1.
J Org Chem
; 86(3): 2200-2209, 2021 02 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33211487
RESUMEN
A synthetic strategy to fused bicyclic piperidines-building blocks for medicinal chemistry-is developed. The key step was an intramolecular [2 + 2]-photocyclization. The photochemical step was performed on a gram scale. Crystallographic analysis of the obtained compounds revealed that they occupy a novel chemical space and can be considered as elongated analogues of 3-substituted piperidines.