Distinct fMRI patterns colocalized in the cingulate cortex underlie the after-effects of cognitive control on pain.

Demanding tasks can influence following behaviors but the underlying mechanisms remain largely unclear. In the present functional magnetic resonance imaging (fMRI) study, we used multivariate pattern analyses (MVPA) to compare patterns of brain activity associated with pain in response to noxious stimuli administered after a task requiring cognitive control (Stroop) and evaluate their functional interaction based on a mediation analysis model. We found that performing a difficult cognitive task leads to subsequent increases in pain and pain-related multivariate responses across the brain and within the anterior mid-cingulate cortex (aMCC). Moreover, an aMCC pattern predictive of task performance was further reactivated during pain and predicted ensuing increases in pain-related brain responses. This suggests functional interactions between distinct but partly co-localized neural networks underlying executive control and pain. These findings offer a new perspective on the functional role of the cingulate cortex in pain and cognition and provide a promising framework to investigate dynamical interactions between partly overlapping brain networks.

[Implication of cognitive control capacity in pain experience]. / Implication de la capacité de contrôle cognitif dans l'experience de la douleur.

Chronic pain is often associated with several symptoms in various areas such as depression, irritability, attentional difficulties, or interpersonal distress. Evidence suggests that these comorbidities may be explained by a limited capacity of individuals to exert cognitive control on thoughts, emotions, or behaviors. A decrease of this capacity of control could contribute to the development and maintenance of chronic pain and its associated symptoms. Benefits of the cognitive-behavioral therapy in the treatment of chronic pain may be explained by learning efficient and less costly pain coping strategies in terms of cognitive control capacity.

Do sadness-primes make me work harder because they make me sad?

This experiment sought to clarify the potential role of emotional feelings in the systematic impact of implicitly processed affective stimuli on mental effort mobilisation. Participants worked on an attention task during which they were primed with suboptimally presented happiness versus sadness expressions. Before the task, half the participants received a cue for the possible affective influence of "flickers" to be presented during the task. This manipulation usually reduces the impact of conscious feelings on resource mobilisation. As anticipated, sadness primes resulted in higher experienced task demand and higher mental effort (stronger cardiac contractility assessed as shortened pre-ejection period) than happiness primes. Most importantly, instead of reducing the prime effects on mental effort, the cue manipulation significantly increased participants' effort in general, reflecting additional cognitive demand. The results speak against the idea that affect primes influence effort mobilisation by eliciting conscious emotional feelings.

Distraction and cognitive control independently impact parietal and prefrontal response to pain.

Previous studies have found that distracting someone through a challenging activity leads to hypoalgesia, an effect mediated by parietal and prefrontal processes. Other studies suggest that challenging activities affect the ability to regulate one's aching experiences, due to the partially common neural substrate between cognitive control and pain at the level of the medial prefrontal cortex. We investigated the effects of distraction and cognitive control on pain by delivering noxious stimulations during or after a Stroop paradigm (requiring high cognitive load) or a neutral condition. We found less-intense and unpleasant subjective pain ratings during (compared to after) task execution. This hypoalgesia was associated with enhanced activity at the level of the dorsolateral prefrontal cortex and the posterior parietal cortex, which also showed negative connectivity with the insula. Furthermore, multivariate pattern analysis revealed that distraction altered the neural response to pain, by making it more similar to that associated with previous Stroop tasks. All these effects were independent of the nature of the task, which, instead, led to a localized neural modulation around the anterior cingulate cortex. Overall, our study underscores the role played by two facets of human executive functions, which exert an independent influence on the neural response to pain.

An integrative effort: Bridging motivational intensity theory and recent neurocomputational and neuronal models of effort and control allocation.

An increasing number of cognitive, neurobiological, and computational models have been proposed in the last decade, seeking to explain how humans allocate physical or cognitive effort. Most models share conceptual similarities with motivational intensity theory (MIT), an influential classic psychological theory of motivation. Yet, little effort has been made to integrate such models, which remain confined within the explanatory level for which they were developed, that is, psychological, computational, neurobiological, and neuronal. In this critical review, we derive novel analyses of three recent computational and neuronal models of effort allocation-the expected value of control theory, the reinforcement meta-learner (RML) model, and the neuronal model of attentional effort-and establish a formal relationship between these models and MIT. Our analyses reveal striking similarities between predictions made by these models, with a shared key tenet: a nonmonotonic relationship between perceived task difficulty and effort, following a sawtooth or inverted U shape. In addition, the models converge on the proposition that the dorsal anterior cingulate cortex may be responsible for determining the allocation of effort and cognitive control. We conclude by discussing the distinct contributions and strengths of each theory toward understanding neurocomputational processes of effort allocation. Finally, we highlight the necessity for a unified understanding of effort allocation, by drawing novel connections between different theorizing of adaptive effort allocation as described by the presented models. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Pain and gain: Monetary incentive moderates pain's impact on effort-related cardiac response.

