RESUMEN
Local health departments are organized, resourced, and operated primarily for routine public health services. For them, responding to emergencies and disasters requires adaptation to meet the demands of an emergency, and they must reallocate or augment resources, adjust work schedules, and, depending on severity and duration of the event, even compromise routine service outputs. These adaptations occur to varying degrees regardless of the type of emergency or disaster. The Adaptive Response Metric was developed through collaboration between a number of California health departments and university-based preparedness researchers. It measures the degree of "stress" from an emergency response as experienced by local health departments at the level of functional units (eg, nursing, administration, environmental services). Pilot testing of the Adaptive Response Metric indicates its utility for emergency planning, real-time decision making, and after-action analytics.
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Servicios de Salud Comunitaria/organización & administración , Técnicas de Apoyo para la Decisión , Planificación en Desastres/métodos , California , Humanos , Subtipo H1N1 del Virus de la Influenza A , Gripe Humana , Pandemias , Proyectos PilotoRESUMEN
OBJECTIVE: Since states' public health systems differ as to pandemic preparedness, this study explored whether such heterogeneity among states could affect the nation's overall influenza rate. DESIGN: The Centers for Disease Control and Prevention produced a uniform set of scores on a 100-point scale from its 2008 national evaluation of state preparedness to distribute materiel from the Strategic National Stockpile (SNS). This study used these SNS scores to represent each state's relative preparedness to distribute influenza vaccine in a timely manner and assumed that "optimal" vaccine distribution would reach at least 35% of the state's population within 4 weeks. The scores were used to determine the timing of vaccine distribution for each state: each 10-point decrement of score below 90 added an additional delay increment to the distribution time. SETTING AND PARTICIPANTS: A large-scale agent-based computational model simulated an influenza pandemic in the US population. In this synthetic population each individual or agent had an assigned household, age, workplace or school destination, daily commute, and domestic intercity air travel patterns. MAIN OUTCOME MEASURES: Simulations compared influenza case rates both nationally and at the state level under 3 scenarios: no vaccine distribution (baseline), optimal vaccine distribution in all states, and vaccine distribution time modified according to state-specific SNS score. RESULTS: Between optimal and SNS-modified scenarios, attack rates rose not only in low-scoring states but also in high-scoring states, demonstrating an interstate spread of infections. Influenza rates were sensitive to variation of the SNS-modified scenario (delay increments of 1 day versus 5 days), but the interstate effect remained. CONCLUSIONS: The effectiveness of a response activity such as vaccine distribution could benefit from national standards and preparedness funding allocated in part to minimize interstate disparities.
Asunto(s)
Defensa Civil , Vacunas contra la Influenza/provisión & distribución , Gripe Humana/prevención & control , Pandemias , Simulación por Computador , Humanos , Gripe Humana/epidemiología , Gobierno Estatal , Estados Unidos/epidemiologíaRESUMEN
OBJECTIVES: The Pittsburgh Influenza Prevention Project (PIPP) has previously shown that school-aged children in grades K-5 can learn hygiene-based, nonpharmaceutical interventions (NPIs) and persist in these behaviors over the duration of an influenza season. The purpose of this study was to determine whether age (as estimated by grade) plays any role in this ability. METHODS: The Pittsburgh Influenza Prevention Project is a prospective, controlled, randomized trial of the effectiveness of a suite of NPIs in 10 elementary schools. The project measured adoption of NPIs by students through surveys of intervention homeroom teachers before, during, and after the influenza season and control home-room teachers after influenza season. RESULTS: There were large, statistically significant improvements and persistence over time across all grade levels, in students' concern about influenza and their daily practice of NPIs that promote health behaviors-"wash or sanitize your hands often" and "cover your coughs and sneezes." Nonpharmaceutical interventions characterized as extinguishing unhealthy behaviors, such as "avoid touching your eyes, nose, and mouth" or "home is where you stay when you are sick," showed no reliable improvement. CONCLUSIONS: The study provides evidence that elementary school-aged children, across all grades, can understand and implement protective NPIs and maintain these activities throughout influenza season and beyond. Improvements were most prominent when teaching students to engage in health-promoting behaviors. Habitual behaviors (unconscious touching) and changing family behaviors (staying home) seem less susceptible to intervention. These results will be useful to public health policy makers and health care practitioners considering methods of infectious disease prevention in school-based settings.
