tissue characterization in a single scan.

Prospective Evaluation of Repeatability and Robustness of Radiomic Descriptors in Healthy Brain Tissue Regions In Vivo Across Systematic Variations in T2-Weighted Magnetic Resonance Imaging Acquisition Parameters.

BACKGROUND: Radiomic descriptors from magnetic resonance imaging (MRI) are promising for disease diagnosis and characterization but may be sensitive to differences in imaging parameters. OBJECTIVE: To evaluate the repeatability and robustness of radiomic descriptors within healthy brain tissue regions on prospectively acquired MRI scans; in a test-retest setting, under controlled systematic variations of MRI acquisition parameters, and after postprocessing. STUDY TYPE: Prospective. SUBJECTS: Fifteen healthy participants. FIELD STRENGTH/SEQUENCE: A 3.0 T, axial T2 -weighted 2D turbo spin-echo pulse sequence, 181 scans acquired (2 test/retest reference scans and 12 with systematic variations in contrast weighting, resolution, and acceleration per participant; removing scans with artifacts). ASSESSMENT: One hundred and forty-six radiomic descriptors were extracted from a contiguous 2D region of white matter in each scan, before and after postprocessing. STATISTICAL TESTS: Repeatability was assessed in a test/retest setting and between manual and automated annotations for the reference scan. Robustness was evaluated between the reference scan and each group of variant scans (contrast weighting, resolution, and acceleration). Both repeatability and robustness were quantified as the proportion of radiomic descriptors that fell into distinct ranges of the concordance correlation coefficient (CCC): excellent (CCC > 0.85), good (0.7 ≤ CCC ≤ 0.85), moderate (0.5 ≤ CCC < 0.7), and poor (CCC < 0.5); for unprocessed and postprocessed scans separately. RESULTS: Good to excellent repeatability was observed for 52% of radiomic descriptors between test/retest scans and 48% of descriptors between automated vs. manual annotations, respectively. Contrast weighting (TR/TE) changes were associated with the largest proportion of highly robust radiomic descriptors (21%, after processing). Image resolution changes resulted in the largest proportion of poorly robust radiomic descriptors (97%, before postprocessing). Postprocessing of images with only resolution/acceleration differences resulted in 73% of radiomic descriptors showing poor robustness. DATA CONCLUSIONS: Many radiomic descriptors appear to be nonrobust across variations in MR contrast weighting, resolution, and acceleration, as well in test-retest settings, depending on feature formulation and postprocessing. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.

Cardiac cine magnetic resonance fingerprinting for combined ejection fraction, T1 and T2 quantification.

This study introduces a technique called cine magnetic resonance fingerprinting (cine-MRF) for simultaneous T1 , T2 and ejection fraction (EF) quantification. Data acquired with a free-running MRF sequence are retrospectively sorted into different cardiac phases using an external electrocardiogram (ECG) signal. A low-rank reconstruction with a finite difference sparsity constraint along the cardiac motion dimension yields images resolved by cardiac phase. To improve SNR and precision in the parameter maps, these images are nonrigidly registered to the same phase and matched to a dictionary to generate T1 and T2 maps. Cine images for computing left ventricular volumes and EF are also derived from the same data. Cine-MRF was tested in simulations using a numerical relaxation phantom. Phantom and in vivo scans of 19 subjects were performed at 3 T during a 10.9 seconds breath-hold with an in-plane resolution of 1.6 x 1.6 mm2 and 24 cardiac phases. Left ventricular EF values obtained with cine-MRF agreed with the conventional cine images (mean bias -1.0%). Average myocardial T1 times in diastole/systole were 1398/1391 ms with cine-MRF, 1394/1378 ms with ECG-triggered cardiac MRF (cMRF) and 1234/1212 ms with MOLLI; and T2 values were 30.7/30.3 ms with cine-MRF, 32.6/32.9 ms with ECG-triggered cMRF and 37.6/41.0 ms with T2 -prepared FLASH. Cine-MRF and ECG-triggered cMRF relaxation times were in good agreement. Cine-MRF T1 values were significantly longer than MOLLI, and cine-MRF T2 values were significantly shorter than T2 -prepared FLASH. In summary, cine-MRF can potentially streamline cardiac MRI exams by combining left ventricle functional assessment and T1 -T2 mapping into one time-efficient acquisition.