Ample evidence suggests that pain leads to additional demand in cognitive functioning, presumably due to its negative affective component and its propensity to capture attention. To highlight the role of motivational incentive, two experiments tested the combined effect of pain and monetary incentive on effort-related cardiovascular response during cognitive performance. In both studies, healthy volunteers received individually adjusted painful or nonpainful thermal stimulations during a difficult cognitive task (4-back task in Experiment 1; short-term memory task in Experiment 2) and expected high (12 Swiss Francs in both experiments) or low monetary incentive (1 Swiss Franc in Experiment 1; 0.10 Swiss Francs in Experiment 2) for successful performance. Effort was primarily assessed as changes in cardiac pre-ejection period (PEP). We predicted pain to increase subjective task difficulty during cognitive performance. Moreover, according to motivational intensity theory, we expected this to increase effort only when high effort was justified by high monetary incentive. Correspondingly, pain should lead to low effort (disengagement) when monetary incentive was low. Effort in the nonpainful conditions was expected to fall in between these conditions. The results of both studies support our predictions. Our findings provide the first evidence for the moderating effect of monetary incentive on physical pain's impact on effort-related cardiovascular response. Accordingly, motivational incentives can counteract effort deficits associated with pain.

Cognitive exertion affects the appraisal of one's own and other people's pain.

Correctly evaluating others' pain is a crucial prosocial ability. In both clinical and private settings, caregivers assess their other people's pain, sometimes under the effect of poor sleep and high workload and fatigue. However, the effect played by such cognitive strain in the appraisal of others' pain remains unclear. Fifty participants underwent one of two demanding tasks, involving either working memory (Experiment 1: N-Back task) or cognitive interference (Experiment 2: Stroop task). After each task, participants were exposed to painful laser stimulations at three intensity levels (low, medium, high), or video-clips of patients experiencing three intensity levels of pain (low, medium, high). Participants rated the intensity of each pain event on a visual analogue scale. We found that the two tasks influenced rating of both one's own and others' pain, by decreasing the sensitivity to medium and high events. This was observed either when comparing the demanding condition to a control (Stroop), or when modelling linearly the difficulty/performance of each depleting task (N-Back). We provide converging evidence that cognitive exertion affects the subsequent appraisal of one's own and likewise others' pain.

Impact of pain on mental effort assessed as cardiovascular reactivity.

INTRODUCTION: Pain typically impairs task performance, increases fatigue, and is associated with behavioral disengagement. Together, this suggests that pain impacts effort, defined as the mobilization of resources to carry out behavior. However, empirical evidence on this issue is lacking. OBJECTIVES: Drawing on motivational intensity theory, this study investigated the impact of pain on effort mobilization during cognitive task performance. METHODS: We administered individually adjusted painful thermal stimulations during an easy memory task during which we measured effort as cardiovascular reactivity-a valid and objective measure. Control conditions included painful stimulations alone, the memory task alone, and the memory task with nonpainful heat stimulations. We expected pain to increase subjective difficulty due to additional demand on cognitive functioning, and in turn effort according to motivational intensity theory. Effort-related cardiovascular reactivity was predicted to increase along these conditions: pain-alone, task-alone, task with nonpainful stimulations, and the strongest effort when painful stimulations were administered during the task. RESULTS: Overall, the findings offered support to our hypotheses. As predicted, results showed that pain increased subjective task difficulty (P = 0.020). Moreover, most of the effort-related cardiovascular measures showed the expected pattern with the strongest reactivity when painful stimulations were administered during the task compared with the other conditions (p < 0.02). CONCLUSION: These results are first evidence that pain impacts mental effort assessed as cardiovascular reactivity. We discuss how such extra effort might be related to the persistent feeling of fatigue and behavioral disengagement frequently observed in patients with chronic pain.

The implicit "go": masked action cues directly mobilize mental effort.

