RESUMEN
Fibroblastic reticular cells (FRCs) form a cellular network that serves as the structural backbone of lymph nodes and facilitates lymphocyte migration. In mice, this FRC network has been found to have small-world properties. Using a model based on geographical preferential attachment, we simulated the formation of a variety of cellular networks and show that similar small-world properties robustly emerge under such natural conditions. By estimating the parameters of this model, we generated FRC network representations with realistic topological properties. We found that the topological properties change markedly when the network is expanded from a thin slice to a three-dimensional cube. Typical small-world properties were found to persist as network size was increased. The simulated networks were very similar to two-dimensional and three-dimensional lattice networks. According to the used metrics, these lattice networks also have small-world properties, indicating that lattice likeness is sufficient to become classified as a small-world network. Our results explain why FRC networks have small-world properties and provide a framework for simulating realistic FRC networks.