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Factores de Edad , Conocimientos, Actitudes y Práctica en Salud , Higiene/educación , Gripe Humana/prevención & control , Instituciones Académicas , Estudiantes/clasificación , Adulto , Niño , Docentes/estadística & datos numéricos , Femenino , Humanos , Masculino , Variaciones Dependientes del Observador , Pennsylvania , Proyectos Piloto , Estaciones del Año , Estudiantes/psicología , Encuestas y Cuestionarios , Población UrbanaRESUMEN
Laws and regulations can facilitate or impede emergency preparedness and response activities. State legislators, judges, and lawyers play critically important roles in creating and interpreting laws that affect the ability of public health practitioners and their partners to effectively respond to emergencies. In an age when political unrest, global travel, and emerging biological threats can combine to create social and economic havoc worldwide, it is critical that those responsible for upholding the rule of law during emergencies understand the law and its implications. In 2003, the University of Pittsburgh Center for Public Health Preparedness (UP-CPHP) created a Preparedness Law and Policy Program to advance legal preparedness for public health emergencies across Pennsylvania and the nation. To achieve this goal, UP-CPHP has partnered with local, state, and national organizations. In the course of these activities, Pennsylvania judges, the Administrative Office of Pennsylvania Courts, UP-CPHP, and the Centers for Disease Control and Prevention's Public Health Law Program have developed a strong and enduring collaborative relationship that has put the Pennsylvania judiciary in a better position today to plan for and respond to a public health crisis than it has been at any other point in its history. The tools and resources developed through this collaboration can readily be adapted to assist other jurisdictions nationwide in their efforts to ensure that their judicial systems are similarly prepared.
Asunto(s)
Conducta Cooperativa , Planificación en Desastres/normas , Administración en Salud Pública/legislación & jurisprudencia , Gobierno Estatal , Centers for Disease Control and Prevention, U.S. , Humanos , Estudios de Casos Organizacionales , Pennsylvania , Estados UnidosRESUMEN
BACKGROUND: Public health departments often miss the opportunity to both learn from outbreaks and disasters and share any 'lessons learned' with other public health partners. These missed opportunities inhibit the public health system's ability to improve, change and adapt in an organized way. METHODS: In 2003, Western Pennsylvania experienced the largest documented hepatitis A outbreak in US history. The authors documented the key facets of both the outbreak and the response, and in the process developed improved methods for capturing the historical record in an efficient and comprehensive fashion. This process incorporates key aspects of oral history, along with typical public health parameters such as epidemic curves and environmental risk factors, and allows for creation of unique tools for documentation and sharing with diverse audiences. CONCLUSIONS: Learning from experience is an essential part of reducing mistakes, improving public health response, and the methods described herein show one way that 'lessons learned' can become a valuable teaching/training tool for students and practitioners.
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Brotes de Enfermedades/prevención & control , Virus de la Hepatitis A/aislamiento & purificación , Hepatitis A/epidemiología , Hepatitis A/prevención & control , Práctica de Salud Pública , Planificación en Desastres/organización & administración , Humanos , Pennsylvania/epidemiologíaRESUMEN
OBJECTIVES: The purpose of this study was to determine to what extent school-aged children can learn hygiene-based nonpharmaceutical interventions (NPIs) and persist in these behavioral changes over the duration of an influenza season. If this can be done successfully, it may be a preferable pandemic mitigation strategy to much more disruptive strategies such as whole-scale school closure. METHODS: The Pittsburgh Influenza Prevention Project (PIPP) is a prospective, controlled, randomized trial of the effectiveness of a suite of hygiene-based NPIs in controlling influenza and related illnesses in elementary schools in the City of Pittsburgh. During the 2007-08 school year, the project measured adoption of NPIs by students in five elementary schools through surveys of home-room teachers before, during, and after influenza season. RESULTS: Results showed highly statistically significant improvement in students' daily practice of nearly all of the NPIs, including hand washing and sanitizer use and covering coughs and sneezes. CONCLUSIONS: The study provides evidence that children can learn, implement, and persist in the behaviors of a multilayered suite of NPIs over a typical flu season. These results will be useful to public health policy makers and practitioners considering methods of infectious disease prevention in school-based settings.
