Fronto-occipital mismatch responses in pre-attentive detection of visual changes: Implication on a generic brain network underlying Mismatch Negativity (MMN).

Current theories of pre-attentive change detection suggest a regularity or prediction violation mechanism involving a frontotemporal network. Modulations of the early inferior frontal cortex (IFC) mismatch response representing the effort in comparing a stimulus to the prediction, the superior temporal cortex (STC) response indicating deviance detection, and the late IFC response representing prediction model updating were consistently demonstrated in auditory change detection using event-related optical signal (EROS). If the prediction violation hypothesis is universal, a generic neural mechanism should be found in all sensory modalities. We postulated a generic fronto-sensory cortical network underlying the prediction violation mechanism: the IFC is responsible for non-modality-specific prediction processes while the sensory cortices are responsible for modality-specific error signal generation process. This study examined the involvement of the IFC-occipital cortex (OC) network in visual pre-attentive change detection. The EROS mismatch responses to deviant bar arrays violating a fixed orientation regularity (low in regularity abstractness) were compared to that of deviant violating a rotational orientation regularity (high in abstractness) while the information available for establishing the prediction model was manipulated by varying the number of standards preceding the deviants. Modulations of the IFCOC mismatch response patterns by abstractness and train length reflected the processing demands on the prediction processes and were similar to that of the IFC-STC network in auditory change detection. These findings demonstrated that the fronto-sensory cortical network is not unique to auditory pre-attentive change detection and provided supports for a universal neural mechanism across sensory modalities as suggested by the prediction violation hypothesis.

Functional connectivity of the frontotemporal network in preattentive detection of abstract changes: Perturbs and observes with transcranial magnetic stimulation and event-related optical signal.

Current theories of automatic or preattentive change detection suggest a regularity or prediction violation mechanism involving functional connectivity between the inferior frontal cortex (IFC) and the superior temporal cortex (STC). By disrupting the IFC function with transcranial magnetic stimulation (TMS) and recording the later STC mismatch response with event-related optical signal (EROS), previous study demonstrated a causal IFC-to-STC functional connection in detecting a pitch or physical change. However, physical change detection can be achieved by memory comparison of the physical features and may not necessarily involve regularity/rule extraction and prediction. The current study investigated the IFC-STC functional connectivity in detecting rule violation (i.e., an abstract change). Frequent standard tone pairs with a constant relative pitch difference, but varying pitches, were presented to establish a pitch interval rule. This abstract rule was violated by deviants with reduced relative pitch intervals. The EROS STC mismatch response to the deviants was abolished by the TMS applied at the IFC 80 ms after deviance onset, but preserved in the spatial (TMS on vertex), auditory (TMS sound), and temporal (200 ms after deviance onset) control conditions. These results demonstrate the IFC-STC connection in preattentive abstract change detection and support the regularity or prediction violation account.

Full-form vs. combinatorial processing of Chinese compound words: Evidence from mismatch negativity.

This study examined whether Chinese spoken compound words are processed via full-form access or combination through morphemes by recording mismatch negativity (MMN). MMN has been shown to be larger for linguistic units that involves full-form access (lexical MMN enhancement) and smaller for separate but combinable units (combinatorial MMN reduction). Chinse compound words were compared against pseudocompounds, which do not have full-form representations in the long-term memory and are "illegal" combinations. All stimuli were disyllabic (bimorphemic). Word frequency was manipulated with the prediction that low-frequency compounds are more likely processed combinatorially, while high-frequency ones are more likely accessed in full forms. The results showed that low-frequency words elicited smaller MMNs than pseudocompounds, which supported the prediction of combinatorial processing. However, neither MMN enhancement nor reduction was found for high-frequency words. These results were interpreted within the dual-route model framework that assumes simultaneous access to words and morphemes.

The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study.

BACKGROUND: The prediction violation account of automatic or pre-attentive change detection assumed that the inferior frontal cortex (IFC) is involved in establishing a prediction model for detecting unexpected changes. Evidence supporting the IFC's contribution to prediction model is mainly based on the Mismatch Negativity (MMN) to deviants violating predictions that are established based on the frequently presented standard events. However, deviant detection involves processes, such as events comparison, other than prediction model establishment. OBJECTIVE: The current study investigated the critical role of the IFC in establishing a prediction model during standards processing for subsequent deviant detection. METHODS: Transcranial Magnetic Stimulation (TMS) was applied at the IFC to disrupt the processing of the initial 2 or 5 standards of a 3-, 6-, or 9-standard train, while the MMN responses to pitch deviant presented after the standard trains were recorded and compared. RESULTS: An abolishment of MMN was only observed when TMS was delivered to the IFC at the initial 2 standards of the 3-standard train, but not at the initial 5 standards, or when TMS at the vertex or TMS sound recording was applied. The MMNs were also preserved when IFC TMS, vertex TMS, or TMS sound recording was applied at the initial 2 or 5 standards of longer trains. CONCLUSION: The IFC plays a critical role in processing the initial standards of a short standard train for subsequent deviant detection. This result is consistent with the prediction violation account that the IFC is important for establishing the prediction model.