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Transplantation ; 85(1): 9-14, 2008 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-18192905

RESUMEN

BACKGROUND: There are unresolved issues regarding the security of liver transplantation with non-heart-beating donors (NHBDs). Recently, an increased incidence of biliary complications, mainly intrahepatic ischemic-type biliary strictures, has been described after controlled NHBDs. METHODS: We studied the incidence and risk factors for biliary complications among uncontrolled NHBDs recipients compared with a large population of HBD recipients. RESULTS: Overall, 16.8% of patients in the HBD group and 41.7% of patients in the NHBD group suffered any type of biliary complication (P=0.66). However, the incidence of nonanastomotic biliary strictures was significantly greater in the NHBD group (P<0.001). Multivariate analysis showed that independent risk factors for nonanastomotic strictures were hepatic artery thrombosis (relative risk; 98.7) and receiving a liver from a NHBD (relative risk; 47.1). CONCLUSIONS: If this type of donors is accepted as a source of liver organs, the high incidence of biliary complications should be considered and efforts should be made to decrease ischemic injury.


Asunto(s)
Colestasis Intrahepática/etiología , Paro Cardíaco , Trasplante de Hígado/efectos adversos , Donantes de Tejidos , Obtención de Tejidos y Órganos/clasificación , Adulto , Anciano , Supervivencia de Injerto , Humanos , Incidencia , Persona de Mediana Edad , Análisis Multivariante , Estudios Retrospectivos , Factores de Riesgo
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