Asunto(s)
Conocimientos, Actitudes y Práctica en Salud , Higiene , Gripe Humana/prevención & control , Instituciones Académicas , Desinfección de las Manos , Conductas Relacionadas con la Salud , Humanos , Gripe Humana/transmisión , Pennsylvania , Estudios ProspectivosRESUMEN
BACKGROUND: There remains substantial debate over the impact of school closure as a mitigation strategy during an influenza pandemic. The ongoing 2009 H1N1 influenza pandemic has provided an unparalleled opportunity to test interventions with the most up-to-date simulations. METHODS: To assist the Allegheny County Health Department during the 2009 H1N1 influenza pandemic, the University of Pittsburgh Models of Infectious Disease Agents Study group employed an agent-based computer simulation model (ABM) of Allegheny County, Pennsylvania, to explore the effects of various school closure strategies on mitigating influenza epidemics of different reproductive rates (R0). RESULTS: Entire school system closures were not more effective than individual school closures. Any type of school closure may need to be maintained throughout most of the epidemic (ie, at least 8 weeks) to have any significant effect on the overall serologic attack rate. In fact, relatively short school closures (ie, 2 weeks or less) may actually slightly increase the overall attack rate by returning susceptible students back into schools in the middle of the epidemic. Varying the illness threshold at which school closures are triggered did not seem to have substantial impact on the effectiveness of school closures, suggesting that short delays in closing schools should not cause concern. CONCLUSIONS: School closures alone may not be able to quell an epidemic but, when maintained for at least 8 weeks, could delay the epidemic peak for up to a week, providing additional time to implement a second more effective intervention such as vaccination.
Asunto(s)
Simulación por Computador , Subtipo H1N1 del Virus de la Influenza A , Gripe Humana/prevención & control , Prevención Primaria/métodos , Cuarentena/métodos , Instituciones Académicas , Adulto , Calibración/normas , Niño , Brotes de Enfermedades/prevención & control , Eficiencia Organizacional , Exposición a Riesgos Ambientales/estadística & datos numéricos , Humanos , Subtipo H1N1 del Virus de la Influenza A/patogenicidad , Gripe Humana/epidemiología , Gripe Humana/transmisión , Modelos Estadísticos , Pennsylvania/epidemiología , Cuarentena/estadística & datos numéricos , Características de la Residencia/clasificación , Instituciones Académicas/estadística & datos numéricos , Viaje/estadística & datos numéricosRESUMEN
The QuickVue Influenza A+B Test (Quidel) was used to test nasal swab specimens obtained from persons with influenza-like illness in 3 different populations. Compared with reverse-transcriptase polymerase chain reaction, the test sensitivity was low for all populations (median, 27%; range, 19%-32%), whereas the specificity was high (median, 97%; range, 96%-99.6%).
Asunto(s)
Inmunoensayo/métodos , Gripe Humana/diagnóstico , Adolescente , Adulto , Anciano , Niño , Preescolar , Humanos , Lactante , Virus de la Influenza A/aislamiento & purificación , Virus de la Influenza B/aislamiento & purificación , Persona de Mediana Edad , Mucosa Nasal/virología , Juego de Reactivos para Diagnóstico , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Sensibilidad y Especificidad , Adulto JovenRESUMEN
OBJECTIVES: Schools act as "amplifying sites" for the spread of infectious diseases, outbreaks, and pandemics. This project assessed which nonpharmaceutical interventions (NPIs) are most acceptable to parents and teachers of school children in grades K-5 to K-8 in Pittsburgh public schools. METHODS: During the spring of 2007, the Pittsburgh Influenza Prevention Project surveyed 134 teachers and 151 parents representing nine elementary schools regarding attitudes toward NPIs and their usage by adults and school children during seasonal influenza outbreaks. RESULTS: General etiquette practices such as covering coughs, handwashing, and using hand sanitizer were highly acceptable to both groups, while masks and gloves were not. CONCLUSIONS: The success of an NPI or a set of NPIs depends on both its efficacy and the feasibility of implementing it with relevant populations. If masks, gloves, and other more intrusive NPIs are to be used in community settings during a severe influenza season or pandemic, it is clear that there is significant preparatory work needed to increase acceptability on the part of the adults. Without such acceptance, it is highly unlikely that children and their supervising adults will participate.
