1.
Bioorg Med Chem Lett
; 19(17): 5246-9, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19620004
RESUMEN
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral profiles of selected compounds are also presented.