Asunto(s)
Proteínas de Fusión bcr-abl/análisis , Hematopoyesis Extramedular , Células Madre Hematopoyéticas/patología , Leucemia Mieloide de Fase Crónica/diagnóstico , Células Madre Neoplásicas/patología , Derrame Pericárdico/patología , Líquido Pericárdico/fisiología , Pericarditis/patología , Anciano , Biomarcadores de Tumor , Linaje de la Célula , Femenino , Células Madre Hematopoyéticas/química , Humanos , Leucemia Mieloide de Fase Crónica/complicaciones , Leucemia Mieloide de Fase Crónica/patología , Leucocitosis/etiología , Células Madre Neoplásicas/química , Derrame Pericárdico/complicaciones , Líquido Pericárdico/química , Líquido Pericárdico/citología , Pericarditis/complicacionesRESUMEN
Thrombocytopenia is one of the most common hematological abnormalities observed during pregnancy, and in rare cases, this may be the first indicator of an underlying hematological malignancy. Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder of which thrombocytopenia is a recurrent presenting feature. A case of pancytopenia presenting in pregnancy is described in which the thrombocytopenia persisted postpartum coincidental with a vesicular, pustular rash characterised as Sweet's syndrome. Hematological, histological, immunophenotypic, and molecular investigations confirmed the presence of HCL. The patient was treated with cladribine resulting in resolution of Sweet's syndrome, hematological remission from HCL, and achievement of a normal platelet count. This case highlights the need to maintain a wide differential diagnosis for presentations of pancytopenia or thrombocytopenia in pregnancy and the requirement for follow-up investigation of unusual cases with a lack of response to steroids or immunoglobulin.