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Conocimientos, Actitudes y Práctica en Salud , Control de Infecciones/métodos , Gripe Humana/prevención & control , Gripe Humana/transmisión , Servicios de Salud Escolar , Niño , Brotes de Enfermedades/prevención & control , Docentes , Humanos , Gripe Humana/epidemiología , Pennsylvania/epidemiología , Proyectos PilotoRESUMEN
The effect of school-based non-pharmaceutical interventions (NPIs) on influenza A and B transmission in children's households has not been estimated in published literature. We use data from a large school-based cluster randomized trial of improved hand and respiratory hygiene measures to explore the secondary transmission of influenza A and B in households of laboratory confirmed influenza cases. Data were taken from the Pittsburgh Influenza Prevention Project, a cluster-randomized trial of NPIs conducted in ten Pittsburgh, PA elementary schools during the 2007-2008 influenza season. We estimated two measures of influenza transmissibility in households; the susceptible infectious transmission probability, using variants of the Reed-Frost chain binomial model, and the secondary attack rate. We identified predictors of ILI using a logistic generalized estimating equation model. We estimate the secondary attack rates in intervention households to be 0.26 (95% confidence interval (CI) 0.19-0.34) compared to 0.30 (95% CI 0.23-0.38) in control households. Race and age were significant risk factors for secondary ILI acquisition in this study. We found no significant differences between the transmission probabilities for infectious individuals in intervention (0.19, 95% CI 0.14-0.25), and control households (0.22, 95% CI 0.16-0.29). Similarly, estimates for secondary attack rates and transmission probabilities for households with confirmed influenza A (0.31 and 0.22) were not significantly different from estimates from households with confirmed influenza B (0.25 and 0.20). While influenza A and B are thought to have different transmission characteristics, we find no significant differences in their transmissibility within households. Though our results suggest a potential effect, we found no statistically significant effect of school-based non-pharmaceutical interventions on transmission in symptomatic children's homes.
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Composición Familiar , Desinfección de las Manos , Virus de la Influenza A , Virus de la Influenza B , Gripe Humana/prevención & control , Gripe Humana/transmisión , Máscaras , Estudiantes/estadística & datos numéricos , Estudios de Casos y Controles , Niño , Femenino , Desinfección de las Manos/métodos , Humanos , Virus de la Influenza A/aislamiento & purificación , Virus de la Influenza B/aislamiento & purificación , Gripe Humana/epidemiología , Gripe Humana/virología , Masculino , Máscaras/estadística & datos numéricos , Cómputos Matemáticos , Pennsylvania/epidemiología , Proyectos de Investigación , Factores de Riesgo , Instituciones Académicas , Estaciones del AñoRESUMEN
BACKGROUND: Influenza is a contagious respiratory disease responsible for annual seasonal epidemics in temperate climates. An understanding of how influenza spreads geographically and temporally within regions could result in improved public health prevention programs. The purpose of this study was to summarize the spatial and temporal spread of influenza using data obtained from the Pennsylvania Department of Health's influenza surveillance system. METHODOLOGY AND FINDINGS: We evaluated the spatial and temporal patterns of laboratory-confirmed influenza cases in Pennsylvania, United States from six influenza seasons (2003-2009). Using a test of spatial autocorrelation, local clusters of elevated risk were identified in the South Central region of the state. Multivariable logistic regression indicated that lower monthly precipitation levels during the influenza season (ORâ=â0.52, 95% CI: 0.28, 0.94), fewer residents over age 64 (ORâ=â0.27, 95% CI: 0.10, 0.73) and fewer residents with more than a high school education (ORâ=â0.76, 95% CI: 0.61, 0.95) were significantly associated with membership in this cluster. In addition, time series analysis revealed a temporal lag in the peak timing of the influenza B epidemic compared to the influenza A epidemic. CONCLUSIONS: These findings illustrate a distinct spatial cluster of cases in the South Central region of Pennsylvania. Further examination of the regional transmission dynamics within these clusters may be useful in planning public health influenza prevention programs.
