RESUMEN
Obesity is a global health concern with numerous comorbidities, including cardiovascular diseases, type 2 diabetes, and certain cancers. Carotenoids, found in a variety of natural sources like fruits and vegetables, are known for their potential health benefits. Emerging research suggests that certain carotenoids may play a major role in combating obesity through mechanisms involving inflammation, oxidative stress, and lipid metabolism. Understanding the influence of carotenoids on metabolic health could offer valuable revelation about obesity management strategies. To summarize the main findings on carotenoids that help in the management and prevention of obesity, exploring their potential benefits in weight management, metabolic health, and overall well-being. An extensive literature survey was done on the management of obesity using PubMed, Elsevier, ScienceDirect, and Springer. The results were then filtered based on the titles, abstracts, and accessibility of the complete texts. The search engine Google Scholar was accessed for the literature data mining. This review highlights the diverse functions of carotenoids, such as their antioxidant properties, anti-inflammatory effects, and regulation of lipid metabolism, which contribute to their potential role in combating obesity. Studies suggest that carotenoids may help reduce adiposity, lipid accumulation, improve insulin sensitivity, and promote overall metabolic health, making them promising candidates for obesity management. Obesity is synonymous with the appearance of major diseases and an overall decline in physical and mental performance. Overall, the findings of this review endorse the possible application of carotenoids as a nutritional supplement for the management and prevention of obesity. Further research is needed to clarify the mechanisms underlying the beneficial impacts of carotenoids on obesity-related consequences and to optimize their utilization in clinical practice and public health campaigns.
RESUMEN
BACKGROUND: Type 2 diabetes mellitus (T2DM) is frequently referred to as a "lifestyle illness". In 2000, India (31.7 million) had the greatest global prevalence of diabetes mellitus, followed by China (20.8 million), the United States (17.7 million), and other countries. In recent years, the treatment of gene therapy (T2DM) has attracted intensive interest. OBJECTIVE: We aimed to critically review the literature on the various techniques and methods, which may be a possible novel approach through the gene therapy CRISPR Cas9 and some other gene editing techniques for T2DM. Interventional and pharmacological approaches for the treatment of T2DM were also included to identify novel therapies for its treatment. METHOD: An extensive literature survey was done on databases like PubMed, Elsevier, Science Direct and Springer. CONCLUSION: It can be concluded from the study that recent advancements in gene-editing technologies, such as CRISPR Cas9, have opened new avenues for the development of novel therapeutic approaches for T2DM. CRISPR Cas9 is a powerful tool that enables precise and targeted modifications of the genome.
RESUMEN
OBJECTIVES: To evaluate and compare the shear bond strength of stainless-steel brackets using three different light curing units. MATERIAL AND METHODS: Using three LED curing units (3M ESPE Elipar, Ivoclar bluephase, and Woodpecker I LED light cure), 120 precoated metal brackets (Gemini series, 3M Unitek) were cured. The shear bond strength was recorded using a universal testing machine. RESULT: The shear strength of the bracket in different light-curing systems was examined with ANOVA test. The mean shear strength of group A, group B, and group C were 16.03 ± 14.30 MPA, 16.86 ± 11.89 MPA, and 20.51 ± 19.40, respectively. The result of the analysis shows that there is a major difference in shear bond strength of these three different light-curing systems with F value = 3.94 and P value 0.04. CONCLUSION: We used three LED light-curing units with different intensities and manufacturing companies. The result showed that woodpecker I LED light had significantly highest mean SBS than the other two (Elipar LED curing light and 3M ESPE, Ivoclar bluephase).
RESUMEN
Superficial fungal infection in immunocompromised patients can lead to many disorders and complications. Currently, new topical treatment options are critically needed to treat these fungal infections. Luliconazole (LZL) is a topical antifungal medicine used for fungal infection treatment. The purpose of this paper was to develop a new topical luliconazole nanocrystal (LNC) incorporated hydrogel. This study suggested the potential benefits of LNC embedded in a gel as a drug delivery system for topical antifungal treatments. Preliminary experiments were therefore carried out to characterize the LNC in comparison with raw drug. Prepared gel was homogeneous for human use with about 88 percent trapping, non-irritant and safe. Nano-systems showed an overall 5 fold enhancement in solubility, 4 fold increase in dissolution velocity, higher skin retention and better antifungal activity. Drugs retained from LNC hydrogel (N-GEL) in different skin layers within 8 h were the highest, i.e. 62.17% compared to coarse suspension (41.87%), nanosuspension (49.77%), D-GEL (55.76%). In addition, LNC and N-GEL had higher ZOI (41.20 ± 0.61mm and 44.25 ± 0.57mm respectively) than LZL and D-GEL (35.98 ± 0.81mm and 36.83 ± 0.83mm respectively). Therefore, it was observed that LNC loaded hydrogel was more effective in killing the fungus. Consequently, hydrogel incorporated with LNC could be a new approach with improved activity and increased dermal delivery for drugs with poor aqueous solubility rather than coarse drug containing gel.