1.
J Org Chem
; 88(2): 1245-1255, 2023 Jan 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36628963
RESUMEN
A novel organobase-catalyzed umpolung reaction of amides was disclosed. This method provides an efficient method to generate and transfer carbamoyl anions. In this transformation, some of the inherent disadvantages of carbamoyl metal were avoided. The mechanistic analysis revealed that the reaction proceeds through polarity inversion of amide, and various carbamoyl anions were applied in the reaction. Moreover, a wide range of substrates was achieved with moderate to excellent yield.