Asunto(s)
Gripe Humana/epidemiología , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Análisis por Conglomerados , Femenino , Humanos , Lactante , Gripe Humana/transmisión , Modelos Logísticos , Masculino , Persona de Mediana Edad , Oportunidad Relativa , Pennsylvania/epidemiología , Lluvia , Estaciones del Año , Factores Socioeconómicos , Factores de Tiempo , Adulto JovenRESUMEN
BACKGROUND: Understanding the mechanism of influenza spread across multiple geographic scales is not complete. While the mechanism of dissemination across regions and states of the United States has been described, understanding the determinants of dissemination between counties has not been elucidated. The paucity of high resolution spatial-temporal influenza incidence data to evaluate disease structure is often not available. METHODOLOGY AND FINDINGS: We report on the underlying relationship between the spread of influenza and human movement between counties of one state. Significant synchrony in the timing of epidemics exists across the entire state and decay with distance (regional correlation=62%). Synchrony as a function of population size display evidence of hierarchical spread with more synchronized epidemics occurring among the most populated counties. A gravity model describing movement between two populations is a stronger predictor of influenza spread than adult movement to and from workplaces suggesting that non-routine and leisure travel drive local epidemics. CONCLUSIONS: These findings highlight the complex nature of influenza spread across multiple geographic scales.
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Gripe Humana/epidemiología , Brotes de Enfermedades , Humanos , Densidad de PoblaciónRESUMEN
Local public health agencies often must respond to health-related emergencies or disasters, while continuing to fulfill all public health functions for which they are funded. This article reports the development and initial pilot test of a method for measuring the nature and degree of a public health agency's response to such an emergency or disaster. How the instrument was developed as well as the initial results from the pilot study of four local public health systems (LPHSs) are presented and discussed. The instrument measured the extent to which each function and division of each of the four LPHSs were affected and provided a metric that could be used across LPHSs to indicate the burden experienced by each due to the emergency. Results obtained from the pilot study indicate that size and complexity of an LPHS was not predictive of its ability to respond to the emergency. These results support the use of the framework and associated measurement procedures to provide valuable information to managers responsible for such LPHSs. Such information should provide a foundation for comparing variations in performance and outcomes to various types of emergencies that vary in their severity and focus.
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Planificación en Desastres/organización & administración , Evaluación de Programas y Proyectos de Salud/métodos , Práctica de Salud Pública , Planificación en Desastres/normas , Humanos , Gobierno Local , Proyectos Piloto , Evaluación de Programas y Proyectos de Salud/normas , Reproducibilidad de los ResultadosRESUMEN
Calls for more public health education for medical students date back at least 150 years. In recent years, medical schools have increased their required coursework in core public health topics such as epidemiology, biostatistics, and behavioral determinants of health. Some schools have created more in-depth alternatives, including combined or concurrent master's degrees; MD/PhD programs with a public health track; certificates in public health; or complete re-envisioning of the school into an integrated medical and public health institution. In 2009 the University of Pittsburgh School of Medicine began a Public Health Area of Concentration (AOC) that provides an optional, integrated curriculum that includes key elements of research, practice, and leadership. The AOC is a partnership between two schools at the University of Pittsburgh--Medicine and Public Health--and the local county health department. The result is a program that provides mentorship and training over 4 years of education designed to mend the long historical divide between the skills and constituencies of individual and population health. In addition, the AOC is relatively easy and inexpensive to implement and is modular in nature. The Public Health AOC is a simple model for incorporating many key aspects of public health into medical education and can be duplicated by any university that is willing to create partnerships and work across boundaries.
Asunto(s)
Educación Médica/organización & administración , Modelos Educacionales , Salud Pública/educación , Facultades de Medicina/organización & administración , Certificación , Conducta Cooperativa , Curriculum , Humanos , Mentores , Práctica de Salud Pública , Escuelas de Salud Pública/organización & administración , Estudiantes de MedicinaRESUMEN
INTRODUCTION: Rapid influenza testing (RFT) allows for a rapid point-of-care diagnosis of influenza. The Quidel QuickVue Influenza A+B test (QuickVue) has a reported manufacturer's sensitivity and specificity of 73% and 96%, respectively, with nasal swabs. However, investigators have shown sensitivities ranging from 22% to 77% in community settings. METHODS: The QuickVue rapid influenza test was evaluated in a population of elementary (K-5) school children, using testing in the home, as part of the Pittsburgh Influenza Prevention Project during the 2007-2008 influenza season. The QuickVue test was performed with nasal swab in full accordance with package instructions and compared with the results of nasal swab semi-quantitative RT-PCR. RESULTS: Sensitivity of the QuickVue was found to be 27% in this sample. There was no statistically valid correlation between the semi-quantitative PCR result and the QuickVue result. CONCLUSIONS: This study is consistent with the low sensitivity of the QuickVue test also reported by others. Viral load, technique, and the use of nasal swabs were examined as contributing factors but were not found to be explanations for this result. Community testing includes patients who are on the lower spectrum of illness which would not be the case in hospital or clinic samples. This suggests that RFT is less sensitive for patients at the lower spectrum of illness, with less severe disease.
