Detalles de la búsqueda
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31969702
2.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29678460
3.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28268136
4.
Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor.
Proc Natl Acad Sci U S A
; 105(6): 1838-43, 2008 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-18252827
5.
Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.
Bioorg Med Chem Lett
; 20(20): 6067-71, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20817523
6.
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorg Med Chem Lett
; 20(8): 2452-5, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20346655
7.
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
J Med Chem
; 63(10): 5585-5623, 2020 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32324999
8.
Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.
BMC Cancer
; 9: 314, 2009 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-19732452
9.
Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorg Med Chem Lett
; 19(6): 1718-21, 2009 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19217287
10.
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Cancer Res
; 77(11): 2976-2989, 2017 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28416490
11.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28368119
12.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-28949521
13.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J Med Chem
; 49(13): 3832-49, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789740
14.
Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models.
Clin Cancer Res
; 11(7): 2680-5, 2005 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15814649
15.
Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2.
Cancer Res
; 63(22): 7861-9, 2003 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-14633714
16.
MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.
Mol Cancer Ther
; 14(8): 1837-47, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26013319
17.
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J Med Chem
; 58(5): 2180-94, 2015 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25679114
18.
Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.
J Med Chem
; 58(9): 4089, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25933255
19.
Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.
J Biol Chem
; 283(35): 23721-30, 2008 Aug 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-18559346
20.
Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.
J Proteome Res
; 7(11): 4807-20, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18828628