In this study, we examined the hypothesis that masked general action and inaction cues that are processed during a cognitive task directly mobilize effort exerted during the task. Participants were randomly assigned to an action-prime condition, an inaction-prime condition, or a control condition and performed a Sternberg short-term memory task. The intensity of effort the participants exerted during the task was estimated by measuring their heart responses (cardiac preejection period, PEP) during task performance. As expected, exposure to masked action cues resulted in stronger PEP reactivity than exposure to masked inaction cues. PEP reactivity in the control group fell in between reactivity when action cues were used and reactivity when inaction cues were used. Participants' task performance revealed a corresponding pattern: Reaction times were the shortest in the action-prime condition, increased in the control condition, and increased further in the inaction-prime condition. These results show that masked action cues and inaction cues directly influence the intensity of effort exerted in the performance of a task.

Affect and cognitive control: Insights from research on effort mobilization.

We present theory and research on effort mobilization that is relevant for understanding the role of affect in cognitive control. We posit that cognitive control and effort are closely related and introduce motivational intensity theory and supporting empirical evidence mainly based on cardiovascular measures of effort. Most important, we discuss the role of affect in the context of effort mobilization and cognitive control from different perspectives. We first present theories predicting affective influences on effort, namely the mood-behavior-model and the implicit-affect-primes-effort model, and supporting empirical evidence. Second, we discuss further implications of the resource conservation principle highlighting the aversive aspect of effort and review evidence for the impact of value and its affective component on effort and cognitive control. Finally, we present a recent integration of the neural mechanisms underlying both effort and cognitive control. We conclude that affective processes are necessary and instrumental for both effort mobilization and cognitive control.

On the implicit influence of pain cues on cognitive effort: Evidence from cardiovascular reactivity.

To extend previous findings on the impact of implicit affect on behavior, two experiments investigated the influence of priming pain cues on cognitive effort. Effort was assessed as cardiovascular reactivity (PEP, SBP, DBP, and HR) during an easy or difficult cognitive task integrating briefly presented and masked pain-related words. The control condition included neutral words (Experiment 1) or anger-related words (Experiment 2). The pain primes were expected to increase the perceived difficulty of the task and to result in stronger effort during the easy task, compared to the control condition, and to lower effort during the difficult task, due to disengagement. Overall, cardiovascular reactivity of both experiments supported the predictions. Moreover, pain primes increased self-reported subjective difficulty. Finally, most participants could not report the content of the primes. Findings are discussed regarding the influence of implicit processes in pain experience and regarding the self-regulatory consequences of the influence of pain on effort mobilization.

Psychological and neural mechanisms associated with effort-related cardiovascular reactivity and cognitive control: An integrative approach.

Numerous studies have assessed cardiovascular (CV) reactivity as a measure of effort mobilization during cognitive tasks. However, psychological and neural processes underlying effort-related CV reactivity are still relatively unclear. Previous research reliably found that CV reactivity during cognitive tasks is mainly determined by one region of the brain, the dorsal anterior cingulate cortex (dACC), and that this region is systematically engaged during cognitively demanding tasks. The present integrative approach builds on the research on cognitive control and its brain correlates that shows that dACC function can be related to conflict monitoring and integration of information related to task difficulty and success importance-two key variables in determining effort mobilization. In contrast, evidence also indicates that executive cognitive functioning is processed in more lateral regions of the prefrontal cortex. The resulting model suggests that, when automatic cognitive processes are insufficient to sustain behavior, the dACC determines the amount of required and justified effort according to task difficulty and success importance, which leads to proportional adjustments in CV reactivity and executive cognitive functioning. These propositions are discussed in relation to previous findings on effort-related CV reactivity and cognitive performance, new predictions for future studies, and relevance for other self-regulatory processes.

Task difficulty moderates implicit fear and anger effects on effort-related cardiac response.

Based on the implicit-affect-primes-effort (IAPE) model (Gendolla, 2012, 2015), the present experiment tested whether objective task difficulty moderates the previously found impact of fear and anger primes on effort-related cardiac response during an arithmetic task. We expected that fear primes would lead to stronger cardiac pre-ejection period (PEP) reactivity than anger primes in an easy task, but that anger primes would lead to a stronger PEP response than fear primes in a difficult task. Results corroborated these predictions. Moreover, there was no evidence that the affect primes induced conscious feelings that could explain the observed cardiac reactivity, suggesting that the primes had the intended implicit effect on effort mobilization. The findings contribute to the accumulating evidence in support of the IAPE model, showing that objective task difficulty is a moderator of implicit affect's influence on effort-related cardiac response.

Automatic effort mobilization and the principle of resource conservation: one can only prime the possible and justified.