Asunto(s)
Gripe Humana/diagnóstico , Niño , Humanos , Mucosa Nasal/virología , Sistemas de Atención de Punto , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Sensibilidad y EspecificidadRESUMEN
BACKGROUND: Laboratory-based evidence is lacking regarding the efficacy of nonpharmaceutical interventions (NPIs) such as alcohol-based hand sanitizer and respiratory hygiene to reduce the spread of influenza. METHODS: The Pittsburgh Influenza Prevention Project was a cluster-randomized trial conducted in 10 elementary schools in Pittsburgh, PA, during the 2007 to 2008 influenza season. Children in 5 intervention schools received training in hand and respiratory hygiene, and were provided and encouraged to use hand sanitizer regularly. Children in 5 schools acted as controls. Children with influenza-like illness were tested for influenza A and B by reverse-transcriptase polymerase chain reaction. RESULTS: A total of 3360 children participated in this study. Using reverse-transcriptase polymerase chain reaction, 54 cases of influenza A and 50 cases of influenza B were detected. We found no significant effect of the intervention on the primary study outcome of all laboratory-confirmed influenza cases (incidence rate ratio [IRR]: 0.81; 95% confidence interval [CI]: 0.54, 1.23). However, we did find statistically significant differences in protocol-specified ancillary outcomes. Children in intervention schools had significantly fewer laboratory-confirmed influenza A infections than children in control schools, with an adjusted IRR of 0.48 (95% CI: 0.26, 0.87). Total absent episodes were also significantly lower among the intervention group than among the control group; adjusted IRR 0.74 (95% CI: 0.56, 0.97). CONCLUSIONS: NPIs (respiratory hygiene education and the regular use of hand sanitizer) did not reduce total laboratory-confirmed influenza. However, the interventions did reduce school total absence episodes by 26% and laboratory-confirmed influenza A infections by 52%. Our results suggest that NPIs can be an important adjunct to influenza vaccination programs to reduce the number of influenza A infections among children.
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Desinfección de las Manos , Virus de la Influenza A/inmunología , Virus de la Influenza B/inmunología , Gripe Humana/prevención & control , Absentismo , Adolescente , Estudios de Casos y Controles , Niño , Preescolar , Tos/prevención & control , Femenino , Humanos , Higiene/educación , Incidencia , Gripe Humana/epidemiología , Gripe Humana/inmunología , Gripe Humana/virología , ARN Viral/análisis , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Instituciones Académicas , Estudiantes , Estados UnidosRESUMEN
In June 2006, the Centers for Disease Control and Prevention released a request for applications to identify, improve, and evaluate the effectiveness of nonpharmaceutical interventions (NPIs)-strategies other than vaccines and antiviral medications-to mitigate the spread of pandemic influenza within communities and across international borders (RFA-CI06-010). These studies have provided major contributions to seasonal and pandemic influenza knowledge. Nonetheless, key concerns were identified related to the acceptability and protective efficacy of NPIs. Large-scale intervention studies conducted over multiple influenza epidemics, as well as smaller studies in controlled laboratory settings, are needed to address the gaps in the research on transmission and mitigation of influenza in the community setting. The current novel influenza A (H1N1) pandemic underscores the importance of influenza research.
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Brotes de Enfermedades/prevención & control , Transmisión de Enfermedad Infecciosa/prevención & control , Gripe Humana/epidemiología , Gripe Humana/prevención & control , Humanos , Gripe Humana/transmisiónRESUMEN
Rotavirus infection is a ubiquitous illness, infecting the vast majority of children worldwide in the first 5 years of life. Rotavirus is one of the major causes of severe diarrhea in infants and young children throughout the developing and developed world. An estimated 500,000 deaths per year occur, with the burden of morbidity and mortality highest in the poorest nations. Two new oral, live, attenuated vaccines have recently shown efficacy and safety in clinical trials, and one of these, RotaTeq, was approved by the US Food and Drug Administration on February 3, 2006. RotaTeq is recommended for general use by the Centers for Disease Control and Prevention, American Academy of Family Practice, and American Academy of Pediatrics.