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1.
Bull Math Biol ; 79(12): 2814-2846, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29098537

RESUMEN

Tear film thinning, hyperosmolarity, and breakup can cause irritation and damage to the human eye, and these form an area of active investigation for dry eye syndrome research. Recent research demonstrates that deficiencies in the lipid layer may cause locally increased evaporation, inducing conditions for breakup. In this paper, we explore the conditions for tear film breakup by considering a model for tear film dynamics with two mobile fluid layers, the aqueous and lipid layers. In addition, we include the effects of osmosis, evaporation as modified by the lipid, and the polar portion of the lipid layer. We solve the system numerically for reasonable parameter values and initial conditions and analyze how shifts in these cause changes to the system's dynamics.


Asunto(s)
Modelos Biológicos , Lágrimas/metabolismo , Simulación por Computador , Síndromes de Ojo Seco/etiología , Síndromes de Ojo Seco/metabolismo , Glicocálix/metabolismo , Humanos , Metabolismo de los Lípidos , Conceptos Matemáticos , Distribución Normal , Concentración Osmolar , Tensoactivos/metabolismo , Agua/metabolismo
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