Two experiments tested the idea that the principle of resource conservation moderates and limits automaticity effects on effort mobilization. Effort-related cardiovascular response was assessed in cognitive tasks with different levels of task difficulty (Experiment 1) and success incentive (Experiment 2) during which participants were exposed to suboptimally presented action versus inaction primes. As expected, implicit activation of the action concept resulted in stronger effort-related cardiovascular response than activation of the inaction concept-but only when the task was feasible and success incentive was sufficiently high. Effects on task performance were compatible with those on effort. The findings indicate that the automaticity effect of action/inaction primes on effort mobilization is situated, sensitive to task context, and limited by extreme task difficulty and low incentive. The findings facilitate a theoretical integration of automaticity in effort mobilization with the principle of resource conservation.

Beyond valence: the differential effect of masked anger and sadness stimuli on effort-related cardiac response.

This experiment investigated the moderating effect of masked anger versus sadness primes on objective task difficulty's impact on effort-related cardiovascular response. Cardiovascular measures (ICG and blood pressure) were assessed during a habituation period and an easy versus difficult short-term memory task during which participants were exposed to masked emotional facial expressions. As expected, sadness primes led to stronger cardiac preejection period (PEP) responses than anger primes when the task was easy. When the task was difficult, we observed the reversed pattern. Here, anger primes led to stronger PEP reactivity than sadness primes. Heart rate responses described the corresponding pattern. The results demonstrate that masked anger and sadness primes have different effects on cardiac response in easy and difficult tasks. The effect of anger primes resembles the facilitating effect of happiness primes observed in previous studies.

ß-adrenergic impact underlies the effect of mood and hedonic instrumentality on effort-related cardiovascular response.

After habituation, participants were first induced into negative vs. positive moods and performed then an attention task with either low vs. high hedonic instrumentality of success. In the high-instrumentality condition participants expected to see a funny movie after success and an unpleasant movie after failure; in the low-instrumentality condition participants expected an unpleasant movie after success and a pleasant movie after failure. Effort-related cardiovascular response (ICG, blood pressure) was assessed during mood inductions and task performance. As predicted by the mood-behavior-model (Gendolla, 2000), responses of cardiac pre-ejection period (PEP) and systolic blood pressure were stronger in the high-instrumentality/negative-mood condition than in the other three cells. Here the high hedonic instrumentality of success justified the high effort that was perceived as necessary in a negative mood. Moreover, the PEP effects indicate that cardiovascular response was driven by beta-adrenergic impact on the heart rather than by vascular adjustments.

Masked affective stimuli moderate task difficulty effects on effort-related cardiovascular response.

This experiment investigated the combined effect of masked affective stimuli and task difficulty on effort-related cardiovascular response. Cardiovascular reactivity (ICG, blood pressure) was recorded during a baseline period and performance of an easy or difficult attention task in which participants were exposed to masked sad vs. happy facial expressions. As expected, participants in the sad-faces/easy and happy-faces/difficult conditions showed stronger sympathetic nervous system discharge to the heart and vasculature--shorter preejection period, higher systolic blood pressure--indicating more effort than participants in the sad-faces/difficult and happy-faces/easy conditions. Total peripheral resistance reacted similarly as preejection period and systolic blood pressure. The findings are compatible with the effects of consciously experienced affect on effort-related cardiovascular response.

Do not prime too much: Prime frequency effects of masked affective stimuli on effort-related cardiovascular response.

This experiment investigated the prime frequency effect of masked affective stimuli on effort-related cardiovascular response. Cardiovascular reactivity was recorded during a baseline period and an attention task in which either 1/3, 2/3, or 3/3 of the trials included the presentation of masked emotional facial expressions (sad vs. happy). In the resting trials participants were exposed to masked neutral expressions. As expected, and replicating previous findings (Gendolla and Silvestrini, in press), participants in the 1/3 priming condition showed stronger systolic blood pressure reactivity--indicating more effort--when they were exposed to masked sad faces than when they were exposed to masked happy faces. This effect disappeared in the 2/3 and 3/3 conditions. Findings are interpreted as demonstrating habituation effects of masked affective stimuli on effort mobilization.

Smiles make it easier and so do frowns: masked affective stimuli influence mental effort.

Two experiments tested the hypothesis that exposure to masked emotional expressions during the performance of cognitive tasks influences effort mobilization. In support of the predictions, participants who processed masked sad faces during task performance under "do your best" instructions showed stronger sympathetic nervous system discharge to the heart (shorter pre-ejection period, higher systolic blood pressure) than participants who were exposed to masked smiling faces or angry faces. Assessed task appraisals suggest that these effects on effort-related cardiovascular reactivity occurred because the masked emotional stimuli influenced the level of experienced task difficulty. The findings are compatible with the effects of consciously experienced affect on effort-related cardiovascular response.